Objective To investigate the clinical effect of aconite-isolated moxibustion at Yongquan（KI 1） combined with rivaroxaban for lower extremity venous thrombosis after total knee arthroplasty and the influence on hypercoagulation.Methods Seventy-three patients of knee osteoarthritis with lower extremity venous thrombosis after total knee arthroplasty（KOA） were randomly divided into an observation group（37 cases

2 cases dropped off） and a control group（36 cases

1 case dropped off）. The patients in the control group took orally rivaroxaban tablets

10 mg a time

once a day. On the basis of the treatment as the control group

the aconite-isolated moxibustion was applied to Yongquan（KI 1） for the patients of the observation group

once daily and 3 moxa cones were used in each treatment. The duration of treatment was 14 days in both groups. Before treatment and 14 days into treatment

the ultrasonic B test was adopted to determine the conditions of lower extremity venous thrombosis in the two groups. Before treatment

7 and 14 days into treatment

the coagulation indexes（platelet [PLT]

prothrombin time [PT]

activated partial prothrombin time [APTT]

fibrinogen [Fib] and D-dimer[D-D]）

the blood flow velocity of the deep femoral vein and the circumference of the affected side were compared between the two groups separately

and the clinical effect was evaluated. Results Fourteen days into treatment

the venous thrombosis of the lower extremity was relieved in both groups（P<0.05）

and that of the observation group was better than the control group（P<0.05）.Seven days into treatment

the blood flow velocity of the deep femoral vein was increased compared with that before treatment in the observation group（P<0.05）

and the blood flow rate in the observation group was higher than that in the control group（P<0.05）. Fourteen days into treatment

PT

APTT and the blood flow velocity of the deep femoral vein were increased in the two groups compared with those before treatment（P<0.05）; and PLT

Fib

D-D and the circumference of the limb（knee joint

10 cm above the patella and 10 cm below the patella） were all reduced in the two groups（P<0.05）. Compared with the control group 14 days into treatment

the blood flow velocity of the deep femoral vein was higher（P<0.05）

PLT

Fib

D-D and the circumference of the limb（knee joint

10 cm above the patella and 10 cm below the patella） were all lower in the observation group（P<0.05）. The total effective rate was 97.1%（34/35） in the observation group

higher than 85.7%（30/35） in the control group（P<0.05）. Conclusion Aconite-isolated moxibustion at Yongquan（KI 1） combined with rivaroxaban can effectively treat lower extremity venous thrombosis after total knee arthroplasty

relieve hypercoagulation

accelerate the blood flow velocity and alleviate swelling of the lower extremity in the patients with knee osteoarthritis.