WANG Xu,FAN Zheng-cui,ZHANG Zhen,et al.Application of in vivo brain imaging technology in the basic research of acupuncture-moxibustion for encephalopathy[J].Chinese Acupuncture & Moxibustion,2023,43(12):1363-1369.
WANG Xu,FAN Zheng-cui,ZHANG Zhen,et al.Application of in vivo brain imaging technology in the basic research of acupuncture-moxibustion for encephalopathy[J].Chinese Acupuncture & Moxibustion,2023,43(12):1363-1369.DOI: 10.13703/j.0255-2930.20230614-k0002.
Application of in vivo brain imaging technology in the basic research of acupuncture-moxibustion for encephalopathy
Acupuncture-moxibustion is remarkably effective on encephalopathy
but its mechanism is unclear. With the continuous development of imaging technology
the in vivo brain imaging technology has been used increasingly in life science research and it also becomes a more effective tool for the basic research of acupuncture-moxibustion in treatment of encephalopathy. The paper summarizes the application of its technology in the basic research of acupuncture-moxibustion for encephalopathy and the characteristics of imaging
as well as the advantages and shortcomings. It is anticipated that the references may be provided for the basic research of acupuncture-moxibustion in treatment of encephalopathy and be conductive to the modernization of acupuncture-moxibustion.
Zhang JH , Li ZH , Li ZX , et al . Progress of acupuncture therapy in diseases based on magnetic resonance image studies: a literature review [J ] . Front Hum Neurosci , 2021 , 15 : 694919 .
Dana H , Sun Y , Mohar B , et al . High-performance calcium sensors for imaging activity in neuronal populations and microcompartments [J ] . Nat Methods , 2019 , 16 ( 7 ): 649 - 657 .
Yang WJ , Yuste R . In vivo imaging of neural activity [J ] . Nat Methods , 2017 , 14 ( 4 ): 349 - 359 .
Gao XY , Han S , Huang Q , et al . Calcium imaging in population of dorsal root ganglion neurons unravels novel mechanisms of visceral pain sensitization and referred somatic hypersensitivity [J ] . Pain , 2021 , 162 ( 4 ): 1068 - 1081 .
Chen C , Zhang JH , Sun LL , et al . Long-term imaging of dorsal root Ganglia in awake behaving mice [J ] . Nat Commun , 2019 , 10 ( 1 ): 3087 .
Gong P , Zhang SS , Ren L , et al . Electroacupuncture of the trigeminal nerve causes N-methyl-D-aspartate receptors to mediate blood-brain barrier opening and induces neuronal excitatory changes [J ] . Front Cell Neurosci , 2022 , 16 : 1020644 .
Li S , Liu Y , Zhang N , et al . Perspective of calcium imaging technology applied to acupuncture research [J ] . Chin J Integr Med , 2023 . doi: 10.1007/s11655-023-3692-2 http://dx.doi.org/10.1007/s11655-023-3692-2 .
Koba W , Jelicks LA , Fine EJ . MicroPET/SPECT/CT imaging of small animal models of disease [J ] . Am J Pathol , 2013 , 182 ( 2 ): 319 - 324 .
Cao J , Tang YS , Li YJ , et al . Behavioral changes and hippocampus glucose metabolism in APP/PS1 transgenic mice via electro-acupuncture at governor vessel acupoints [J ] . Front Aging Neurosci , 2017 , 9 : 5 .
Cai MD , Lee JH , Yang EJ . Electroacupuncture attenuates cognition impairment via anti-neuroinflammation in an Alzheimer's disease animal model [J ] . J Neuroinflammation , 2019 , 16 ( 1 ): 264 .
Senarathna J , Rege A , Li N , et al . Laser speckle contrast imaging: theory, instrumentation and applications [J ] . IEEE Rev Biomed Eng , 2013 , 6 : 99 - 110 .
Briers D , Duncan DD , Hirst E , et al . Laser speckle contrast imaging: theoretical and practical limitations [J ] . J Biomed Opt , 2013 , 18 ( 6 ): 066018 .
Jiang YM , Lin YS , Tan YH , et al . Electroacupuncture ameliorates cerebrovascular impairment in Alzheimer's disease mice via melatonin signaling [J ] . CNS Neurosci Ther , 2023 , 29 ( 3 ): 917 - 931 .
Cui S , Yao SQ , Wu CX , et al . Electroacupuncture involved in motor cortex and hypoglossal neural control to improve voluntary swallowing of poststroke dysphagia mice [J ] . Neural Plast , 2020 , 2020 : 8857543 .
Hu S , Maslov K , Wang LV . Second-generation optical-resolution photoacoustic microscopy with improved sensitivity and speed [J ] . Opt Lett , 2011 , 36 ( 7 ): 1134 - 1136 .
Chen BZ , Yang JG , Wu D , et al . Photoacoustic imaging of cerebral hypoperfusion during acupuncture [J ] . Biomed Opt Express , 2015 , 6 ( 9 ): 3225 - 3234 .
Yang JG , Wu D , Tang Y , et al . Photoacoustic microscopy of electronic acupuncture (EA) effect in small animals [J ] . J Biophotonics , 2017 , 10 ( 2 ): 217 - 223 .
Scholkmann F , Kleiser S , Metz AJ , et al . A review on continuous wave functional near-infrared spectroscopy and imaging instrumentation and methodology [J ] . Neuroimage , 2014 , 85 ( Pt 1 ): 6 - 27 .
Takamoto K , Hori E , Urakawa S , et al . Cerebral hemodynamic responses induced by specific acupuncture sensations during needling at trigger points: a near-infrared spectroscopic study [J ] . Brain Topogr , 2010 , 23 ( 3 ): 279 - 291 .
Yujuan YE , Wei YT , Jia J , et al . Efficacy of needling Baihui (GV20), Neiguan (PC6), Shenmen (HT7) and Taichong (LR3) on cerebral cortical blood oxygen level in rats with insomnia [J ] . J Tradit Chin Med , 2023 , 43 ( 3 ): 523 - 532 .
Chen J , Li H , Zeng C , et al . Evaluation of the recovery outcome of poststroke cognitive impairment after cluster needling of scalp acupuncture therapy based on functional near-infrared spectroscopy [J ] . Brain Behav , 2020 , 10 ( 8 ): e01731 .
Ghafoor U , Lee JH , Hong KS , et al . Effects of acupuncture therapy on MCI patients using functional near-infrared spectroscopy [J ] . Front Aging Neurosci , 2019 , 11 : 237 .
Zhang TY , Zhang JQ , Huang JX , et al . Neural activation via acupuncture in patients with major depressive disorder: a functional near-infrared spectroscopy study [J ] . Front Psychiatry , 2021 , 12 : 669533 .
Liang SX , Lin YJ , Lin BB , et al . Resting-state functional magnetic resonance imaging analysis of brain functional activity in rats with ischemic stroke treated by electro-acupuncture [J ] . J Stroke Cerebrovasc Dis , 2017 , 26 ( 9 ): 1953 - 1959 .
Wang ZX , Fan XW , Chen KY , et al . Effects of three kinds of head acupuncture therapies on regulation of brain microenvironment and rehabilitation of nerve function in rats with cerebral palsy [J ] . J Tradit Chin Med , 2021 , 41 ( 2 ): 276 - 283 .
Chiu JH , Chung MS , Cheng HC , et al . Different central manifestations in response to electroacupuncture at analgesic and nonanalgesic acupoints in rats: a manganese-enhanced functional magnetic resonance imaging study [J ] . Can J Vet Res , 2003 , 67 ( 2 ): 94 - 101 .
Guo CL , Wang AM , Cheng HP , et al . New imaging instrument in animal models: two-photon miniature microscope and large field of view miniature microscope for freely behaving animals [J ] . J Neurochem , 2023 , 164 ( 3 ): 270 - 283 .
Zong WJ , Wu RL , Li ML , et al . Fast high-resolution miniature two-photon microscopy for brain imaging in freely behaving mice [J ] . Nat Methods , 2017 , 14 ( 7 ): 713 - 719 .
Zong WJ , Wu RL , Chen SY , et al . Miniature two-photon microscopy for enlarged field-of-view, multi-plane and long-term brain imaging [J ] . Nat Methods , 2021 , 18 ( 1 ): 46 - 49 .
Chang XY , Chen K , Cheng T , et al . In vivo neuronal and astrocytic activation in somatosensory cortex by acupuncture stimuli [J ] . Neural Regen Res , 2022 , 17 ( 11 ): 2526 - 2529 .
Ding N , Liu XX , Chen NB , et al . Lack of association between acupoint sensitization and microcirculatory structural changes in a mouse model of knee osteoarthritis: a pilot study [J ] . J Biophotonics , 2019 , 12 ( 6 ): e201800458 .
Kimura K , Ryujin T , Uno M , et al . The effect of electroacupuncture with different frequencies on muscle oxygenation in humans [J ] . Evid Based Complement Alternat Med , 2015 , 2015 : 620785 .
Brief summary on acupuncture-moxibustion education in ancient China and thinking on disciplinary innovation
Development of acupuncture-moxibustion discipline——the transition from acupuncture-moxibustion to acupuncture-moxibustion medicine
Exploration of clinical diagnosis and treatment thinking of acupuncture-moxibustion based on the "meridian and zang-fu correlation" theory
Historical narrative of "relationship between body surface and target organs": the spiritual connection between Qibo and Galenus
Effect of electroacupuncture combined with suspension exercise therapy on lower limb motor function in elderly patients with post-stroke spastic hemiplegia
Related Author
WANG Xu
WANG Kunxiu
ZHU Xiaoling
LI Siyu
QU Hui
YANG Yueyue
LI Zengyan
FU Wenbin
Related Institution
Department of Acupuncture and Moxibustion, Second Affiliated Hospital of Guangzhou University of CM
Second Clinical College, Guangzhou University of CM
Clinical Medical College of Acupuncture-Moxibustion and Rehabilitation, Guangzhou University of CM
Third Clinical Hospital of Changchun University of CM
School of Acupuncture-Moxibustion and Tuina, Changchun University of CM