<italic style="font-style: italic">Tongdu Tiaoshen</italic> acupuncture for subjective tinnitus:a randomized controlled trial

LI Chenglong; MAO Wei; ZHANG Lida; ZHANG Xin; WU Haiyang; ZHANG Guoqing; ZHANG Junyu; WANG Ying; HAN Wei

doi:10.13703/j.0255-2930.20230808-k0001

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Tongdu Tiaoshen acupuncture for subjective tinnitus:a randomized controlled trial

Clinical Research | 更新时间：2024-06-14

- Tongdu Tiaoshen acupuncture for subjective tinnitus:a randomized controlled trial
- Chinese Acupuncture & Moxibustion Vol. 44, Issue 6, Pages: 648-652(2024)
- 作者机构：
  
  1.安徽中医药大学第一临床医学院，合肥　230012
  2.广州医科大学附属脑科医院中医科
  3.南京市高淳区中医院针灸科
  4.安徽中医药大学第二附属医院脑病科，合肥　230001
  5.安徽中医药大学第二附属医院老年病科，合肥　230001
  6.安徽省名中医王颖工作室，合肥　230001
- 作者简介：
- 基金信息：
- DOI：10.13703/j.0255-2930.20230808-k0001
  CLC：
- Received：08 August 2023，
  
  Online First：08 February 2024，
  
  Published：12 June 2024
- 稿件说明：
移动端阅览
LI Chenglong, MAO Wei, ZHANG Lida, et al. Tongdu Tiaoshen acupuncture for subjective tinnitus:a randomized controlled trial[J]. Chinese Acupuncture & Moxibustion, 2024, 44(6): 648-652. DOI: 10.13703/j.0255-2930.20230808-k0001.
DOI：

LI Chenglong, MAO Wei, ZHANG Lida, et al. Tongdu Tiaoshen acupuncture for subjective tinnitus:a randomized controlled trial[J]. Chinese Acupuncture & Moxibustion, 2024, 44(6): 648-652. DOI: 10.13703/j.0255-2930.20230808-k0001. DOI：

摘要

目的：

观察“通督调神”法针刺治疗主观性耳鸣的临床疗效，并探讨其可能的作用机制。

方法：

将92例主观性耳鸣患者随机分为针刺组（46例，脱落5例）和药物组（46例，脱落2例）。针刺组予“通督调神”法针刺治疗，穴取水沟、印堂、神庭、百会、风府、大椎和患侧中渚、听会、翳风，每次30 min，隔日1次，每周3次；药物组予口服银杏叶片（40 mg/次）、甲钴胺片（0.5 mg/次），均每日3次。两组均连续治疗4周。观察两组患者治疗前后耳鸣严重程度评分、耳鸣响度视觉模拟量表（VAS）评分和情绪自评量表（DASS-21）评分，检测治疗前后两组患者血清脑源性神经营养因子（BDNF）含量，并评定临床疗效。

结果：

治疗后，两组患者耳鸣严重程度评分、耳鸣响度VAS评分和DASS-21评分均较治疗前降低（

0.01），且针刺组均低于药物组（

0.05）。治疗后，两组患者血

清BDNF含量均较治疗前降低（

0.01），且针刺组低于药物组（

0.05）。针刺组总有效率为82.9%（34/41），高于药物组的70.5%（31/44，

0.05）。

结论：

“通督调神”法针刺可改善主观性耳鸣患者的耳鸣严重程度、耳鸣响度和不良情绪，其机制可能与调节血清BDNF含量、影响听觉中枢可塑性有关。

Abstract

Objective

To observe the clinical effect of

Tongdu Tiaoshen

acupuncture (acupuncture for promoting the circulation of the governor vessel and regulating the spirit) for subjective tinnitus

and explore its potential mechanism.

Methods

A total of 92 patients with subjective tinnitus were randomly divided into an acupuncture group (46 cases

5 cases dropped out) and a medication group (46 cases

2 cases dropped out). The acupuncture group received

Tongdu Tiaoshen

acupuncture at Shuigou (GV 26)

Yintang (GV 24

)

Shenting (GV 24)

Baihui (GV 20)

Fengfu (GV 16)

Dazhui (GV 14) and Zhongzhu (TE 3)

Tinghui (GB 2)

Yifeng (TE 17) on the affected side

30 min each time

once every other day

3 times a week. The medication group was orally administered ginkgo biloba leaves tablets (40 mg each time) and mecobalamin tablets (0.5 mg each time)

3 times a day. Both groups were treated for 4 weeks. The scores of tinnitus severity

tinnitus loudness visual analogue scale (VAS) and depression anxiety stress scale-21(DASS-21) before and after treatment were observed in the two groups

serum level of brain-derived neurotrophic factor (BDNF) before and after treatment in the two groups was detected

and the clinical effect was evaluated in the two groups.

Results

After treatment

the scores of tinnitus severity

tinnitus loudness VAS and DASS-21 were decreased compared with those before treatment in the two groups (

0.01)

and the scores in the acupuncture group were lower than those in the medication group (

0.05). After treatment

the ser

um level of BDNF was decreased compared with that before treatment in the two groups (

0.01)

and the serum level of BDNF in the acupuncture group was lower than that in the medication group (

0.05). The total effective rate of the acupuncture group was 82.9% (34/41)

which was higher than 70.5% (31/44) in the medication group (

0.05).

Conclusion

Tongdu Tiaoshen

acupuncture could improve the severity of tinnitus

tinnitus loudness and negative emotion in patients with subjective tinnitus. Its mechanism may be related to the regulation of serum level of BDNF and thus affect auditory central plasticity.

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⁰

Tongdu Tiaoshen acupuncture for subjective tinnitus:a randomized controlled trial

DOI：10.13703/j.0255-2930.20230808-k0001

摘要

Abstract

关键词

Keywords

references