Acupotomy combined with metformin hydrochloride tablet for type 2 diabetes mellitus and its effect on serum inflammatory factors

ZHU Tao; JI Laixi; GAO Zhen; REN Jia; JI Yufang; MIAO Jinling

doi:10.13703/j.0255-2930.20230705-k0002

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Acupotomy combined with metformin hydrochloride tablet for type 2 diabetes mellitus and its effect on serum inflammatory factors

Clinical Research | 更新时间：2024-06-03

- Acupotomy combined with metformin hydrochloride tablet for type 2 diabetes mellitus and its effect on serum inflammatory factors
- Chinese Acupuncture & Moxibustion Vol. 44, Issue 3, Pages: 245-250(2024)
- 作者机构：
  
  1.成都中医药大学针灸推拿学院，四川成都 611137
  2.山西中医药大学第二临床学院
  3.山西省针灸医院针灸四科，太原 030006
- 作者简介：
- 基金信息：
- DOI：10.13703/j.0255-2930.20230705-k0002
  CLC：
- Received：05 July 2023，
  
  Online First：18 December 2023，
  
  Published：12 March 2024
- 稿件说明：
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朱涛,冀来喜,高珍,等.针刀联合盐酸二甲双胍片治疗2型糖尿病的临床疗效及对血清炎性因子含量的影响[J].中国针灸,2024,44(3):245-250.

ZHU Tao,JI Laixi,GAO Zhen,et al.Acupotomy combined with metformin hydrochloride tablet for type 2 diabetes mellitus and its effect on serum inflammatory factors[J].Chinese Acupuncture & Moxibustion,2024,44(03):245-250.
朱涛,冀来喜,高珍,等.针刀联合盐酸二甲双胍片治疗2型糖尿病的临床疗效及对血清炎性因子含量的影响[J].中国针灸,2024,44(3):245-250. DOI： 10.13703/j.0255-2930.20230705-k0002.

ZHU Tao,JI Laixi,GAO Zhen,et al.Acupotomy combined with metformin hydrochloride tablet for type 2 diabetes mellitus and its effect on serum inflammatory factors[J].Chinese Acupuncture & Moxibustion,2024,44(03):245-250. DOI： 10.13703/j.0255-2930.20230705-k0002.

摘要

目的

观察针刀联合盐酸二甲双胍片治疗2型糖尿病（T2DM）的临床疗效及对血清炎性因子含量的影响。

方法

将68例T2DM患者随机分为针刀组（34例，脱落2例）和西药组（34例，脱落2例）。西药组予盐酸二甲双胍片口服，每次0.5~1 g，每日2次，并根据血糖调整药物用量，连续治疗8周；针刀组在西药组基础上予针刀治疗，穴取双侧膈俞、胃脘下俞、肝俞，每周1次，连续治疗8周。观察两组患者治疗前后血糖［空腹血糖（FBG）、餐后2 h血糖（2 h PG）、糖化血红蛋白（HbA1c）］、中医证候积分、血脂［总胆固醇（TC）、三酰甘油（TG）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）］、胰岛素［空腹胰岛素（FINS）、餐后2 h胰岛素（2 h INS）］、C肽指标［空腹C肽（FC-P）、餐后2 h C肽（2 h C-P）］、盐酸二甲双胍片用量、糖尿病特异性生存质量量表（DSQL）评分，采用ELISA法检测血清肿瘤坏死因子（TNF）-α、白细胞介素（IL）-6、IL-17含量。

结果

治疗后，两组患者FBG、2 h PG、HbA1c、中医证候积分、TC、TG、LDL-C、FINS、2 h INS、FC-P、2 h C-P、DSQL评分及血清TNF-α、IL-6、IL-17含量均较治疗前降低（

0.01），HDL-C较治疗前升高（

0.01），针刀组盐酸二甲双胍片用量较治疗前减少（

0.01）；针刀组FBG、HbA1c、中医证候积分、TC、TG、LDL-C、FINS、2 h INS、FC-P、2 h C-P、盐酸二甲双胍片用量、DSQL评分及血清TNF-α含量低于西药组（

0.05）。

结论

针刀联合盐酸二甲双胍片能改善T2DM患者的血糖及临床症状，提高患者生活质量，其机制可能与调控炎性反应相关。

Abstract

Objective

To observe the clinical efficacy of acupotomy combined with metformin hydrochloride tablet for type 2 diabetes mellitus (T2DM) and its effect on serum levels of inflammatory factors.

Methods

A total of 68 patients with T2DM were randomized into an acupotomy group (34 cases

2 cases dropped out) and a western medication group (34 cases

2 cases dropped out). Metformin hydrochloride tablet was given orally in the western medication group

0.5-1 g each time

twice a day

for continuous 8 weeks. On the basis of the treatment in the western medication group

acupotomy was applied at bilateral Geshu (BL 17)

Weiwanxiashu (EX-B 3)

Ganshu (BL 18) in the acupotomy group

once a week for continuous 8 weeks. Before and after treatment

in the two groups

blood glucose (fasting blood glucose [FBG]

2-hour plasma glucose [2 h PG] and glycosylated hemoglobin [HbA1c])

TCM syndrome score

blood lipids (total cholesterol [TC]

triglyceride [TG]

low density lipoprotein cholesterol [LDL-C] and high density lipoprotein cholesterol [HDL-C])

insulin (fasting insulin [FINS] and 2-hour insulin [2 h INS])

C-peptide indexes (fasting C-peptide [FC-P] and 2-hour C-peptide [2 h C-P])

dosage of metformin hydrochloride tablet and diabetes specific quality of life (DSQL) score were observed

the serum levels of tumor necrosis factor (TNF)-α

interleukin (IL)-6 and IL-17 were measured by ELISA.

Results

After treatment

the FBG

2 h PG

HbA1c

TCM syndrome scores

LDL-C

FINS

2 h INS

FC-P

2 h C-P

DSQL scores as well as the serum levels of TNF-α

IL-6

IL-17 were decreased compared with those before treatment (

0.01)

HDL-C was increased compared with that before treatment (

0.01) in the two groups; the dosage of metformin hydrochloride tablet was decreased compared with that before treatment in the acupotomy group (

0.01). After treatment

in the acupotomy group

the FBG

HbA1c

TCM syndrome score

LDL-C

FINS

2 h INS

FC-P

2 h C-P

dosage of metformin hydrochloride tablet

DSQL score as well as the serum level of TNF-α were lower than those in the western medication group (

0.05).

Conclusion

Acupotomy combined with metformin hydrochloride tablet can improve the blood glucose

clinical symptoms and quality of life in patients with T2DM

its mechanism may be related to the regulation of inflammatory reaction.

关键词

Keywords

references

马越 , 孔祥婕 , 彭雯 , 等 . 中国糖尿病疾病负担现状及趋势 [J ] . 中国预防医学杂志 , 2023 , 24 ( 4 ): 281 - 286 .

中华人民共和国国家卫生健康委员会 . 成人糖尿病食养指南(2023年版) [J ] . 全科医学临床与教育 , 2023 , 21 ( 5 ): 388 - 391 .

李慧娟 . 双胍类降糖药物对于2型糖尿病治疗的临床疗效分析 [J ] . 智慧健康 , 2021 , 7 ( 31 ): 108 - 110 .

《中国老年2型糖尿病防治临床指南》编写组 . 中国老年2型糖尿病防治临床指南(2022年版) [J ] . 中国糖尿病杂志 , 2022 , 30 ( 1 ): 2 - 51 .

解鸿宇 , 袁爱红 , 杨骏 . 艾灸治疗2型糖尿病认知功能减退疗效观察 [J ] . 中国针灸 , 2020 , 40 ( 12 ): 1286 - 1290 .

李博 , 赵能江 , 孙文杰 , 等 . 针灸在2型糖尿病防治中的实践及获益 [J ] . 中国中西医结合杂志 , 2022 , 42 ( 4 ): 492 - 496 .

朱岚 , 魏燕 , 金剑虹 , 等 . 芪山无糖颗粒治疗湿热困脾证初发2型糖尿病随机对照研究 [J ] . 中国中西医结合杂志 , 2020 , 40 ( 2 ): 154 - 157 .

吕晓静 , 杜丽娜 , 张洁 , 等 . UCP-2、ROS对老年2型糖尿病患者血管内皮功能障碍的调控作用及其机制 [J ] . 中国老年学杂志 , 2020 , 40 ( 19 ): 4076 - 4079 .

中华医学会糖尿病学分会 . 中国2型糖尿病防治指南(2020年版)(上) [J ] . 中国实用内科杂志 , 2021 , 41 ( 8 ): 668 - 695 .

郑筱萸 . 中药新药临床研究指导原则(试行) [M ] . 北京 : 中国医药科技出版社 , 2002 : 236 - 237 .

中华中医药学会 . 糖尿病中医防治指南 [M ] . 北京 : 中国中医药出版社 , 2007 .

廖志红 , 周凤琼 , 梁奕铨 . 生存质量是评价糖尿病治疗的重要指标 [J ] . 中国糖尿病杂志 , 2000 , 8 ( 5 ): 304 - 305 .

李杰 , 杨鸥 , 孔俭 . 交感神经过度激活:一种常见疾病? [J ] . 中国循环杂志 , 2019 , 34 ( 12 ): 1236 - 1239 .

韦贵康 . 脊柱性糖尿病发病特点及中医治疗 [C ] // 中华中医药学会骨伤分会 . 中华中医药学会骨伤分会第四届第二次会议论文汇编 , 2007 : 4 .

李赟 , 冀雨芳 , 郭继龙 , 等 . 脊柱性糖尿病发病机制探讨 [J ] . 空军军医大学学报 , 2022 , 43 ( 5 ): 498 - 501 .

高珊 , 李瑞 , 田环环 . 胃脘下俞穴的古今研究 [J ] . 上海针灸杂志 , 2014 , 33 ( 12 ): 1163 - 1166 .

李利平 , 丁明 . 交感神经调节与糖代谢 [J ] . 国外医学(内分泌学分册) , 2003 , 23 ( 3 ): 191 - 194 .

张启明 , 王义国 , 张健雄 , 等 . 探讨躯体-内脏反射与针刺机制的关系 [J ] . 环球中医药 , 2021 , 14 ( 6 ): 1047 - 1051 .

熊帆 , 王倩 , 蒋骁 , 等 . 迷走神经与糖尿病关系的研究进展 [J ] . 中国糖尿病杂志 , 2023 , 31 ( 5 ): 386 - 389 .

李赟 , 冀雨芳 , 董爱爱 , 等 . 针刀对2型糖尿病大鼠降糖作用及其对胰腺交感神经影响 [J ] . 辽宁中医药大学学报 , 2021 , 23 ( 10 ): 40 - 43,221 .

Liu JL , Ibi D , Taniguchi K , et al . Inflammation improves glucose homeostasis through IKKβ-XBP1s interaction [J ] . Cell , 2016 , 167 ( 4 ): 1052 - 1066.e18 .

Gale JD , Gilbert S , Blumenthal S , et al . Effect of PF-04634817, an oral CCR2/5 chemokine receptor antagonist, on albuminuria in adults with overt diabetic nephropathy [J ] . Kidney Int Rep , 2018 , 3 ( 6 ): 1316 - 1327 .

Park Y , Yang J , Zhang HR , et al . Effect of PAR2 in regulating TNF-α and NAD(P)H oxidase in coronary arterioles in type 2 diabetic mice [J ] . Basic Res Cardiol , 2011 , 106 ( 1 ): 111 - 123 .

Su H , Yuan YX , Wang XM , et al . Inhibition of CTRP9, a novel and cardiac-abundantly expressed cell survival molecule, by TNFα -initiated oxidative signaling contributes to exacerbated cardiac injury in diabetic mice [J ] . Basic Res Cardiol , 2013 , 108 ( 1 ): 315 .

Yoshida K , Ito H , Furuya K , et al . Angiogenesis and VEGF-expressing cells are identified predominantly in the fascia rather than in the muscle during the early phase of dermatomyositis [J ] . Arthritis Res Ther , 2017 , 19 ( 1 ): 272 .

Hu LQ , Chen YQ , Chen TT , et al . A systematic study of mechanism of Sargentodoxa cuneata and Patrinia scabiosifolia against pelvic inflammatory disease with dampness-heat stasis syndrome via network pharmacology approach [J ] . Front Pharmacol , 2020 , 11 : 582520 .

Doyle MS , Collins ES , FitzGerald OM , et al . New insight into the functions of the interleukin-17 receptor adaptor protein Act1 in psoriatic arthritis [J ] . Arthritis Res Ther , 2012 , 14 ( 5 ): 226 .

杨娜娜 , 马欣 , 李月婕 , 等 . 针刺调节自主神经发挥抗炎作用机制的研究现状与思路 [J ] . 针刺研究 , 2023 , 48 ( 6 ): 610 - 617 .

Matthews D , Del Prato S , Mohan V , et al . Insights from VERIFY: early combination therapy provides better glycaemic durability than a stepwise approach in newly diagnosed type 2 diabetes [J ] . Diabetes Ther , 2020 , 11 ( 11 ): 2465 - 2476 .

张欣 , 杨文龙 , 刘方铭 . 三才思想在针刀治疗项痹病中的应用探讨 [J ] . 中国针灸 , 2023 , 43 ( 6 ): 697 - 700 .

刘亚南 , 杨双 , 徐世莲 . 小针刀疗法在病理性疼痛中的研究进展 [J ] . 昆明医科大学学报 , 2021 , 42 ( 2 ): 158 - 161 .

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