Current research status and reflection on acupuncture treatment for brain disorders

WANG Feixue; LI Kaixin; ZHANG Meng; YAN Jinglan; YAO Lin; WANG Taiyi; CHEN Yongjun

doi:10.13703/j.0255-2930.20221121-k0003

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Current research status and reflection on acupuncture treatment for brain disorders

Review | 更新时间：2024-06-03

- Current research status and reflection on acupuncture treatment for brain disorders
- Chinese Acupuncture & Moxibustion Vol. 44, Issue 2, Pages: 239-244(2024)
- 作者机构：
  
  山东中医药大学针灸研究院，济南250355
- 作者简介：
- 基金信息：
- DOI：10.13703/j.0255-2930.20221121-k0003
  CLC：
- Received：21 November 2022，
  
  Online First：18 December 2023，
  
  Published：12 February 2024
- 稿件说明：
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王飞雪,李凯欣,张猛等.针灸治疗脑病的研究现状与思考[J].中国针灸,2024,44(02):239-244.

WANG Feixue,LI Kaixin,ZHANG Meng,et al.Current research status and reflection on acupuncture treatment for brain disorders[J].Chinese Acupuncture & Moxibustion,2024,44(02):239-244.
王飞雪,李凯欣,张猛等.针灸治疗脑病的研究现状与思考[J].中国针灸,2024,44(02):239-244. DOI： 10.13703/j.0255-2930.20221121-k0003.

WANG Feixue,LI Kaixin,ZHANG Meng,et al.Current research status and reflection on acupuncture treatment for brain disorders[J].Chinese Acupuncture & Moxibustion,2024,44(02):239-244. DOI： 10.13703/j.0255-2930.20221121-k0003.

摘要

针灸在脑病治疗中确有疗效，如何实现针灸与现代化技术的结合，促进针灸在脑病临床治疗上的应用，阐明针灸防治脑病的机制，加快针灸医学转化发展的步伐是针灸研究领域面临的巨大的挑战。本文简述针灸治疗脑病的研究现状、问题及未来可能发展方向，以期为针灸治疗脑病的现代化发展提供重要参考。

Abstract

Acupuncture has demonstrated positive efficacy in the treatment of brain disorders. However

significant challenges lie in integrating acupuncture with modern technologies

promoting its clinical application in treating brain disorders

elucidating the mechanisms underlying acupuncture's preventive and therapeutic effects on brain disorders

and accelerating the pace of translational development in acupuncture medicine. This paper briefly outlines the current research status

challenges

and potential future directions in acupuncture treatment for brain disorders

aiming to provide essential insights for the modernization and development of acupuncture in the treatment of brain disorders.

关键词

Keywords

references

Launch of first WHO position paper on optimizing brain health across life [EB/OL ] . [ 2022-10-03 ] . https://www.who.int/news/item/09-08-2022-launch-of-first-who-position-paper-on-optimizing-brain-health-across-life https://www.who.int/news/item/09-08-2022-launch-of-first-who-position-paper-on-optimizing-brain-health-across-life .

GBD Neurology Collaborators . Global, regional, and national burden of neurological disorders, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016 [J ] . Lancet Neurol , 2019 , 18 ( 5 ): 459 - 480 .

Wu CY , Yang LM , Feng S , et al . Therapeutic non-invasive brain treatments in Alzheimer's disease: recent advances and challenges [J ] . Inflamm Regen , 2022 , 42 ( 1 ): 31 .

Cao M , Galvis D , Vogrin SJ , et al . Virtual intracranial EEG signals reconstructed from MEG with potential for epilepsy surgery [J ] . Nat Commun , 2022 , 13 ( 1 ): 994 .

Bakken TE , Jorstad NL , Hu QW , et al . Comparative cellular analysis of motor cortex in human, marmoset and mouse [J ] . Nature , 2021 , 598 ( 7879 ): 111 - 119 .

Liu Z , Li X , Zhang JT , et al . Autism-like behaviours and germline transmission in transgenic monkeys overexpressing MeCP2 [J ] . Nature , 2016 , 530 ( 7588 ): 98 - 102 .

Li YY , Fan TD , Li XF , et al . Npas3 deficiency impairs cortical astrogenesis and induces autistic-like behaviors [J ] . Cell Rep , 2022 , 41 ( 10 ): 111767 .

Sun XY , Cheng LX , Sun YH . Autism-associated protein POGZ controls ESCs and ESC neural induction by association with esBAF [J ] . Mol Autism , 2022 , 13 ( 1 ): 24 .

Poeppel D , Idsardi W . We don't know how the brain stores anything, let alone words [J ] . Trends Cogn Sci , 2022 , 26 ( 12 ): 1054 - 1055 .

How to design high quality acupuncture trials-a consensus informed by evidence [J ] . BMJ , 2022 , 377 : o1046 .

Zhang YQ , Lu LM , Xu NG , et al . Increasing the usefulness of acupuncture guideline recommendations [J ] . BMJ , 2022 , 376 : e070533 .

Lu LM , Zhang YQ , Tang XR , et al . Evidence on acupuncture therapies is underused in clinical practice and health policy [J ] . BMJ , 2022 , 376 : e067475 .

Fei YT , Cao HJ , Xia RY , et al . Methodological challenges in design and conduct of randomised controlled trials in acupuncture [J ] . BMJ , 2022 , 376 : e064345 .

Li HC , Jin XJ , Herman PM , et al . Using economic evaluations to support acupuncture reimbursement decisions: current evidence and gaps [J ] . BMJ , 2022 , 376 : e067477 .

Smith CA , Armour M , Lee MS , et al . Acupuncture for depression [J ] . Cochrane Database Syst Rev , 2018 , 3 ( 3 ): CD004046 .

Wang XF , Cai W , Wang YP , et al . Is electroacupuncture an effective and safe treatment for poststroke depression? An updated systematic review and meta-analysis [J ] . Biomed Res Int , 2021 , 2021 : 8661162 .

Kim SA , Lee SH , Kim JH , et al . Efficacy of acupuncture for insomnia: a systematic review and meta-analysis [J ] . Am J Chin Med , 2021 , 49 ( 5 ): 1135 - 1150 .

Wang LY , Pei J , Zhan YJ , et al . Overview of meta-analyses of five non-pharmacological interventions for Alzheimer's disease [J ] . Front Aging Neurosci , 2020 , 12 : 594432 .

张任 , 荣兵 , 李建 , 等 . 醒脑开窍针法对非痴呆性血管认知障碍的影响 [J ] . 中医杂志 , 2019 , 60 ( 12 ): 1046 - 1050 .

梅丽霞 . 通督调神针刺法辅助语言康复训练对中风后失语患者CRRCAE评分及血液流变学的影响 [J ] . 中医药临床杂志 , 2020 , 32 ( 8 ): 1498 - 1501 .

蔡娲 , 魏溪芳 , 张静若 , 等 . 调神疏肝针法结合百忧解改善卒中后抑郁症患者抑郁症状和神经功能的临床研究 [J ] . 针灸临床杂志 , 2022 , 38 ( 7 ): 15 - 19 .

刘爽 , 罗辑 , 刘煜洲 . “益智开窍”针法对脑卒中患者认知功能障碍的改善作用及对脑血流动力学的影响 [J ] . 针灸临床杂志 , 2021 , 37 ( 2 ): 36 - 39 .

杨惠钦 , 于涛 . 脐针治疗心脾两虚型失眠的临床研究 [J ] . 广州中医药大学学报 , 2022 , 39 ( 9 ): 2071 - 2076 .

李春香 . 揿针针刺治疗心脾两虚型不寐病的随机对照临床疗效研究 [J ] . 中西医结合心血管病电子杂志 , 2018 , 6 ( 11 ): 38 - 39 .

刘建 , 曾姿霈 , 苏美意 . 子午流注纳支法治疗失眠症临床观察 [J ] . 吉林中医药 , 2013 , 33 ( 10 ): 1058 - 1059 .

樊恩召 , 刘智斌 , 王强 , 等 . “嗅三针”治疗阿尔兹海默病优势之我见 [J ] . 辽宁中医杂志 , 2019 , 46 ( 10 ): 2156 - 2158 .

吴建丽 , 尹洪娜 , 王德龙 , 等 . 头针疗法的起源及发展现状 [J ] . 广州中医药大学学报 , 2019 , 36 ( 11 ): 1783 - 1787 .

于建春 , 曹晓君 , 刘云鹤 , 等 . 近十年三焦理论研究概述 [J ] . 中医杂志 , 2017 , 58 ( 19 ): 1621 - 1623, 1628 .

Zhang YP , Liao WJ , Xia WG . Effect of acupuncture cooperated with low-frequency repetitive transcranial magnetic stimulation on chronic insomnia: a randomized clinical trial [J ] . Curr Med Sci , 2018 , 38 ( 3 ): 491 - 498 .

袁宏伟 , 刘云霞 , 张含 , 等 . “通督醒神”法针灸联合认知训练治疗卒中后轻度认知障碍：随机对照试验 [J ] . 中国针灸 , 2022 , 42 ( 8 ): 839 - 843 .

何清平 , 季束玲 , 蒋宗庆 , 等 . 超声引导神经入肌点温针灸治疗对脑卒中患者步态与平衡功能影响的临床研究 [J ] . 中国康复医学杂志 , 2020 , 35 ( 9 ): 1114 - 1116 .

Song C , Wang H . Cytokines mediated inflammation and decreased neurogenesis in animal models of depression [J ] . Prog Neuro Psychopharmacol Biol Psychiatry , 2011 , 35 ( 3 ): 760 - 768 .

Xie LS , Liu Y , Zhang N , et al . Electroacupuncture improves M2 microglia polarization and Glia anti-inflammation of hippocampus in Alzheimer's disease [J ] . Front Neurosci , 2021 , 15 : 689629 .

Guo TW , Guo Z , Yang XJ , et al . The alterations of IL-1Beta, IL-6, and TGF-beta levels in hippocampal CA3 region of chronic restraint stress rats after electroacupuncture (EA) pretreatment [J ] . Evid Based Complement Alternat Med , 2014 , 2014 : 369158 .

Li K , Shi GQ , Zhao Y , et al . Electroacupuncture ameliorates neuroinflammation-mediated cognitive deficits through inhibition of NLRP3 in Presenilin1/2 conditional double knockout mice [J ] . Neural Plast , 2021 , 2021 : 8814616 .

Fries GR , Saldana VA , Finnstein J , et al . Molecular pathways of major depressive disorder converge on the synapse [J ] . Mol Psychiatry , 2023 , 28 ( 1 ): 284 - 297 .

Xie GL , Song CM , Lin XM , et al . Electroacupuncture regulates hippocampal synaptic plasticity via inhibiting Janus-activated kinase 2/signal transducer and activator of transcription 3 signaling in cerebral ischemic rats [J ] . J Stroke Cerebrovasc Dis , 2019 , 28 ( 3 ): 792 - 799 .

Han XK , Wu HG , Yin P , et al . Electroacupuncture restores hippocampal synaptic plasticity via modulation of 5-HT receptors in a rat model of depression [J ] . Brain Res Bull , 2018 , 139 : 256 - 262 .

Guo LL , Liang XM , Liang ZM , et al . Electroacupuncture ameliorates cognitive deficit and improves hippocampal synaptic plasticity in adult rat with neonatal maternal separation [J ] . Evid Based Complement Alternat Med , 2018 , 2018 : 2468105 .

Spence JD . Secondary stroke prevention [J ] . Nat Rev Neurol , 2010 , 6 ( 9 ): 477 - 486 .

Zhang C , Wen Y , Fan XN , et al . Therapeutic effects of different durations of acupuncture on rats with middle cerebral artery occlusion [J ] . Neural Regen Res , 2015 , 10 ( 1 ): 159 - 164 .

Kim YR , Kim HN , Ahn SM , et al . Electroacupuncture promotes post-stroke functional recovery via enhancing endogenous neurogenesis in mouse focal cerebral ischemia [J ] . PLoS One , 2014 , 9 ( 2 ): e90000 .

Cherian K , Schatzberg AF , Keller J . HPA axis in psychotic major depression and schizophrenia spectrum disorders: cortisol, clinical symptomatology, and cognition [J ] . Schizophr Res , 2019 , 213 : 72 - 79 .

Yang Y , Yu HJ , Babygirija R , et al . Electroacupuncture attenuates chronic stress responses via up-regulated central NPY and GABA A receptors in rats [J ] . Front Neurosci , 2020 , 14 : 629003 .

Le JJ , Yi T , Qi L , et al . Electroacupuncture regulate hypothalamic-pituitary-adrenal axis and enhance hippocampal serotonin system in a rat model of depression [J ] . Neurosci Lett , 2016 , 615 : 66 - 71 .

Samuels BA , Mendez-David I , Faye C , et al . Serotonin 1A and serotonin 4 receptors: essential mediators of the neurogenic and behavioral actions of antidepressants [J ] . Neuroscientist , 2016 , 22 ( 1 ): 26 - 45 .

丁宁 , 李瑞 , 田环环 . 针刺与艾灸对慢性不可预见性温和应激抑郁大鼠前额皮质5-羟色胺系统的影响 [J ] . 针刺研究 , 2016 , 41 ( 1 ): 45 - 50 .

Lee GJ , Yin CS , Choi SK , et al . Acupuncture attenuates extracellular glutamate level in global ischemia model of rat [J ] . Neurol Res , 2010 , 32 ( Suppl 1 ): 79 - 83 .

Collins SM , Surette M , Bercik P . The interplay between the intestinal microbiota and the brain [J ] . Nat Rev Microbiol , 2012 , 10 ( 11 ): 735 - 742 .

廖冬梅 , 庞芳 , 杨云昊 , 等 . 基于肠道菌群探讨电针对APP/PS1小鼠认知能力的改善机制 [J ] . 中国病理生理杂志 , 2021 , 37 ( 10 ): 1774 - 1783 .

Jang JH , Yeom MJ , Ahn S , et al . Acupuncture inhibits neuroinflammation and gut microbial dysbiosis in a mouse model of Parkinson's disease [J ] . Brain Behav Immun , 2020 , 89 : 641 - 655 .

杨文丹 , 郭婉清 , 钱长晖 , 等 . 早期电针干预对SAMP8小鼠学习记忆能力和海马磷酸化Tau蛋白水平的影响 [J ] . 中国针灸 , 2020 , 40 ( 1 ): 68 - 74 .

魏歆然 , 魏高文 , 郑雪娜 , 等 . 不同经穴组合针刺对失眠大鼠下丘脑生物钟基因Clock和Bmal 1表达的影响 [J ] . 针刺研究 , 2017 , 42 ( 5 ): 429 - 433 .

罗云 , 武平 , 余泽芸 , 等 . 功能近红外光谱技术在针灸治疗脑病中的应用现状 [J ] . 中华中医药杂志 , 2021 , 36 ( 5 ): 2874 - 2877 .

Takamoto K , Hori E , Urakawa S , et al . Cerebral hemodynamic responses induced by specific acupuncture sensations during needling at trigger points: a near-infrared spectroscopic study [J ] . Brain Topogr , 2010 , 23 ( 3 ): 279 - 291 .

Chen JR , Li GL , Zhang GF , et al . Brain areas involved in acupuncture needling sensation of de Qi: a single-photon emission computed tomography (SPECT) study [J ] . Acupunct Med , 2012 , 30 ( 4 ): 316 - 323 .

Deng DM , Liao H , Duan GX , et al . Modulation of the default mode network in first-episode, drug-Naïve major depressive disorder via acupuncture at Baihui (GV20) acupoint [J ] . Front Hum Neurosci , 2016 , 10 : 230 .

Zheng WM , Su ZZ , Liu XY , et al . Modulation of functional activity and connectivity by acupuncture in patients with Alzheimer disease as measured by resting-state fMRI [J ] . PLoS One , 2018 , 13 ( 5 ): e0196933 .

Zhang JH , Li ZH , Li ZX , et al . Progress of acupuncture therapy in diseases based on magnetic resonance image studies: a literature review [J ] . Front Hum Neurosci , 2021 , 15 : 694919 .

Yin T , Ma PH , Tian ZL , et al . Machine learning in neuroimaging: a new approach to understand acupuncture for neuroplasticity [J ] . Neural Plast , 2020 , 2020 : 8871712 .

Zhang ZJ , Man SC , Yam LL , et al . Electroacupuncture trigeminal nerve stimulation plus body acupuncture for chemotherapy-induced cognitive impairment in breast cancer patients: an assessor-participant blinded, randomized controlled trial [J ] . Brain Behav Immun , 2020 , 88 : 88 - 96 .

Zhang ZJ , Zhao H , Jin GX , et al . Assessor- and participant-blinded, randomized controlled trial of dense cranial electroacupuncture stimulation plus body acupuncture for neuropsychiatric sequelae of stroke [J ] . Psychiatry Clin Neurosci , 2020 , 74 ( 3 ): 183 - 190 .

荣培晶 , 张悦 , 李少源 , 等 . 经皮耳穴迷走神经刺激治疗脑及相关疾病的现状与展望 [J ] . 世界科学技术-中医药现代化 , 2019 , 21 ( 9 ): 1799 - 1804 .

Yang SC , Qin ZS , Yang XJ , et al . Transcutaneous electrical cranial-auricular acupoint stimulation vs. escitalopram for patients with mild-to-moderate depression (TECAS): study design for a randomized controlled, non-inferiority trial [J ] . Front Psychiatry , 2022 , 13 : 829932 .

Feng B , Zhang Y , Luo LY , et al . Transcutaneous electrical acupoint stimulation for post-traumatic stress disorder: assessor-blinded, randomized controlled study [J ] . Psychiatry Clin Neurosci , 2019 , 73 ( 4 ): 179 - 186 .

Zhang R , Jia MX , Zhang JS , et al . Transcutaneous electrical acupoint stimulation in children with autism and its impact on plasma levels of arginine-vasopressin and oxytocin: a prospective single-blinded controlled study [J ] . Res Dev Disabil , 2012 , 33 ( 4 ): 1136 - 1146 .

Zhang HF , Li HX , Dai YC , et al . Electroacupuncture improves the social interaction behavior of rats [J ] . Physiol Behav , 2015 , 151 : 485 - 493 .

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