Objective To identify the key outcome indexes in treatment of migraine with acupuncture and moxibustion.Methods Using literature research

questionnaire survey and consensus conference

the key outcome indexes in treatment of migraine with acupuncture and moxibustion were screened and prioritized. Results The critical outcome indexes for the treatment in attack stage of migraine included 6 effectiveness outcome indexes（headache intensity

headache duration

headache relieve time

effectiveness and level of headache relief within 2 h

headache-related quality of life

level of headache relief within 24 h） and 1 safety outcome index（incidence of serious adverse reactions）. The critical outcome indexes for prophylactic treatment included 6 effectiveness outcome indexes（headache day

headache frequency

headache intensity

effective rate

headache-related quality of life

health-related quality of life） and 1 safety outcome index（incidence of serious adverse reactions）. Conclusion In terms of the attack stage treatment and prophylactic treatment with acupuncture and moxibustion

the outcome indexes are different

among which

those can directly reflect the conditions of migraine should be optioned in priority. To assess the effectiveness of attack stage

the headache intensity is preferred

using the visual analogue scale（VAS） score

and the preferred time is 2 hours after treatment. Regarding the effectiveness of prophylactic treatment

the headache day

headache frequency and headache intensity should be firstly considered in the assessment

in which

the preferred time for assessment is 12 weeks into treatment

while

the best time for follow-up should be 12 weeks after treatment completion. When the quality of life is considered

the migraine-specific quality of life questionnaire（MSQ） is the top option. For either the attack stage treatment or the prophylactic treatment

the high attention should be laid on the outcome indexes for safety and medical economics evaluation.