Effects of electroacupuncture at “Zusanli” (ST 36) on ERK1/2 phosphorylation in the dorsal horn of spinal cord of the rat

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Effects of electroacupuncture at “Zusanli” (ST 36) on ERK1/2 phosphorylation in the dorsal horn of spinal cord of the rat

更新时间：2023-05-10

- Effects of electroacupuncture at “Zusanli” (ST 36) on ERK1/2 phosphorylation in the dorsal horn of spinal cord of the rat
- Chinese Acupuncture and Moxibustion Issue 5, Pages: 362-366(2006)
- 作者机构：
  
  第四军医大学神经科学研究所
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2006
- 稿件说明：
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Effects of electroacupuncture at “Zusanli” (ST 36) on ERK1/2 phosphorylation in the dorsal horn of spinal cord of the rat[J]. Chinese Acupuncture and Moxibustion, 2006, (5): 362-366.
DOI：

Effects of electroacupuncture at “Zusanli” (ST 36) on ERK1/2 phosphorylation in the dorsal horn of spinal cord of the rat[J]. Chinese Acupuncture and Moxibustion, 2006, (5): 362-366. DOI：

摘要

目的:探讨针刺镇痛机理。方法:将动物随机分为5组:正常对照组、单纯电针组、福尔马林组、福尔马林加同侧电针组和福尔马林加对侧电针组。造模方式为大鼠右足后垫皮下注射4%福尔马林溶液100μL。电针刺激“足三里”穴

疏密波

频率2～15Hz

强度2～3mA

持续30min。1.5h后麻醉处死动物

制片观察。结果:正常对照组脊髓后角浅层仅见个别腰段脊髓磷酸化ERK1/2(pERK1/2)阳性细胞(6.45±1.05)个;单纯电针组在电针同侧的脊髓背角有少量阳性细胞出现(14.07±3.19)个;福尔马林模型组的同侧脊髓背侧角浅层有大量阳性细胞被激活(26.57±4.93)个

主要分布于Ⅰ和Ⅱ0层;模型加同侧电针治疗组阳性细胞数(20.79±5.21)个与福尔马林模型组比较有减少的趋势

但统计学差异无显著意义;模型加对侧电针治疗组的炎症侧脊髓背角的阳性细胞数(14.75±3.03)个较福尔马林模型组显著减少(P<0.05)。结论:电针抑制脊髓后角ERK1/2信号分子的磷酸化

可能与其镇痛效应的发生机制有关。

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