Abdominal acupoint thread embedding therapy based on "brain-intestinal connection" for mild-to-moderate Alzheimer's disease and its effects on serum levels of APP and Aβ_(1-42)

doi:10.13703/j.0255-2930.20201106-k0002

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Abdominal acupoint thread embedding therapy based on "brain-intestinal connection" for mild-to-moderate Alzheimer's disease and its effects on serum levels of APP and Aβ_(1-42)

更新时间：2023-05-10

- Abdominal acupoint thread embedding therapy based on "brain-intestinal connection" for mild-to-moderate Alzheimer's disease and its effects on serum levels of APP and Aβ_(1-42)
- Chinese Acupuncture and Moxibustion Vol. 41, Issue 11, Pages: 1231-1235(2021)
- 作者机构：
  
  1. 广州中医药大学第五临床医学院
  2. 广东省第二中医院针灸科
- 作者简介：
- 基金信息：
- DOI：10.13703/j.0255-2930.20201106-k0002
  CLC：
- Published：2021
- 稿件说明：
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Abdominal acupoint thread embedding therapy based on "brain-intestinal connection" for mild-to-moderate Alzheimer's disease and its effects on serum levels of APP and Aβ_(1-42)[J]. Chinese Acupuncture and Moxibustion, 2021, 41(11): 1231-1235.
DOI：

Abdominal acupoint thread embedding therapy based on "brain-intestinal connection" for mild-to-moderate Alzheimer's disease and its effects on serum levels of APP and Aβ_(1-42)[J]. Chinese Acupuncture and Moxibustion, 2021, 41(11): 1231-1235. DOI： 10.13703/j.0255-2930.20201106-k0002.

摘要

目的:比较基于"脑肠相通"理论的腹针埋线疗法联合盐酸多奈哌齐片与单纯口服盐酸多奈哌齐片治疗轻中度阿尔茨海默病(AD)患者的临床疗效及对血清β淀粉样蛋白(Aβ)前体蛋白(APP)、Aβ_(1-42)的影响。方法:将60例AD患者随机分为观察组(30例

脱落3例)和对照组(30例

脱落3例)。对照组患者口服盐酸多奈哌齐片(每天5 mg);观察组患者在对照组基础上予腹针埋线疗法

穴取中脘、下脘、滑肉门、外陵、大横等

每10天1次

两组均治疗2个月。观察两组患者治疗前后简易精神状态检查量表(MMSE)、AD认知评定量表(ADAS-Cog)、日常生活能力量表(ADL)、神经精神问卷(NPI)评分及血清APP、Aβ_(1-42)水平。结果:治疗后

两组患者MMSE评分较治疗前升高(P<0.05)

ADAS-Cog、ADL、NPI评分较治疗前降低(P<0.05);观察组患者治疗后MMSE评分高于对照组(P<0.05)

ADAS-Cog、ADL、NPI评分低于对照组(P<0.05)。治疗后

两组患者血清APP、Aβ_(1-42)水平较治疗前降低(P<0.05)

且观察组低于对照组(P<0.05)。结论:基于"脑肠相通"理论的腹针埋线疗法联合盐酸多奈哌齐片可改善轻中度AD患者的认知功能、日常生活自理能力及精神行为状态

降低血清APP、Aβ_(1-42)水平

其临床疗效优于单纯口服盐酸多奈哌齐片。

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