Expressions of neurotransmitters in patients of insomnia differentiated as liver stagnation transforming into fire treated with acupuncture

doi:10.13703/j.0255-2930.2015.06.005

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Expressions of neurotransmitters in patients of insomnia differentiated as liver stagnation transforming into fire treated with acupuncture

更新时间：2023-05-10

- Expressions of neurotransmitters in patients of insomnia differentiated as liver stagnation transforming into fire treated with acupuncture
- Chinese Acupuncture and Moxibustion Vol. 35, Issue 6, Pages: 549-552(2015)
- 作者机构：
  
  无锡市精神卫生中心中西医结合精神科
- 作者简介：
- 基金信息：
- DOI：10.13703/j.0255-2930.2015.06.005
  CLC：
- Published：2015
- 稿件说明：
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Expressions of neurotransmitters in patients of insomnia differentiated as liver stagnation transforming into fire treated with acupuncture[J]. Chinese Acupuncture and Moxibustion, 2015, 35(6): 549-552.
DOI：

Expressions of neurotransmitters in patients of insomnia differentiated as liver stagnation transforming into fire treated with acupuncture[J]. Chinese Acupuncture and Moxibustion, 2015, 35(6): 549-552. DOI： 10.13703/j.0255-2930.2015.06.005.

摘要

目的:比较针刺与药物曲唑酮治疗肝郁化火型不寐患者的疗效差异及其对不同神经递质表达的影响。方法:将70例确诊为肝郁化火型不寐患者随机分为观察组和对照组

每组35例。观察组采用针刺疗法

穴取神门、百会、印堂、合谷、太冲等

每次留针20min

每日1次

2周为一疗程

治疗2个疗程;对照组口服曲唑酮治疗

100mg

每日1次

2周为一疗程

治疗2个疗程。比较两组患者治疗前后匹兹堡睡眠质量指数(PSQI)、Asberg副作用量表评分(SERS)、5-羟色胺(5-HT)、去甲肾上腺素(NE)等神经递质含量以及外周血蛋白激酶C(PKC)、脑源性神经营养因子(BDNF)基因表达水平。结果:两组治疗后PSQI、SERS评分均较治疗前明显降低(均P<0.05)

治疗后

观察组患者PSQI评分、SERS评分明显低于对照组(均P<0.05);两组治疗后血清NE含量、PKC水平明显降低

血清5-HT含量、BDNF mRNA表达明显增高(均P<0.05);观察组NE含量、PKC水平明显低于对照组(P<0.05);观察组血清5-HT含量及BDNF mRNA表达明显高于对照组(均P<0.05)。结论:针刺疗法能够改善肝郁化火型不寐患者的睡眠质量

同时降低患者血清NE

提高5-HT

增加BDNF表达

其作用均优于西药曲唑酮

是肝郁化火型不寐的有效治疗手段之一。

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