Study on expression of brain aging-relative genes HSP86 and HSP84 and effects of acupuncture in the SAMP10 mouse

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Study on expression of brain aging-relative genes HSP86 and HSP84 and effects of acupuncture in the SAMP10 mouse

更新时间：2023-05-10

- Study on expression of brain aging-relative genes HSP86 and HSP84 and effects of acupuncture in the SAMP10 mouse
- Chinese Acupuncture and Moxibustion Issue 4, Pages: 283-286(2006)
- 作者机构：
  
  天津中医学院第一附属医院老年病研究室,天津,300193
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- Published：2006
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Study on expression of brain aging-relative genes HSP86 and HSP84 and effects of acupuncture in the SAMP10 mouse[J]. Chinese Acupuncture and Moxibustion, 2006, (4): 283-286.
DOI：

Study on expression of brain aging-relative genes HSP86 and HSP84 and effects of acupuncture in the SAMP10 mouse[J]. Chinese Acupuncture and Moxibustion, 2006, (4): 283-286. DOI：

摘要

目的探讨针刺延缓衰老的作用机制。方法采用快速老化小鼠SAMP10、SAMR1为模型

运用RT-PCR和地高辛标记的非放射性Northern blot技术

观察8月龄SAMR1对照组、SAMP10对照组、SAMP10针刺组及SAMP10非穴位刺激组全脑、皮层和海马HSP84、HSP86基因表达的变化。结果SAMP10对照组小鼠热休克蛋白HSP84、HSP86在全脑、皮层、海马中的表达下调

针刺后表达上调并趋向于正常组。结论SAMP10小鼠脑衰老与热休克蛋白HSP84、HSP86基因表达异常有关

针刺可以通过调节HSP84、HSP86基因表达增强细胞保护、抑制细胞凋亡、抵抗氧化应激

从而起到延缓衰老的作用。

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