Neuro-endocrine-immune network mechanism of acupuncture for post-stroke depression

HAN Mingyuan; GAO Ruize; YANG Chengyan; LV Xiaolin; SUN Zhongren; FAN Ying; WANG Yuxin; YIN Hongna

doi:10.13703/j.0255-2930.20240311-k0004

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Neuro-endocrine-immune network mechanism of acupuncture for post-stroke depression

Review | 更新时间：2024-09-25

- Neuro-endocrine-immune network mechanism of acupuncture for post-stroke depression
- Chinese Acupuncture & Moxibustion Vol. 44, Issue 9, Pages: 1100-1106(2024)
- 作者机构：
  
  1.黑龙江中医药大学研究生院，哈尔滨　150040
  2.黑龙江中医药大学附属第二医院，哈尔滨　150000
  3.黑龙江中医药大学附属第一医院
- 作者简介：
- 基金信息：
- DOI：10.13703/j.0255-2930.20240311-k0004
  CLC：
- Received：11 March 2024，
  
  Online First：12 June 2024，
  
  Published：12 September 2024
- 稿件说明：
移动端阅览
HAN Mingyuan, GAO Ruize, YANG Chengyan, et al. Neuro-endocrine-immune network mechanism of acupuncture for post-stroke depression[J]. Chinese Acupuncture & Moxibustion, 2024, 44(9): 1100-1106.
DOI：

HAN Mingyuan, GAO Ruize, YANG Chengyan, et al. Neuro-endocrine-immune network mechanism of acupuncture for post-stroke depression[J]. Chinese Acupuncture & Moxibustion, 2024, 44(9): 1100-1106. DOI： 10.13703/j.0255-2930.20240311-k0004.

摘要

神经、内分泌和免疫系统之间借助神经递质、内分泌激素和细胞因子等联结成神经-内分泌-免疫（NEI）网络，多层次、多系统地将效果信息输出到靶器官。针刺效应可通过NEI网络级联放大，引起穴位局部微环境应答以治疗卒中后抑郁（PSD）。本文分别从神经、内分泌、免疫3个方面系统阐释针刺治疗PSD的机制，并结合NEI网络从整体观揭示针刺治疗PSD的潜在机制与生物学途径，以期为针刺治疗PSD的基础研究提供可靠理论。

Abstract

The nervous

endocrine and immune systems are interconnected through neurotransmitters

endocrine hormones and cytokines

forming a neuro-endocrine-immune (NEI) network that outputs effect information to target organs in a multi-level and multi-system manner. The effects of acupuncture can be amplified through the NEI network

causing local microenvironment responses at acupoints to treat post-stroke depression (PSD). This paper systematically elucidates the mechanisms of acupuncture treatment for PSD from three aspects: nervous

endocrine and immune

and reveals the potential mechanisms and biological pathways of acupuncture treatment for PSD from an overall perspective based on the NEI network

aiming to provide a reliable theoretical basis for fundamental research on acupuncture treatment for PSD.

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Related Institution

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