Tiaoshen Jieyu acupuncture combined with sertraline hydrochloride tablet for post-stoke depression: a randomized controlled trial

doi:10.13703/j.0255-2930.20220520-0006

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Tiaoshen Jieyu acupuncture combined with sertraline hydrochloride tablet for post-stoke depression: a randomized controlled trial

更新时间：2023-05-10

- Tiaoshen Jieyu acupuncture combined with sertraline hydrochloride tablet for post-stoke depression: a randomized controlled trial
- Chinese Acupuncture and Moxibustion Vol. 43, Issue 1, Pages: 19-22(2023)
- 作者机构：
  
  南京中医药大学附属医院针灸康复科
- 作者简介：
- 基金信息：
- DOI：10.13703/j.0255-2930.20220520-0006
  CLC： R743.3
- Published：2023
- 稿件说明：
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Tiaoshen Jieyu acupuncture combined with sertraline hydrochloride tablet for post-stoke depression: a randomized controlled trial[J]. Chinese Acupuncture and Moxibustion, 2023, 43(1): 19-22.
DOI：

Tiaoshen Jieyu acupuncture combined with sertraline hydrochloride tablet for post-stoke depression: a randomized controlled trial[J]. Chinese Acupuncture and Moxibustion, 2023, 43(1): 19-22. DOI： 10.13703/j.0255-2930.20220520-0006.

摘要

目的：比较调神解郁法针刺联合盐酸舍曲林片与单纯盐酸舍曲林片治疗卒中后抑郁（PSD）的临床疗效。方法：将76例PSD患者随机分为观察组（38例，脱落6例）和对照组（38例，脱落4例）。两组均予控制血压、抗炎等常规治疗，对照组予口服盐酸舍曲林片治疗，每次20mg，每日1次；观察组在对照组基础上联合调神解郁法针刺治疗，穴取百会、印堂、内关、太冲等，百会、印堂连接电针，予疏密波，频率2 Hz/100 Hz，每次30 min，每天1次，每周6次，两组均治疗8周。分别于治疗前后观察两组患者汉密尔顿抑郁量表（HAMD）、美国国立卫生研究院卒中量表（NIHSS）、Barthel指数（BI）和匹兹堡睡眠质量指数（PSQI）评分，并评定两组患者临床疗效及不良反应发生率。结果：治疗后，两组患者HAMD、NIHSS、PSQI评分均低于治疗前（P<0.05）

BI评分高于治疗前（P<0.05）；观察组患者HAMD、NIHSS、PSQI评分均低于对照组（P<0.05）

BI评分高于对照组（P<0.05）。观察组总有效率为93.8%(30/32)，高于对照组的70.6%(24/34

P<0.05)。观察组不良反应发生率为9.4%(3/32)，低于对照组的32.4%(11/34

P<0.05)。结论：调神解郁法针刺联合盐酸舍曲林片可有效改善PSD患者抑郁情绪、神经功能、日常生活活动能力及睡眠质量，临床疗效优于单纯盐酸舍曲林片，且可减轻药物不良反应。

Abstract

Objective To compare the clinical efficacy between Tiaoshen Jieyu acupuncture（acupuncture for regulating mind and relieving depression） combined with sertraline hydrochloride tablet and simple sertraline hydrochloride tablet for post-stroke depression（PSD）. Methods A total of 76 patients with PSD were randomized into an observation group（38 cases

6 cases dropped off） and a control group（38 cases

4 cases dropped off）. Both groups were treated with conventional treatment i.e. controlling blood pressure and anti-inflammation. Sertraline hydrochloride tablet was given orally in the control group

20 mg a time

once a day. On the basis of the treatment in the control group

Tiaoshen Jieyu acupuncture was applied at Baihui（GV 20）

Yintang（GV 24+）

Neiguan（PC 6）

Taichong（LR 3）

etc. in the observation group

Baihui（GV 20） and Yintang（GV 24+） were connected to electroacupuncture

with disperse-dense wave

2 Hz/100 Hz in frequency

30 min a time

once a day

6 times a week. Treatment of 8 weeks was required in both groups. Before and after treatment

the scores of Hamilton depression scale（HAMD）

National Institutes of Health stroke scale（NIHSS）

Barthel index（BI） and Pittsburgh sleep quality index（PSQI） were observed respectively

the therapeutic efficacy and rate of adverse reactions were evaluated in the two groups. Results After treatment

the scores of HAMD

NIHSS and PSQI were lower while BI scores were higher than those before treatment in both groups（P<0.05）; the scores of HAMD

NIHSS and PSQI in the observation group were lower while BI score was higher than those in the control group（P<0.05）. The total effective rate was 93.8%（30/32） in the observation group

which was higher than 70.6%（24/34） in the control group（P<0.05）. The rate of adverse reactions was 9.4%（3/32） in the observation group

which was lower than 32.4%（11/34） in the control group（P<0.05）.Conclusion Tiaoshen Jieyu acupuncture combined with sertraline hydrochloride tablet can improve the depression degree

neurological function

activity of daily living and sleep quality in patients with post-stroke depression

the clinical efficacy is superior to simple sertraline hydrochloride

and can alleviate the adverse reactions caused by medication.

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