Correlation between curative effect and 5-HTTLPR polymorphism in treatment of diarrhea-predominant irritable bowel syndrome with acupuncture for regulating shen and strengthening spleen

doi:10.13703/j.0255-2930.20200313-k0002

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Correlation between curative effect and 5-HTTLPR polymorphism in treatment of diarrhea-predominant irritable bowel syndrome with acupuncture for regulating shen and strengthening spleen

更新时间：2023-05-10

- Correlation between curative effect and 5-HTTLPR polymorphism in treatment of diarrhea-predominant irritable bowel syndrome with acupuncture for regulating shen and strengthening spleen
- Chinese Acupuncture and Moxibustion Vol. 41, Issue 4, Pages: 365-370(2021)
- 作者机构：
  
  1. 南京中医药大学附属医院针灸康复科
  2. 沭阳县中医院针灸科
  3. 南通市中医院针灸科
  4. 无锡市中医医院针灸科
- 作者简介：
- 基金信息：
- DOI：10.13703/j.0255-2930.20200313-k0002
  CLC：
- Published：2021
- 稿件说明：
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Correlation between curative effect and 5-HTTLPR polymorphism in treatment of diarrhea-predominant irritable bowel syndrome with acupuncture for regulating shen and strengthening spleen[J]. Chinese Acupuncture and Moxibustion, 2021, 41(4): 365-370.
DOI：

Correlation between curative effect and 5-HTTLPR polymorphism in treatment of diarrhea-predominant irritable bowel syndrome with acupuncture for regulating shen and strengthening spleen[J]. Chinese Acupuncture and Moxibustion, 2021, 41(4): 365-370. DOI： 10.13703/j.0255-2930.20200313-k0002.

摘要

目的:比较"调神健脾"针刺与匹维溴铵片治疗腹泻型肠易激综合征(IBS-D)的疗效

从5-羟色胺转运体基因多态性区(5-HTTLPR)基因多态性角度探讨针刺疗效的相关机制。方法:将231例IBS-D患者按照2∶1的比例随机分为针刺组(154例)和西药组(77例)。针刺组予"调神健脾"组方针刺

穴取百会、印堂、天枢、上巨虚、足三里等

隔日1次

每周3次;西药组口服匹维溴铵片

每次50 mg

每日3次

均治疗6周。分别于治疗前、治疗后及3个月随访期评价两组IBS症状严重程度量表(IBS-SSS)与IBS生活质量量表(IBS-QOL)总分

于治疗后比较两组疗效及安全性;在治疗前测定患者5-HTTLPR基因型。结果:治疗后及随访时

两组患者IBS-SSS总分均较治疗前降低(P<0.01)

且针刺组低于西药组(P<0.01);治疗后及随访时

两组患者IBS-QOL总分均较治疗前升高(P<0.01)

且针刺组随访时高于西药组(P<0.01)。针刺组总有效率为79.2%(122/154)

高于西药组的58.4%(45/77

P<0.01)

两组均未出现严重不良反应。针刺组LS及SS基因型患者IBS-SSS总分治疗前后差值均大于LL基因型(P<0.01);西药组SS基因型患者IBS-SSS总分治疗前后差值大于LL基因型(P<0.01);针刺组LS及SS基因型患者IBS-SSS总分治疗前后差值均大于西药组同基因型(P<0.01)。结论:"调神健脾"针刺治疗腹泻型肠易激综合征的疗效优于匹维溴铵片

可有效缓解患者临床症状

改善患者生活质量

具有较好的疗效及安全性;针刺临床疗效与5-HTTLPR基因多态性具有相关性

LS、SS基因型患者针刺治疗的疗效可能更优。

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