Effect of umbilical moxibustion on intestinal flora in patients with subthreshold depression

YU Ziru; XIAN Jin; WANG Ling; YU Huijuan

doi:10.13703/j.0255-2930.20231019-0003

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Effect of umbilical moxibustion on intestinal flora in patients with subthreshold depression

Clinical Research | 更新时间：2024-08-09

- Effect of umbilical moxibustion on intestinal flora in patients with subthreshold depression
- Chinese Acupuncture & Moxibustion Vol. 44, Issue 8, Pages: 881-888(2024)
- 作者机构：
  
  1.山东中医药大学针灸推拿学院，济南　250014
  2.山东中医药大学附属医院治未病中心，济南　250014
- 作者简介：
- 基金信息：
- DOI：10.13703/j.0255-2930.20231019-0003
  CLC：
- Received：19 October 2023，
  
  Online First：22 May 2024，
  
  Published：12 August 2024
- 稿件说明：
移动端阅览
YU Ziru, XIAN Jin, WANG Ling, et al. Effect of umbilical moxibustion on intestinal flora in patients with subthreshold depression[J]. Chinese Acupuncture & Moxibustion, 2024, 44(8): 881-888.
DOI：

YU Ziru, XIAN Jin, WANG Ling, et al. Effect of umbilical moxibustion on intestinal flora in patients with subthreshold depression[J]. Chinese Acupuncture & Moxibustion, 2024, 44(8): 881-888. DOI： 10.13703/j.0255-2930.20231019-0003.

摘要

目的：

观察脐灸治疗阈下抑郁（SD）患者的临床疗效以及对肠道菌群的影响，探讨其作用机制。

方法：

招募36例SD患者作为阈下抑郁组（脱落1例，剔除2例），招募36例健康受试者作为健康对照组（剔除1例）。阈下抑郁组采用脐灸治疗，每周1次，共治疗8次；健康对照组不予任何干预。观察阈下抑郁组治疗前后汉密尔顿抑郁量表17项（HAMD-17）、流调中心抑郁量表（CES-D）评分，并评定临床疗效。分别于阈下抑郁组治疗前后及健康对照组入组时采集粪便样本，采用16S rRNA测序技术分析肠道菌群情况。

结果：

与治疗前比较，阈下抑郁组治疗后HAMD-17、CES-D评分降低（

0.05），总有效率为90.9%（30/33）。与健康对照组比较，阈下抑郁组治疗前Sobs、Shannon、Ace指数降低（

0.05），Simpson指数升高（

0.05），有害菌埃希杆菌-志贺菌属（

Escherichia

Shigella

）相对丰度升高（

0.01），有益菌霍氏真杆菌属（

Eubacterium_hallii_

group）、瘤胃球菌属（

Ruminococcus

）、克里斯滕森菌科R7群（

Christensenellaceae_R

group）、帕拉普氏菌属（

Paraprevotella

）相对丰度降低（

0.05，

0.01）；与治疗前比较，阈下抑郁组治疗后

Escherichia

Shigella

相对丰度降低（

0.01），

Ruminococcus

、

Christensenellaceae_R

group、

Paraprevotella

相对丰度升高（

0.01，

0.0

5）。

Christensenellaceae_R

group、

Paraprevotella

与CES-D评分呈负相关（

0.01，

0.05）；

Escherichia

Shigella

与HAMD-17评分呈正相关（

0.05），

Christensenellaceae_R

group与HAMD-17评分呈负相关（

0.01）。

结论：

SD患者存在肠道菌群紊乱，脐灸可能通过调节肠道菌群的丰度和多样性，增加有益菌，减少有害菌，从而发挥疗效。

Abstract

Objective

To observe the clinical efficacy of umbilical moxibustion for subthreshold depression (SD) and its effect on intestinal flora

and to explore its mechanism.

Methods

Thirty-six SD patients were recruited as the SD group (1 case dropped out

2 cases excluded)

and 36 healthy subjects were recruited as the healthy control group (1 case excluded).The SD group was treated with umbilical moxibustion

once a week

a total of 8 times were required.The healthy control group did not receive any intervention.Hamilton depression scale 17-item (HAMD-17) and Center for Epidemiologic Studies depression scale (CES-D) scores were observed in the SD group before and after treatment

and the clinical efficacy was evaluated.Fecal samples were collected in the SD group before and after treatment and in the healthy control group when enrolled

the intestinal flora was analyzed by 16S rRNA sequencing technology.

Results

The HAMD-17 and CES-D scores after treatment in the SD group were reduced compared with those before treatment (

0.05)

and the total effective rate was 90.9% (30/33).Compared with the healthy control group

Sobs index

Shannon index and Ace index were reduced in the SD group before treatment (

0.05)

Simpson index was increased (

0.05)

the relative abundance of

Escherichia

Shigella

was increased (

0.01)

the relative abundance of

Eubacterium_hallii_

group

Ruminococcus

Christensenellaceae_R

group

Paraprevotella

was decreased (

0.05

0.01).Compared before treatment

the relative abundance of

Escherichia

Shigella

after treatment in the SD group was decreased (

0.01)

the relative abundance of

Ruminococcus

Christensenaceae_R

group

Paraprevotella

was increased (

0.01

0.05).

Christensenellaceae_R

group and

Paraprevotella

were negatively correlated with the CES-D score (

0.01

0.05).

Escherichia

Shigella

was positively correlated with the HAMD-17 score (

0.05).

Christensenellaceae_R

group was negatively correlated with the HAMD-17 score (

0.01).

Conclusion

Patients with subthreshold depression have dysbiosis of intestinal flora

and umbilical moxibustion may exert therapeutic effect by regulating the abundance and diversity of intestinal flora

increasing beneficial bacteria

and reducing harmful bacteria.

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