Objective

2

To establish and validate a clinical prediction model of acupuncture and moxibustion for Bell's palsy so as to provide a tool for predicting the effect of acupuncture and moxibustion on Bell's palsy.

Methods

2

A total of 269 patients with Bell's palsy were collected from department of acupuncture

moxibustion and tuina

Shengli Oilfield Central Hospital

neurology department

Shenxian County Central Hospital and department of rehabilitation medicine

Dongying Municipal Hospital of TCM from June 2018 to June 2023. All of these cases were treated with acupuncture and moxibustion. Of them

182 cases

from department of acupuncture

moxibustion and tuina

Shengli Oilfield Central Hospital and neurology department

Shenxian County Central Hospital

were randomized into a training group (128 cases) and an internal validation group (54 cases); 87 cases from department of rehabilitation medicine

Dongying Municipal Hospital of TCM were assigned to an external validation group. The clinical data of all of the cases were extracted from the electronic medical record information platform. Using SPSS25.0 and R4.2.3

through univariate and multivariate Logistic regression analysis

the independent factors influencing the effects of acupuncture and moxibustion on Bell's palsy were identified. By means of internal and external validations

the receiver operating characteristic curve (ROC)

the goodness-of-fit curve (GFC) and the decision curve analysis (DCA) were plotted. The sensitivity

specificity

accuracy

positive predictive value and negative predictive value of the model were calculated; and its comprehensive performance was evaluated.

Results

2

The results of the multivariate Logistic regression analysis showed that the independent factors for the unsatisfactory effect on Bell's palsy were advanced age

severe symptoms before treatment

no use of steroids within 72 h of onset

and lack of acupuncture-moxibustion therapy during the acute phase or single acupuncture-moxibustion protocol (

P

<

0.05

P

<

0.01). Based on these factors

nomogram model and online columnar plot prediction tool (https://bmuchen.shinyapps.io/dynnomapp/) were established. The area under the ROC curve of the model was 0.921 (95%

CI

: 0.877

0.966)

0.876 (95%

CI

: 0.787

0.966)

and 0.846 (95%

CI

: 0.766

0.926) in the training group

the internal validation group

and the external validation group

respectively

indicating good predictive value. The model showed a satisfactory calibration curve alignment. The decision threshold in the range of 0 to 0.8 provided clinical benefits for participants. The model exhibited the sensitivity from 65.9% to 88.0%

the spe

cificity ranging from 77.3% to 90.7%

the accuracy from 77.8% to 85.9%

the positive predictive value from 83.3% to 90.1%

and the negative predictive value from 70.8% to 78.7%. The comprehensive evaluation indicated a satisfactory clinical application value of the model.

Conclusion

2

The clinical prediction model of acupuncture and moxibustion for Bell's palsy is valuable in its practice and promotion to a certain extent. The predicted results are conductive to clinicians' judgement of the effect of acupuncture and moxibustion for this disease and making effective and high-quality clinical decisions

as well as formulating the optimal therapeutic regimen.