Effect of electroacupuncture preconditioning on nitric oxide,nitric oxide synthase and oxyradical during hepatic ischemia-reperfusion injury in rabbits

doi:10.13703/j.0255-2930.2011.02.020

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Effect of electroacupuncture preconditioning on nitric oxide,nitric oxide synthase and oxyradical during hepatic ischemia-reperfusion injury in rabbits

更新时间：2023-05-10

- Effect of electroacupuncture preconditioning on nitric oxide,nitric oxide synthase and oxyradical during hepatic ischemia-reperfusion injury in rabbits
- Chinese Acupuncture and Moxibustion Vol. 31, Issue 2, Pages: 149-152(2011)
- 作者机构：
  
  1. 四川泸州医学院附属医院麻醉科
  2. 四川泸州医学院附属医院中医科
- 作者简介：
- 基金信息：
- DOI：10.13703/j.0255-2930.2011.02.020
  CLC：
- Published：2011
- 稿件说明：
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Effect of electroacupuncture preconditioning on nitric oxide,nitric oxide synthase and oxyradical during hepatic ischemia-reperfusion injury in rabbits[J]. Chinese Acupuncture and Moxibustion, 2011, 31(2): 149-152.
DOI：

Effect of electroacupuncture preconditioning on nitric oxide,nitric oxide synthase and oxyradical during hepatic ischemia-reperfusion injury in rabbits[J]. Chinese Acupuncture and Moxibustion, 2011, 31(2): 149-152. DOI： 10.13703/j.0255-2930.2011.02.020.

摘要

目的:探讨电针预处理对肝脏缺血再灌注损伤后的作用及作用机制。方法:24只国产大耳白兔

随机分为假手术(S)组、缺血再灌注(IR)组、电针预处理(EAP+IR)组

每组8只。EAP+IR组、IR组建立肝缺血再灌注损伤模型

EAP+IR组于术前电针刺激"阳陵泉"穴30 min。在缺血前及IR后8 h、24 h处死动物

取右肝叶进行一氧化氮(NO)及诱导型一氧化氮合酶(iNOS)测定

从耳缘动脉抽血2 mL行丙二醛(MDA)及超氧化物歧化酶(SOD)检测。结果:再灌注8 h、24 h后

EAP+IR组的NO为(0.491±0.102)μmol/g、(0.891±0.102)μmol/g

MDA为(5.94±0.35)μmol/L、(6.81±0.25)μmol/L

iNOS为(0.361±0.251)U/mg、(1.173±0.331)U/mg

活力较IR组明显下降[(0.756±0.087)μmol/g、(1.171±0.098)μmol/g、(6.36±0.21)μmol/L、(9.65±0.34)μmol/L、(0.692±0.223)U/mg、(1.711±0.323)U/mg](P<0.05

P<0.01)

SOD活力增加(P<0.01);与S组比较

EAP+IR及IR组NO、MDA含量及iNOS活力增加

SOD活力下降(均P<0.01)。结论:电针预处理可以抑制肝组织中iNOS的产生

降低NO、MDA含量

提高SOD活力

从而保护肝组织。

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