Acupoint thread-embedding for children with tic disorders of spleen deficiency and liver hyperactivity and its effect on serum level of NSE

JIN Yu-jing; GE Guo-lan

doi:10.13703/j.0255-2930.20230129-k0004

您当前的位置：

首页 >

文章列表页 >

Acupoint thread-embedding for children with tic disorders of spleen deficiency and liver hyperactivity and its effect on serum level of NSE

Clinical Research | 更新时间：2024-06-03

- Acupoint thread-embedding for children with tic disorders of spleen deficiency and liver hyperactivity and its effect on serum level of NSE
- Chinese Acupuncture & Moxibustion Vol. 43, Issue 11, Pages: 1261-1265(2023)
- 作者机构：
  
  河南省儿童医院郑州儿童医院中医科，郑州 450046
- 作者简介：
- 基金信息：
- DOI：10.13703/j.0255-2930.20230129-k0004
  CLC： R 246.4
- Received：29 January 2023，
  
  Online First：08 September 2023，
  
  Published：12 November 2023
- 稿件说明：
移动端阅览
金玉晶,葛国岚.穴位埋线治疗儿童脾虚肝旺型抽动障碍的临床疗效及对血清NSE水平的影响[J].中国针灸,2023,43(11):1261-1265.

JIN Yu-jing,GE Guo-lan.Acupoint thread-embedding for children with tic disorders of spleen deficiency and liver hyperactivity and its effect on serum level of NSE[J].Chinese Acupuncture & Moxibustion,2023,43(11):1261-1265.
金玉晶,葛国岚.穴位埋线治疗儿童脾虚肝旺型抽动障碍的临床疗效及对血清NSE水平的影响[J].中国针灸,2023,43(11):1261-1265. DOI： 10.13703/j.0255-2930.20230129-k0004.

JIN Yu-jing,GE Guo-lan.Acupoint thread-embedding for children with tic disorders of spleen deficiency and liver hyperactivity and its effect on serum level of NSE[J].Chinese Acupuncture & Moxibustion,2023,43(11):1261-1265. DOI： 10.13703/j.0255-2930.20230129-k0004.

摘要

目的

观察穴位埋线治疗儿童脾虚肝旺型抽动障碍（TD）的临床疗效及对患儿血清神经元特异性烯醇化酶（NSE）水平的影响。

方法

将68例脾虚肝旺型抽动障碍患儿随机分为观察组（34例，脱落1例）和对照组（34例，脱落3例、剔除1例）。观察组采用穴位埋线治疗，穴取百会及双侧合谷、太冲、脾俞、肝俞、曲池、足三里等，每4周治疗1次；对照组口服盐酸硫必利片治疗，每日2次。两组均治疗12周。比较两组患儿治疗前后耶鲁综合抽动严重程度量表（YGTSS）评分、血清NSE水平，并评定临床疗效。

结果

治疗后，除对照组YGTSS发声抽动评分外，两组患儿YGTSS各项评分及总分、血清NSE水平均较治疗前降低（

0.05），观察组患儿YGTSS各项评分及总分、血清NSE水平均低于对照组（

0.05）。观察组总有效率为87.9%（29/33），高于对照组的76.7%（23/30，

0.05）。

结论

穴位埋线治疗脾虚肝旺型TD具有较好的临床疗效，能降低患儿YGTSS评分及血清NSE水平。

Abstract

Objective

To observe the clinical efficacy of acupoint thread-embedding for children with tic disorders of spleen deficiency and liver hyperactivity and its effect on serum level of neuron-specific enolase (NSE).

Methods

A total of 68 children with tic disorders of spleen deficiency and liver hyperactivity were randomized into an observation group (34 cases

1 case dropped out) and a control group (34 cases

3 cases dropped out，1 case was eliminated). In the observation group

acupoint thread-embedding was applied at Baihui (GV 20) and bilateral Hegu (LI 4)

Taichong (LR 3)

Pishu (BL 20)

Ganshu (BL 18)

Quchi (LI 11)

Zusanli (ST 36)

etc.

once every 4 weeks. In the control group

tiapride hydrochloride tablet was given orally，twice a day. Both groups were treated for 12 weeks. Before and after treatment，the Yale global tic severity scale (YGTSS) score and serum level of NSE were observed in the two groups，and the clinical efficacy was evaluated.

Results

After treatment，except for vocal tic score of YGTSS in the control group，the each-item scores and total scores of YGTSS and serum levels of NSE in the two groups were decreased compared with those before treatment (

0.05); the each-item scores and total score of YGTSS and serum level of NSE in the observation group were lower than those in the control group (

0.05). The total effective rate in the observation group was 87.9% (29/33)

which was higher than 76.7% (23/30) in the control group (

0.05).

Conclusion

Acupoint thread-embedding has a good effect in the treatment of children with tic disorders of spleen deficiency and liver hyperactivity

could reduce the YGTSS score and serum level of NSE.

关键词

Keywords

references

Liu ZS , Cui YH , Sun D , et al . Current status, diagnosis, and treatment recommendation for tic disorders in China [J ] . Front Psychiatry , 2020 , 11 : 774 .

姜妍琳 , 张蔷 , 翟睿 , 等 . 中国儿童抽动障碍患病率及危险因素系统评价 [J ] . 中国儿童保健杂志 , 2023 , 31 ( 6 ): 661 - 667 .

沈玥赤 , 苏堂枫 , 肖沛 , 等 . 抽动障碍儿童心理行为问题及相关因素研究 [J ] . 中国学校卫生 , 2022 , 43 ( 10 ): 1535 - 1538 .

Jiang JL , Chen MX , Huang HF , et al . The aetiology of tourette syndrome and chronic tic disorder in children and adolescents: a comprehensive systematic review of case-control studies [J ] . Brain Sci , 2022 , 12 ( 9 ): 1202 .

王紫玄 , 张雨婷 , 沈雪薇 , 等 . 论儿童抽动障碍与肠道菌群的相关性 [J ] . 中医临床研究 , 2022 , 14 ( 23 ): 130 - 131 .

杨艺 , 陈全景 , 张斌强 . 微量元素与儿童抽动障碍关系的研究进展 [J ] . 广西医学 , 2022 , 44 ( 2 ): 226 - 228,236 .

夏梦琴 , 李玲 . 儿童抽动障碍的病因学研究进展 [J ] . 国际儿科学杂志 , 2022 , 49 ( 7 ): 453 - 456 .

Augustine F , Singer HS . Merging the pathophysiology and pharmacotherapy of tics [J ] . Tremor Other Hyperkinet Mov , 2018 , 8 : 595 .

辛莹莹 , 孙丹 , 刘智胜 . Tourette综合征及其他抽动障碍心理干预的欧洲临床指南(2021版)解读 [J ] . 中华实用儿科临床杂志 , 2022 , 37 ( 8 ): 596 - 600 .

卢青 , 孙丹 , 刘智胜 . 中国抽动障碍诊断和治疗专家共识解读 [J ] . 中华实用儿科临床杂志 , 2021 , 36 ( 9 ): 647 - 653 .

中华医学会儿科学分会神经学组 . 儿童抽动障碍诊断与治疗专家共识(2017实用版) [J ] . 中华实用儿科临床杂志 , 2017 , 32 ( 15 ): 1137 - 1140 .

Black KJ , Kim S , Yang NY , et al . Course of tic disorders over the lifespan [J ] . Curr Dev Disord Rep , 2021 , 8 ( 2 ): 121 - 132 .

李建荣 , 李显 , 孙明月 , 等 . 针灸治疗儿童抽动障碍的网状Meta分析 [J ] . 世界中西医结合杂志 , 2022 , 17 ( 6 ): 1079 - 1084 .

赵润芝 , 辛渊 , 王文妤 , 等 . 针刺治疗抽动障碍临床疗效的Meta分析 [J ] . 上海针灸杂志 , 2020 , 39 ( 2 ): 244 - 252 .

李敏 , 张新普 , 陈浩雄 , 等 . 穴位埋线法发展概述 [J ] . 河南中医 , 2023 , 43 ( 5 ): 800 - 803 .

李蔚沁 , 张子璐 , 秦卓 , 等 . 抽动障碍患儿T淋巴细胞亚群、血清神经元特异性烯醇化酶水平及意义 [J ] . 临床儿科杂志 , 2022 , 40 ( 6 ): 456 - 460 .

美国精神医学学会 . 精神障碍诊断与统计手册 [M ] . 5版 .张道龙译. 北京 : 北京大学出版社 , 2015 .

戎萍 , 马融 , 韩新民 , 等 . 中医儿科临床诊疗指南·抽动障碍(修订) [J ] . 中医儿科杂志 , 2019 , 15 ( 6 ): 1 - 6 .

马融 . 中医儿科学 [M ] . 4版 . 北京 : 中国中医药出版社 , 2016 .

Leckman JF , Riddle MA , Hardin MT , et al . The Yale global tic severity scale: initial testing of a clinician-rated scale of tic severity [J ] . J Am Acad Child Adolesc Psychiatry , 1989 , 28 ( 4 ): 566 - 573 .

胡思源 . 抽动障碍中药临床试验设计与评价技术指南 [J ] . 药物评价研究 , 2021 , 44 ( 9 ): 1837 - 1842 .

王艳萍 , 井淼 , 华颖 , 等 . 双歧杆菌三联活菌散添加治疗儿童抽动障碍疗效及对血清兴奋性氨基酸水平影响 [J ] . 实用医学杂志 , 2022 , 38 ( 2 ): 212 - 216 .

李亮 , 韩斐 . 抽动障碍中医证候及证素分布规律的文献研究 [J ] . 四川中医 , 2020 , 38 ( 12 ): 217 - 220 .

关玲 , 左芳 , 宋琪 , 等 . 穴位埋线技术标准化研究——国家标准《针灸技术操作规范第10部分: 穴位埋线》的制定说明 [J ] . 中国针灸 , 2009 , 29 ( 5 ): 401 - 405 .

张娟 , 刘文龙 , 王真真 . 盐酸硫必利与可乐定透皮贴治疗抽动障碍临床疗效的比较研究 [J ] . 临床合理用药杂志 , 2019 , 12 ( 30 ): 77 - 78 .

Shaik AJ , Reddy K , Mohammed N , et al . Neuron specific enolase as a marker of seizure related neuronal injury [J ] . Neurochem Int , 2019 , 131 : 104509 .

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Clinical efficacy and cost-effectiveness evaluation of acupoint thread-embedding for knee osteoarthritis of early to middle stage

Acupoint thread-embedding therapy in treatment of postoperative complications of mixed hemorrhoids: a randomized controlled trial

Clinical observation on acupoint thread-embedding for overweight and obesity in young adults with phlegm-dampness constitution

Acupoint thread-embedding at fat layer for abdominal obesity: a randomized controlled trial

Different frequency of acupoint thread-embedding for overweight/obesity of spleen deficiency and dampness retention: a randomized controlled trial

Related Author

QIN Weixun

YANG Gaiqin

HOU Jun

YANG Kaiyang

ZHENG Wenchun

AO Wanyi

LI Pengchao

NIU Mingliao

Related Institution

Shaanxi University of CM

Eleventh Department of Encephalopathy, Xi′an TCM Hospital of Encephalopathy

Department of Acupuncture and Moxibustion, Shaanxi Provincial Hospital of TCM

Teaching and Research Office of Surgery of TCM, Henan Provincial Hospital of TCM/Second Affiliated Hospital of Henan University of CM

Anorectal Disease Diagnosis and Treatment Center, Henan Provincial Hospital of TCM/Second Affiliated Hospital of Henan University of CM

⁰