Introduction to the Meta-analysis method of functional magnetic resonance imaging research and the exploration of its application in the field of acupuncture

GE Wenyi; LIU Wei; FAN Xiaonong; LI Yibing; JIA Hongbo; LEI Kangchen; LI Songjiao; CHANG Yinghui

doi:10.13703/j.0255-2930.20230627-k0003

您当前的位置：

首页 >

文章列表页 >

Introduction to the Meta-analysis method of functional magnetic resonance imaging research and the exploration of its application in the field of acupuncture

Imaging in clinical and basic research | 更新时间：2024-06-03

- Introduction to the Meta-analysis method of functional magnetic resonance imaging research and the exploration of its application in the field of acupuncture
- Chinese Acupuncture & Moxibustion Vol. 44, Issue 1, Pages: 25-33(2024)
- 作者机构：
  
  1.天津中医药大学第一附属医院，天津300193
  2.国家中医针灸临床医学研究中心，天津300193
  3.天津市针灸研究所，天津300193
  4.天津市针灸学重点实验室，天津300193
  5.国家中医药管理局针刺量效关系实验室（三级），天津300193
- 作者简介：
- 基金信息：
- DOI：10.13703/j.0255-2930.20230627-k0003
  CLC：
- Received：27 June 2023，
  
  Online First：24 November 2023，
  
  Published：12 January 2024
- 稿件说明：
移动端阅览
葛文逸,刘巍,樊小农等.功能磁共振研究元分析方法介绍及其在针刺领域的应用探析[J].中国针灸,2024,44(01):25-33.

GE Wenyi,LIU Wei,FAN Xiaonong,et al.Introduction to the Meta-analysis method of functional magnetic resonance imaging research and the exploration of its application in the field of acupuncture[J].Chinese Acupuncture & Moxibustion,2024,44(01):25-33.
葛文逸,刘巍,樊小农等.功能磁共振研究元分析方法介绍及其在针刺领域的应用探析[J].中国针灸,2024,44(01):25-33. DOI： 10.13703/j.0255-2930.20230627-k0003.

GE Wenyi,LIU Wei,FAN Xiaonong,et al.Introduction to the Meta-analysis method of functional magnetic resonance imaging research and the exploration of its application in the field of acupuncture[J].Chinese Acupuncture & Moxibustion,2024,44(01):25-33. DOI： 10.13703/j.0255-2930.20230627-k0003.

摘要

近年来针刺领域功能磁共振成像（fMRI）研究数量不断增加，但由于腧穴选择、针刺手法以及样本量等差异，致使研究间结果分散、针刺共性规律不明的问题越发凸显。笔者以针刺治疗中风后运动障碍（PSMD）相关fMRI研究为例，引出并介绍了整合相关研究结果、提取共性规律的fMRI元分析技术：基于图像的元分析（IBMA）和基于坐标的元分析（CBMA）。鉴于CBMA的可实施性更高，故重点说明了3种可用的CBMA方法，即激活似然估计（ALE）、核密度分析（KDA）和基于种子的

映射（SDM）；并以开展CBMA的注意事项、操作流程为切入点，对研究的fMRI类型、任务设计、分析方法以及开展fMRI元分析的整体思维考量过程进行了系统梳理，整理成图表，旨在帮助读者能够快速、方便、相对系统地对其中抽象复杂的理论和实战信息进行了解和理解，为其今后更深入地学习和应用起到抛砖引玉的作用。

Abstract

In recent years

the number of functional magnetic resonance imaging (fMRI) research in acupuncture grows increasingly. However

due to the differences in acupoint selection

acupuncture technique and sample size

the problems get more prominent in terms of the diverse results and the lack of common rules of acupuncture among researches. By taking the fMRI research for post-stroke motor dysfunction (PSMD) treated with acupuncture as the example

this paper introduces the fMRI Meta-analysis technology for integrating the relevant research results and extracting the common rules

namely image-based Meta-analysis (IBMA) and coordinate-based Meta-analysis (CBMA). Considering the higher feasibility of CBMA

three available CBMA methods are explained specially

including activation likelihood estimation (ALE)

kernel density analysis (KDA)

and seed-based

mapping (SDM). Focusing on the precautions and operation procedure of CBMA

the review is conducted systematically on the type of fMRI research

task design

analytical method

and the thinking

integrity of fMRI Meta-analysis

and the review findings are collated in charts. It aims to assist readers to understand the abstract and complex theories and practical information of this technology efficiently

conveniently and systematically

and hopes to provide the references for the future learning and the application.

关键词

Keywords

references

Kim SG , Ogawa S . Biophysical and physiological origins of blood oxygenation level-dependent fMRI signals [J ] . J Cereb Blood Flow Metab , 2012 , 32 ( 7 ): 1188 - 1206 .

邓沁丽 , 陈俊 . 基于坐标的脑成像元分析方法: 激活似然性评估 [J ] . 心理科学 , 2015 , 38 ( 1 ): 216 - 220 .

Jauhar S , Fortea L , Solanes A , et al . Brain activations associated with anticipation and delivery of monetary reward: a systematic review and meta-analysis of fMRI studies [J ] . PLoS One , 2021 , 16 ( 8 ): e0255292 .

Lv QY , Xu GX , Pan YX , et al . Effect of acupuncture on neuroplasticity of stroke patients with motor dysfunction: a meta-analysis of fMRI studies [J ] . Neural Plast , 2021 , 2021 : 8841720 .

Ha GD , Tian ZL , Chen JY , et al . Coordinate-based (ALE) meta-analysis of acupuncture for musculoskeletal pain [J ] . Front Neurosci , 2022 , 16 : 906875 .

Salimi-Khorshidi G , Smith SM , Keltner JR , et al . Meta-analysis of neuroimaging data: a comparison of image-based and coordinate-based pooling of studies [J ] . Neuroimage , 2009 , 45 ( 3 ): 810 - 823 .

Collins DL , Neelin P , Peters TM , et al . Automatic 3D intersubject registration of MR volumetric data in standardized Talairach space [J ] . J Comput Assist Tomogr , 1994 , 18 ( 2 ): 192 - 205 .

Talairach J , Tournoux PA , Rayport M . Co-planar Stereotaxic Atlas of the Human Brain 3-d Imensional Proportional System : an Approach to Cerebral Imaging [M ] . Stuttgart : Thieme , 1988 .

付彩红 , 宁艳哲 , 张勇 , 等 . 针刺阳陵泉对中风偏瘫病人局部一致性影响的静息态fMRI研究 [J ] . 中西医结合心脑血管病杂志 , 2019 , 17 ( 11 ): 1623 - 1629 .

周钰 , 贾小飞 , 刘佳妮 , 等 . 低频振幅分析针刺脑卒中痉挛患者拮抗肌的静息态脑功能MRI研究 [J ] . 宁夏医学杂志 , 2020 , 42 ( 7 ): 601 - 604 .

Wager TD , Lindquist MA , Nichols TE , et al . Evaluating the consistency and specificity of neuroimaging data using meta-analysis [J ] . Neuroimage , 2009 , 45 ( 1 Suppl ): S210 - S221 .

Wager TD , Phan KL , Liberzon I , et al . Valence, gender, and lateralization of functional brain anatomy in emotion: a meta-analysis of findings from neuroimaging [J ] . Neuroimage , 2003 , 19 ( 3 ): 513 - 531 .

Wager TD , Lindquist M , Kaplan L . Meta-analysis of functional neuroimaging data: current and future directions [J ] . Soc Cogn Affect Neurosci , 2007 , 2 ( 2 ): 150 - 158 .

Turkeltaub PE , Eden GF , Jones KM , et al . Meta-analysis of the functional neuroanatomy of single-word reading: method and validation [J ] . Neuroimage , 2002 , 16 ( 3 Pt 1 ): 765 - 780 .

Eickhoff SB , Nichols TE , Laird AR , et al . Behavior, sensitivity, and power of activation likelihood estimation characterized by massive empirical simulation [J ] . Neuroimage , 2016 , 137 : 70 - 85 .

Radua J , Mataix-Cols D . Voxel-wise meta-analysis of grey matter changes in obsessive-compulsive disorder [J ] . Br J Psychiatry , 2009 , 195 ( 5 ): 393 - 402 .

Radua J , Rubia K , Canales-Rodríguez EJ , et al . Anisotropic kernels for coordinate-based meta-analyses of neuroimaging studies [J ] . Front Psychiatry , 2014 , 5 : 13 .

Albajes-Eizagirre A , Solanes A , Vieta E , et al . Voxel-based meta-analysis via permutation of subject images (PSI): theory and implementation for SDM [J ] . Neuroimage , 2019 , 186 : 174 - 184 .

Wager TD , Jonides J , Reading S . Neuroimaging studies of shifting attention: a meta-analysis [J ] . Neuroimage , 2004 , 22 ( 4 ): 1679 - 1693 .

Eickhoff SB , Laird AR , Grefkes C , et al . Coordinate-based activation likelihood estimation meta-analysis of neuroimaging data: a random-effects approach based on empirical estimates of spatial uncertainty [J ] . Hum Brain Mapp , 2009 , 30 ( 9 ): 2907 - 2926 .

Radua J , Mataix-Cols D , Phillips ML , et al . A new meta-analytic method for neuroimaging studies that combines reported peak coordinates and statistical parametric maps [J ] . Eur Psychiatry , 2012 , 27 ( 8 ): 605 - 611 .

Albajes-Eizagirre A , Solanes A , Radua J . Meta-analysis of non-statistically significant unreported effects [J ] . Stat Methods Med Res , 2019 , 28 ( 12 ): 3741 - 3754 .

Acar F , Seurinck R , Eickhoff SB , et al . Assessing robustness against potential publication bias in activation likelihood estimation (ALE) meta-analyses for fMRI [J ] . PLoS One , 2018 , 13 ( 11 ): e0208177 .

Ferreira LK , Busatto GF . Heterogeneity of coordinate-based meta-analyses of neuroimaging data: an example from studies in OCD [J ] . Br J Psychiatry , 2010 , 197 ( 1 ): 76 - 77 .

BrainMap Discussions . Re:vs SDM,did the ALE method also has some advantages? [EB/OL ] .( 2013-07-16 )[ 2023-06-27 ] . http://brainmap.org/forum/viewtopic.php?f=3&t=403&sid=b5fcfcf928e4c32b0a31a081dc742727 http://brainmap.org/forum/viewtopic.php?f=3&t=403&sid=b5fcfcf928e4c32b0a31a081dc742727 .

Wen JJ , Gao YY , Li MT , et al . Regional abnormalities of spontaneous brain activity in migraine: a coordinate-based meta-analysis [J ] . J Neurosci Res , 2023 , 101 ( 8 ): 1205 - 1223 .

方继良 , 王小玲 . 脑功能磁共振成像技术简介及针刺研究应用(一) [J ] . 中国中西医结合影像学杂志 , 2012 , 10 ( 1 ): 94 - 96 .

尹涛 , 何昭璇 , 马培宏 , 等 . 针刺功能磁共振成像研究任务设计方法述评 [J ] . 中华中医药学刊 , 2019 , 37 ( 7 ): 1657 - 1660 .

郑禹 , 黄泳 , 赖新生 , 等 . 缺血性中风患者外关穴巨刺fMRI脑功能成像研究 [J ] . 辽宁中医药大学学报 , 2012 , 14 ( 3 ): 29 - 31 .

肖慧玲 , 陈俊琦 , 曲姗姗 , 等 . 缺血性中风患者健侧外关穴浅刺fMRI脑功能成像研究 [J ] . 辽宁中医杂志 , 2012 , 39 ( 10 ): 2044 - 2046 .

陈俊琦 . 针刺缺血性脑卒中病人外关穴fMRI脑功能成像研究 [D ] . 广州 : 南方医科大学 , 2013 .

劳祥婷 . 针刺督脉及被动运动对脑卒中后肢体痉挛的脑功能即时效应的影响 [D ] . 成都 : 成都中医药大学 , 2014 .

涂永梅 . 通督解痉法配合牵伸康复技术对梗塞后肌痉挛患者的脑功能变化研究 [D ] . 成都 : 成都中医药大学 , 2015 .

王苇 , 赵义 , 周龙江 , 等 . 脑梗死偏瘫患者针刺下神经作用机制的血氧水平依赖性功能磁共振成像及弥散张量成像研究 [J ] . 中华物理医学与康复杂志 , 2015 , 37 ( 9 ): 662 - 667 .

蔡雪 . 牵伸疗法结合头部电针对脑卒中后肌痉挛患者脑功能即时效应的观察 [D ] . 成都 : 成都中医药大学 , 2016 .

张贵锋 , 黄泳 , 唐纯志 , 等 . 基于功能性磁共振成像在正常与病理状态下针刺外关穴时脑负激活的脑区定位研究 [J ] . 中国全科医学 , 2017 , 20 ( 9 ): 1098 - 1103 .

马荣荣 . 针刺阳陵泉穴对卒中偏瘫患者被动运动时基于Granger因果的fMRI研究 [D ] . 北京 : 北京中医药大学 , 2013 .

司卫军 , 张华 , 王朋 , 等 . 针刺阳陵泉对脑梗死患者被动运动的即刻效应观察 [J ] . 中国针灸 , 2013 , 33 ( 2 ): 131 - 136 .

Zang YF , Jiang TZ , Lu YL , et al . Regional homogeneity approach to fMRI data analysis [J ] . NeuroImage , 2004 , 22 ( 1 ): 394 - 400 .

Zang YF , He Y , Zhu CZ , et al . Altered baseline brain activity in children with ADHD revealed by resting-state functional MRI [J ] . Brain Dev , 2007 , 29 ( 2 ): 83 - 91 .

高璇 , 鲁海 , 高霄英 , 等 . 针刺临床研究中常用的Rs-fMRI分析方法：10年概况 [J ] . 分子影像学杂志 , 2020 , 43 ( 4 ): 568 - 571 .

陈富琴 , 张俊然 , 蒋小梅 , 等 . 有效连接分析在脑功能磁共振数据中的发展和应用 [J ] . 航天医学与医学工程 , 2016 , 29 ( 4 ): 307 - 312 .

Liu JK , Li Y , Yang X , et al . Regional spontaneous neural activity alterations in type 2 diabetes mellitus: a meta-analysis of resting-state functional MRI studies [J ] . Front Aging Neurosci , 2021 , 13 : 678359 .

Wang J , Zhang JR , Zang YF , et al . Consistent decreased activity in the putamen in Parkinson's disease: a meta-analysis and an independent validation of resting-state fMRI [J ] . Gigascience , 2018 , 7 ( 6 ): giy071 .

Müller VI , Cieslik EC , Laird AR , et al . Ten simple rules for neuroimaging meta-analysis [J ] . Neurosci Biobehav Rev , 2018 , 84 : 151 - 161 .

Zang YF , Zuo XN , Milham M , et al . Toward a meta-analytic synthesis of the resting-state fMRI literature for clinical populations [J ] . Biomed Res Int , 2015 , 2015 : 435265 .

Albajes-Eizagirre A , Solanes A , Fullana MA , et al . Meta-analysis of voxel-based neuroimaging studies using seed-based d mapping with permutation of subject images (SDM-PSI) [J ] . J Vis Exp , 2019 ( 153 ). doi: 10.3791/59841 http://dx.doi.org/10.3791/59841 .

Eickhoff SB , Bzdok D , Laird AR , et al . Activation likelihood estimation meta-analysis revisited [J ] . Neuroimage , 2012 , 59 ( 3 ): 2349 - 2361 .

张洪英 , 吴晶涛 . 脑功能磁共振信号分析技术及应用研究进展 [J ] . 东南大学学报(医学版) , 2015 , 34 ( 2 ): 320 - 324 .

Calhoun VD , Adali T , Pearlson GD , et al . A method for making group inferences from functional MRI data using independent component analysis [J ] . Hum Brain Mapp , 2001 , 14 ( 3 ): 140 - 151 .

曾晓清 . 针刺对缺血性中风患者中枢活性的影响—局部一致性的分析 [D ] . 成都 : 成都中医药大学 , 2013 .

谢西梅 , 武平 , 黄琳娜 , 等 . 针刺治疗缺血性中风患者ReHo的静息态功能磁共振研究 [J ] . 辽宁中医杂志 , 2013 , 40 ( 7 ): 1287 - 1291 .

周玉梅 . 针刺对缺血性中风患者脑功能影响的研究——局部一致性分析 [D ] . 成都 : 成都中医药大学 , 2015 .

陈致宏 . “升阳通督”针法对缺血性中风患者的疗效观察及对fMRI影响的研究 [D ] . 昆明 : 云南中医学院 , 2016 .

陈纳纳 . 针刺组穴对脑梗死后偏瘫患者脑功能观察研究 [D ] . 广州 : 广州中医药大学 , 2017 .

陈淑琪 . 基于ReHo观察巨刺法对缺血性中风偏瘫患者脑功能影响研究 [D ] . 广州 : 广州中医药大学 , 2019 .

阳运秋 , 唐纯志 , 崔韶阳 , 等 . 靳三针结合镜像疗法对脑卒中上肢功能障碍患者脑功能效应的影响 [J ] . 中医杂志 , 2019 , 60 ( 8 ): 675 - 679 .

An L , Cao QJ , Sui MQ , et al . Local synchronization and amplitude of the fluctuation of spontaneous brain activity in attention-deficit/hyperactivity disorder: a resting-state fMRI study [J ] . Neurosci Bull , 2013 , 29 ( 5 ): 603 - 613 .

Premi E , Cauda F , Gasparotti R , et al . Multimodal FMRI resting-state functional connectivity in granulin mutations: the case of fronto-parietal dementia [J ] . PLoS One , 2014 , 9 ( 9 ): e106500 .

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Exploring the regulatory effect of acupuncture for Ningshen Tongqiao on the functional connectivity between the anterior cingulate cortex and the whole brain in the patients with subjective tinnitus based on fMRI

Research status and prospects of electroencephalogram characteristics in acupuncture for cognitive dysfunction

Research progress on the regulatory mechanisms of inflammatory signaling pathways in acupuncture treatment for ischemic stroke

Clinical experience in treatment of dysmyotonia with the combination of acupuncture and herbal medicine based on the theory of "kidney deficiency, impairment of governor vessel and meridian damage by toxin"

Effect of moxibustion-induced deqi on hippocampal autophagy function in APPswe/PSEN1dE9 transgenic Alzheimer′s disease mice

Related Author

ZHANG Yating

ZHA Bixiang

SHI Haiping

FAN Yinqiu

ZHENG Yunzi

RONG Zhihao

YANG Jun

WANG Xiaome

Related Institution

First School of Clinical Medicine of Anhui University of CM

First Affiliated Hospital of Anhui University of CM

Department of Acupuncture and Moxibustion, First Teaching Hospital of Tianjin University of TCM

National Clinical Research Center for Chinese Medicine

Graduate School, Tianjin University of TCM

⁰