Effects of moxibustion at Feishu (BL 13) and Gaohuang (BL 43) on expression of TGF-β1 in the bleomycin -induced pulmonary fibrosis

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Effects of moxibustion at Feishu (BL 13) and Gaohuang (BL 43) on expression of TGF-β1 in the bleomycin -induced pulmonary fibrosis

更新时间：2023-05-10

- Effects of moxibustion at Feishu (BL 13) and Gaohuang (BL 43) on expression of TGF-β1 in the bleomycin -induced pulmonary fibrosis
- Chinese Acupuncture and Moxibustion Issue 11, (2005)
- 作者机构：
  
  1. 成都中医药大学
  2. 四川大学华西医学中心
  3. 成都理工大学
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Published：2005
- 稿件说明：
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Effects of moxibustion at Feishu (BL 13) and Gaohuang (BL 43) on expression of TGF-β1 in the bleomycin -induced pulmonary fibrosis[J]. Chinese Acupuncture and Moxibustion, 2005, (11).
DOI：

Effects of moxibustion at Feishu (BL 13) and Gaohuang (BL 43) on expression of TGF-β1 in the bleomycin -induced pulmonary fibrosis[J]. Chinese Acupuncture and Moxibustion, 2005, (11). DOI：

摘要

目的:探索针灸阻抑肺纤维化的效应机制

为针灸介入肺纤维化防治提供实验依据。方法:将SD大鼠140只随机分为4组:空白组、模型组、艾灸组、泼尼松组

每组35只。气管内注入博莱霉素制作大鼠肺纤维化模型

造模后7d开始治疗

以5mg艾绒灸其双侧“肺俞”“膏肓”

每穴3壮

每天1次

10d为一疗程

共治疗3个疗程后处死动物

采用PCR检测其转化生长因子β1(TGFβ1)mRNA表达。结果:肺组织TGFβ1mRNA表达分别为:空白组1.0258±0.0057

模型组2.8104±0.2905

艾灸组1.6174±0.1136

泼尼松组1.7176±0.1079。艾灸组、泼尼松组与模型组比较

P<0.01

艾灸组与泼尼松组比较

P>0.05。结论:艾灸“肺俞”“膏肓”与泼尼松治疗均能显著抑制肺纤维化大鼠肺组织TGFβ1mRNA表达。

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