Effect of pre-electroacupuncture at "Zusanli" (ST 36) on DA and 5-HT contents and their ratio in hypothalamus and striatum in exercise rats

doi:10.13703/j.0255-2930.2011.12.018

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Effect of pre-electroacupuncture at "Zusanli" (ST 36) on DA and 5-HT contents and their ratio in hypothalamus and striatum in exercise rats

更新时间：2023-05-10

- Effect of pre-electroacupuncture at "Zusanli" (ST 36) on DA and 5-HT contents and their ratio in hypothalamus and striatum in exercise rats
- Chinese Acupuncture and Moxibustion Vol. 31, Issue 12, Pages: 1101-1105(2011)
- 作者机构：
  
  1. 浙江中医药大学第三临床医学院
  2. 浙江中医药大学附属第三医院
  3. 浙江省中西医结合医院
- 作者简介：
- 基金信息：
- DOI：10.13703/j.0255-2930.2011.12.018
  CLC：
- Published：2011
- 稿件说明：
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Effect of pre-electroacupuncture at "Zusanli" (ST 36) on DA and 5-HT contents and their ratio in hypothalamus and striatum in exercise rats[J]. Chinese Acupuncture and Moxibustion, 2011, 31(12): 1101-1105.
DOI：

Effect of pre-electroacupuncture at "Zusanli" (ST 36) on DA and 5-HT contents and their ratio in hypothalamus and striatum in exercise rats[J]. Chinese Acupuncture and Moxibustion, 2011, 31(12): 1101-1105. DOI： 10.13703/j.0255-2930.2011.12.018.

摘要

目的:观察逆电针"足三里"穴对急性跑台运动大鼠的抗疲劳效应及其中枢机制。方法:将清洁级雄性SD大鼠50只随机分为安静组(n=10)、模型组(n=20)和逆电针组(n=20)

后两组又分为运动后即刻、运动后3h组(各10只)。后两组大鼠完成适应性跑台运动后

接受急性跑台运动;逆电针组大鼠于跑台运动前先介入电针治疗(参数为双侧"足三里"穴、连续波、频率2Hz、强度2mA、时间30min、1次/d、连续6d)。分别于运动后即刻和运动后3h处死大鼠

检测血浆乳酸水平、下丘脑和纹状体多巴胺(DA)、5-羟色按(5-HT)含量变化

并计算DA/5-HT比值。结果:与安静组相比

模型组大鼠血浆乳酸和下丘脑5-HT水平呈升高趋势

下丘脑DA含量则显著升高(P<0.01);而纹状体DA和5-HT含量于运动后3h时显著降低(均P<0.01)。运动后即刻时

与同期模型组相比

逆电针组大鼠下丘脑DA和5-HT含量显著升高(均P<0.01)

而纹状体则明显下降(均P<0.01);运动后3h时

与同期模型组相比

逆电针组大鼠血浆乳酸水平、下丘脑5-HT含量均显著降低(P<0.05

P<0.01)

而下丘脑DA/5-HT比值则明显升高(P<0.01)。结论:逆电针"足三里"穴可促进急性跑台运动大鼠疲劳恢复

可能是通过降低跑台运动大鼠血浆乳酸堆积

提高下丘脑DA/5-HT比值发挥作用。

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