Effect of moxibustion on inflammatory factors and oxidative stress factors in patients with knee osteoarthritis: a randomized controlled trial

doi:10.13703/j.0255-2930.20200310-k0011

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Effect of moxibustion on inflammatory factors and oxidative stress factors in patients with knee osteoarthritis: a randomized controlled trial

更新时间：2023-05-10

- Effect of moxibustion on inflammatory factors and oxidative stress factors in patients with knee osteoarthritis: a randomized controlled trial
- Chinese Acupuncture and Moxibustion Vol. 40, Issue 9, Pages: 913-917(2020)
- 作者机构：
  
  1. 河北中医学院基础医学院
  2. 河北中医学院针灸推拿学院
- 作者简介：
- 基金信息：
- DOI：10.13703/j.0255-2930.20200310-k0011
  CLC：
- Published：2020
- 稿件说明：
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Effect of moxibustion on inflammatory factors and oxidative stress factors in patients with knee osteoarthritis: a randomized controlled trial[J]. Chinese Acupuncture and Moxibustion, 2020, 40(9): 913-917.
DOI：

Effect of moxibustion on inflammatory factors and oxidative stress factors in patients with knee osteoarthritis: a randomized controlled trial[J]. Chinese Acupuncture and Moxibustion, 2020, 40(9): 913-917. DOI： 10.13703/j.0255-2930.20200310-k0011.

摘要

目的:比较艾灸与针刺治疗膝骨关节炎(KOA)的临床疗效

并观察其对患者血清肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)、超氧化物歧化酶(SOD)、丙二醛(MDA)的影响。方法:将60例KOA患者随机分为艾灸组(30例

脱落2例)和针刺组(30例

脱落2例)。针刺组穴取患侧内膝眼、犊鼻、鹤顶、血海、梁丘、足三里、阿是穴行针刺治疗

留针30 min;艾灸组采用艾灸箱于膝关节局部进行治疗

每次60 min

两组治疗均每两天1次

连续4周

共计14次。比较两组患者治疗前后西安大略和麦克马斯特大学骨关节炎指数(WOMAC)评分

并评定疗效;检测两组患者治疗前后血清TNF-α、IL-1β、MDA含量及血清SOD活力。结果:与治疗前比较

治疗后两组患者WOMAC评分

血清TNF-α、IL-1β及MDA含量均降低(P<0.05);SOD活力均增高(P<0.05)。与针刺组比较

艾灸组患者治疗后WOMAC评分

血清TNF-α、IL-1β及MDA含量较低(P<0.05);SOD活力较高(P<0.05)。艾灸组总有效率为89.3%(25/28)

优于针刺组的42.9%(12/28

P<0.05)。结论:艾灸和针刺治疗均能减轻KOA症状

且艾灸疗效优于针刺

其作用机制可能与降低患者血清炎性因子和氧化应激因子水平有关。

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