Electroacupuncture at "four points of sacral region" for mild-to-moderate benign prostatic hyperplasia with lower urinary tract symptoms: a randomized controlled trial

ZHOU Jie; ZHENG Mengyi; CHEN Shan; ZHAO Yiying; MA Ruijie

doi:10.13703/j.0255-2930.20240322-k0003

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Electroacupuncture at "four points of sacral region" for mild-to-moderate benign prostatic hyperplasia with lower urinary tract symptoms: a randomized controlled trial

Clinical Research | 更新时间：2025-05-15

- Electroacupuncture at "four points of sacral region" for mild-to-moderate benign prostatic hyperplasia with lower urinary tract symptoms: a randomized controlled trial
- Chinese Acupuncture & Moxibustion Vol. 45, Issue 5, Pages: 627-632(2025)
- 作者机构：
  
  浙江中医药大学附属第三医院，杭州　310005
  浙江中医药大学第三临床医学院，杭州　310053
  浙江中医药大学附属第一医院
- 作者简介：
- 基金信息：
- DOI：10.13703/j.0255-2930.20240322-k0003
  CLC：
- Received：22 March 2024，
  
  Online First：03 March 2025，
  
  Published：12 May 2025
- 稿件说明：
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ZHOU Jie, ZHENG Mengyi, CHEN Shan, et al. Electroacupuncture at "four points of sacral region" for mild-to-moderate benign prostatic hyperplasia with lower urinary tract symptoms: a randomized controlled trial[J]. Chinese Acupuncture & Moxibustion, 2025, 45(5): 627-632.
DOI：

ZHOU Jie, ZHENG Mengyi, CHEN Shan, et al. Electroacupuncture at "four points of sacral region" for mild-to-moderate benign prostatic hyperplasia with lower urinary tract symptoms: a randomized controlled trial[J]. Chinese Acupuncture & Moxibustion, 2025, 45(5): 627-632. DOI： 10.13703/j.0255-2930.20240322-k0003.

摘要

目的：

观察电针“骶四穴”治疗轻中度良性前列腺增生伴下尿路症状的临床疗效。

方法：

将58例轻中度前列腺增生伴下尿路症状患者随机分为骶四穴电针组（29例，脱落1例）和常规电针组（29例，脱落1例）。骶四穴电针组予电针双侧骶尾关节旁开0.5寸处及会阳穴，常规电针组予电针关元、中极、曲骨及双侧水道、三阴交、足三里，两组均予连续波，频率2 Hz，每次30 min，隔日1次，每周3次，共治疗4周。分别于治疗前、治疗2、4周后及治疗后1个月（随访）时评价两组患者国际前列腺症状评分（IPSS）、膀胱过度活动症评分（OABSS）及生活质量指数（QOL）评分，于治疗前后经腹部B超测定前列腺体积（PV），并于治疗后评定两组临床疗效。

结果：

与治疗前比较，两组患者治疗4周后及随访时IPSS、OABSS及QOL评分降低（

0.01，

0.05）。骶四穴电针组患者治疗4周后及随访时IPSS和QOL评分低于常规电针组（

0.05，

0.01），随访时OABSS评分低于常规电针组（

0.05）；骶四穴电针组患者治疗4周后和随访时IPSS、OABSS评分较治疗前降低幅度大于常规电针组（

0.01，

0.05），治疗2、4周后和随访时QOL评分较治疗前降低幅度大于常规电针组（

0.01）。治疗后，两组患者PV比较差异无统计学意义（

0.05）。骶四穴电针组总有效率为75.0%（21/28），高于常规电针组的39.3%（11/28，

0.01）。

结论：

电针“骶四穴”可有效改善轻中度前列腺增生患者下尿路症状、膀胱过度活动症状和生活质量，具有较好的近期及远期疗效，但不能减小前列腺体积。

Abstract

Objective

To observe the clinical efficacy of electroacupuncture (EA) at "four points of sacral region" for mild-to-moderate benign prostatic hyperplasia (BPH) with lower urinary tract symptoms (LUTS).

Methods

A total of 58 patients with BPH/LUTS were randomly divided into a sacral four-point EA group (29 cases

1 case dropped out) and a conventional EA group (29 cases

1 case dropped out). EA was applied at bilateral points 0.5

cun

lateral to the sacrococcygeal joint and Huiyang (BL35) in the sacral four-point EA group; and was applied at Guanyuan (CV4)

Zhongji (CV3)

Qugu (CV2) and bilateral Shuidao (ST28)

Sanyinjiao (SP6)

Zusanli (ST36) in the conventional EA group. Both groups received continuous wave

2 Hz in frequency

30 min a time

once every other day

3 times a week for 4 weeks. Before treatment

after 2 and 4 weeks of treatment

and in follow-up of 1 month after treatment completion

the international prostate symptom score (IPSS)

the overactive bladder symptom score (OABSS)

the quality of life (QOL) score were observed; before and after treatment

the prostate volume (PV) was measured by abdominal ultrasound; and the clinical efficacy was evaluated after treatment in the two groups.

Results

Compared before treatment

the scores of IPSS

OABSS and QOL were decreased after 4 weeks of treatment and in follow-up in both groups (

0.01

0.05). In the sacral four-point EA group

the scores of IPSS and QOL after 4 weeks of treatment and in follow-up were lower than those in the conventional EA group (

0.05

0.01)

and the OABSS score in follow-up was lower than that in the conventional EA group (

0.05). After 4 weeks of treatment and in follow-up

the reductions of IPSS and OABSS scores compared before treatment in the sacral four-point EA group were larger than those in the conventional EA group (

0.01

0.05); After 2

4 weeks of treatment and in follow-up

the reductions of QOL score compared before treatment in the sacral four-point EA group were larger than those in the conventional EA group (

0.01). No significant difference in PV was observed after treatment between the two groups (

0.05). The total effective rate was 75.0% (21/28) in the sacral four-point EA group

which was higher than 39.3% (11/28) in the conventional EA group (

0.01).

Conclusion

EA at "four points of sacral region" can effectively improve the LUTS

overactive bladder symptom and quality of life in patients with mild-to-moderate BPH

and has good short-term and long-term efficacy

although it can not reduce prostate volume.

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