Effect of acupuncture technique of Tiaoxin Tongdu on learning-memory ability and expressions of hippocampal VEGF and Ang-1 in rats with vascular dementia

doi:10.13703/j.0255-2930.20190821-0008

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Effect of acupuncture technique of Tiaoxin Tongdu on learning-memory ability and expressions of hippocampal VEGF and Ang-1 in rats with vascular dementia

更新时间：2023-05-10

- Effect of acupuncture technique of Tiaoxin Tongdu on learning-memory ability and expressions of hippocampal VEGF and Ang-1 in rats with vascular dementia
- Chinese Acupuncture and Moxibustion Vol. 40, Issue 10, Pages: 1108-1112(2020)
- 作者机构：
  
  1. 湖南中医药大学针灸推拿学院
  2. 湖南中医药大学附属第二医院针灸科
- 作者简介：
- 基金信息：
- DOI：10.13703/j.0255-2930.20190821-0008
  CLC：
- Published：2020
- 稿件说明：
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Effect of acupuncture technique of Tiaoxin Tongdu on learning-memory ability and expressions of hippocampal VEGF and Ang-1 in rats with vascular dementia[J]. Chinese Acupuncture and Moxibustion, 2020, 40(10): 1108-1112.
DOI：

Effect of acupuncture technique of Tiaoxin Tongdu on learning-memory ability and expressions of hippocampal VEGF and Ang-1 in rats with vascular dementia[J]. Chinese Acupuncture and Moxibustion, 2020, 40(10): 1108-1112. DOI： 10.13703/j.0255-2930.20190821-0008.

摘要

目的:观察"调心通督"针刺法对血管性痴呆(VD)大鼠学习记忆能力及海马组织血管内皮生长因子(VEGF)、血管生成素-1(Ang-1)蛋白表达的影响

探讨"调心通督"针刺法治疗VD的作用机制。方法:24只雄性SD大鼠行Morris水迷宫实验后随机分为假手术组、模型组、西药对照组和调心通督针刺组

每组6只。模型组、西药对照组、调心通督针刺组大鼠采用双侧颈总动脉永久性结扎法复制VD模型。造模成功次日开始干预

调心通督针刺组选取"百会""神庭""水沟""大椎""风府""命门""内关""大陵""劳宫"进行针刺干预

每次30 min;西药对照组予尼莫地平溶液(0.0625 g/kg)灌胃

均每日1次

共干预2周。造模前、造模2周后及干预后采用Morris水迷宫实验对大鼠进行行为学检测;干预后

采用Western blot法检测大鼠海马组织VEGF、Ang-1蛋白表达。结果:与假手术组比较

模型组大鼠平均逃避潜伏期延长(P<0.01)

穿越原平台次数减少(P<0.01);与模型组比较

西药对照组、调心通督针刺组大鼠干预后平均逃避潜伏期缩短(P<0.01)

穿越原平台次数增加(P<0.01

P<0.05)。与假手术组比较

模型组大鼠海马组织VEGF、Ang-1蛋白表达均升高(P<0.01

P<0.05);与模型组比较

西药对照组、调心通督针刺组大鼠海马组织VEGF、Ang-1蛋白表达均升高(P<0.01

P<0.05)。结论:"调心通督"针刺法能明显改善VD大鼠学习记忆能力

其机制可能与上调海马组织VEGF、Ang-1蛋白表达

诱导血管新生有关。

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