Effects of reinforcing and reducing methods by twirling and rotating the needle on contents of CGRP and NO in rats with stress-induced hypertension

doi:10.13703/j.0255-2930.2011.04.020

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Effects of reinforcing and reducing methods by twirling and rotating the needle on contents of CGRP and NO in rats with stress-induced hypertension

更新时间：2023-05-10

- Effects of reinforcing and reducing methods by twirling and rotating the needle on contents of CGRP and NO in rats with stress-induced hypertension
- Chinese Acupuncture and Moxibustion Vol. 31, Issue 4, Pages: 337-341(2011)
- 作者机构：
  
  1. 中国中医药国际合作中心
  2. 国家康复辅具研究中心
  3. 北京中医药大学
- 作者简介：
- 基金信息：
- DOI：10.13703/j.0255-2930.2011.04.020
  CLC：
- Published：2011
- 稿件说明：
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Effects of reinforcing and reducing methods by twirling and rotating the needle on contents of CGRP and NO in rats with stress-induced hypertension[J]. Chinese Acupuncture and Moxibustion, 2011, 31(4): 337-341.
DOI：

Effects of reinforcing and reducing methods by twirling and rotating the needle on contents of CGRP and NO in rats with stress-induced hypertension[J]. Chinese Acupuncture and Moxibustion, 2011, 31(4): 337-341. DOI： 10.13703/j.0255-2930.2011.04.020.

摘要

目的:探讨捻转补泻手法对应激性高血压大鼠的效应差异及其作用机制。方法:雄性Wistar大鼠60只

随机分为5组

每组12只

分别为正常组(A)、模型对照组(B)、针刺对照组(C)、针刺补法组(D)、针刺泻法组(E)。应激性高血压大鼠造模成功后

C组针刺左侧"太冲"穴

不行针

不做手法;D组针刺左侧"太冲"穴并用捻转补法;E组针刺左侧"太冲"穴并用捻转泻法。A、B两组大鼠不做针刺处理。7日后观察各组大鼠血浆及下丘脑降钙素基因相关肽(CGRP)、一氧化氮(NO)含量的变化。结果:针刺处理后

对大鼠血浆、下丘脑CGRP含量的影响:B组血浆CGRP含量为(261.0±20.1)pg/mL、下丘脑CGRP含量为(156.0±21.8)pg/mg

C组分别为(255.3±33.6)pg/mL、(154.3±47.3)pg/mg

两组与A组的(375.9±36.5)pg/mL、(213.6±50.1)pg/mg比较

CGRP含量下降(均P<0.05);E组的(465.9±53.2)pg/mL、(250.74±47.7)pg/mg与C组及D组的(283.3±29.8)pg/mL、(164.6±47.4)pg/mg比较

CGRP含量明显升高(均P<0.05)。C组与B组、D组比较

CGRP含量无明显变化(均P>0.05)。对大鼠血浆、下丘脑NO含量的影响:B组分别为(43.7±5.5)μmol/L、(23.3±2.9)μmol/g

C组为(46.5±6.4)μmol/L、(23.1±3.3)μmol/g

D组为(45.8±6.7)μmol/L、(25.0±2.7)μmol/g

3组分别与A组的(64.5±9.9)μmol/L、(30.7±1.6)μmol/g比较

NO含量下降(均P<0.05);E组的(55.9±4.6)μmol/L、(30.4±2.1)μmol/g与C组及D组比较

NO含量升高(均P<0.05)。C组与B组、D组比较

NO含量变化差异无统计学意义(均P>0.05)。结论:针刺泻法可以有效地升高应激性高血压大鼠CGRP、NO含量

从而降低其血压

针刺补法对应激性高血压大鼠降压作用不明显。捻转补法与泻法具有不同的效应。

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