Effects of acupuncture at the points of the Pericardium Meridian on the activity of myocardial Ca~(2+)-ATPase and gene expression in the rat of myocardial ischemia and reperfusion injury

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Effects of acupuncture at the points of the Pericardium Meridian on the activity of myocardial Ca~(2+)-ATPase and gene expression in the rat of myocardial ischemia and reperfusion injury

更新时间：2023-05-10

- Effects of acupuncture at the points of the Pericardium Meridian on the activity of myocardial Ca~(2+)-ATPase and gene expression in the rat of myocardial ischemia and reperfusion injury
- Chinese Acupuncture and Moxibustion Issue 3, Pages: 205-208(2007)
- 作者机构：
  
  1. 山西中医学院针灸推拿系
  2. 山西医科大学第二医院
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2007
- 稿件说明：
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Effects of acupuncture at the points of the Pericardium Meridian on the activity of myocardial Ca~(2+)-ATPase and gene expression in the rat of myocardial ischemia and reperfusion injury[J]. Chinese Acupuncture and Moxibustion, 2007, (3): 205-208.
DOI：

Effects of acupuncture at the points of the Pericardium Meridian on the activity of myocardial Ca~(2+)-ATPase and gene expression in the rat of myocardial ischemia and reperfusion injury[J]. Chinese Acupuncture and Moxibustion, 2007, (3): 205-208. DOI：

摘要

目的:观察针刺心包经“内关”“郄门”穴治疗心肌缺血的作用机制。方法:将大鼠随机分为5组

假手术组、缺血-再灌注模型组、针刺“内关”治疗组、针刺“郄门”治疗组、针刺“支沟”对照组。后3组电针相应穴位20min后

结扎冠状动脉左前降支40min

心电图(ECG)监测

再电针穴位20min

松扎

恢复灌流60min

摘取心脏

取心室肌制备心肌细胞肌浆网

定磷法测定三磷酸腺苷酶(Ca2+-ATPase)活性的高低;用Northen-Blot方法测定肌浆网Ca2+-ATPasemRNA的相对含量。结果:模型组Ca2+-ATPase活性明显降低

Ca2+-ATPasemRNA的表达下降。针刺心包经“内关”穴组和“郄门”穴组Ca2+-ATPase活性和Ca2+-ATPase mRNA表达均发生明显变化

与模型组比较均有非常显著性意义(P<0.01)

针刺“支沟”穴组酶活性与基因的表达和模型组比较差异无显著性意义(P>0.05)。结论:针刺手厥阴心包经穴“内关”“郄门”穴可提高心肌细胞肌浆网Ca2+-ATPase的活性

促进Ca2+-ATPasemRNA基因的表达

减轻缺血再灌注损伤的程度

增强心肌的功能。

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