Clinical efficacy of acupuncture on mild cognitive impairment and its effect on gut microbiota

JIANG Peng; HU Fen; LIN Mian; ZHU Jianfang

doi:10.13703/j.0255-2930.20240424-k0005

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Clinical efficacy of acupuncture on mild cognitive impairment and its effect on gut microbiota

Clinical Research | 更新时间：2025-07-17

- Clinical efficacy of acupuncture on mild cognitive impairment and its effect on gut microbiota
- Chinese Acupuncture & Moxibustion Vol. 45, Issue 7, Pages: 903-910(2025)
- 作者机构：
  
  浙江中医药大学第二临床医学院，杭州　310000
  富春街道社区卫生服务中心
  浙江医院针灸科，杭州　310000
- 作者简介：
- 基金信息：
- DOI：10.13703/j.0255-2930.20240424-k0005
  CLC：
- Received：24 April 2024，
  
  Online First：28 April 2025，
  
  Published：12 July 2025
- 稿件说明：
移动端阅览
JIANG Peng, HU Fen, LIN Mian, et al. Clinical efficacy of acupuncture on mild cognitive impairment and its effect on gut microbiota[J]. Chinese Acupuncture & Moxibustion, 2025, 45(7): 903-910.
DOI：

JIANG Peng, HU Fen, LIN Mian, et al. Clinical efficacy of acupuncture on mild cognitive impairment and its effect on gut microbiota[J]. Chinese Acupuncture & Moxibustion, 2025, 45(7): 903-910. DOI： 10.13703/j.0255-2930.20240424-k0005.

摘要

目的：

观察针刺治疗轻度认知功能障碍（MCI）患者的临床疗效及对肠道菌群的影响。

方法：

将62例MCI患者随机分为试验组（31例，脱落2例）和对照组（31例）。对照组予运动、认知功能训练，试验组在对照组基础上加用针刺治疗，穴取百会、四神聪及双侧风池、悬钟、足三里、养老、心俞等，隔日1次，每周3次，共治疗12周。分别于治疗前后观察两组患者蒙特利尔认知评估量表（MoCA）、简易精神状态检查量表（MMSE）评分，运用16S rDNA测序技术检测肠道菌群变化，并于治疗后评定临床疗效。

结果：

治疗后两组患者MoCA和MMSE评分较治疗前升高（

0.001），且试验组高于对照组（

0.001，

0.05）。治疗后，试验组患者普拉梭菌属（

Faecalibacterium

）、梭菌属（

Clostridia

）、瘤胃球菌科（

Ruminococcaceae

）相对丰度较治疗前升高（

0.05）；试验组患者普拉梭菌属相对丰度高于对照组（

0.05）。试验组总有效率为82.8％（24/29），高于对照组的61.3％（19/31，

0.05）。

结论：

针刺可改善MCI患者认知功能障碍，其机制可能与提高肠道普拉梭菌属、梭菌属、瘤胃球菌科等产丁酸菌相对丰度，维护肠道屏障，抑制相关炎性反应有关。

Abstract

Objective

To observe the clinical efficacy of acupuncture on mild cognitive impairment (MCI) and its effect on gut microbiota.

Methods

A total of 62 MCI patients were randomly divided into an experimental group (31 cases

2 cases dropped out) and a control group (31 cases). Both groups received exercise and cognitive training. In addition

the experimental group underwent acupuncture treatment at acupoints including Baihui (GV20)

Sishencong (EX-HN1)

and bilateral Fengchi (GB20)

Xuanzhong (GB39)

Zusanli (ST36)

Yanglao (SI6)

Xinshu (BL15)

and etc.

once every other day

three times per week

for a total of 12 weeks. Before and after treatment

the Montreal cognitive assessment (MoCA) and mini-mental state examination (MMSE) scores were evaluated in the two groups

changes in gut microbiota were detected using 16S rDNA sequencing technology. The clinical efficacy was assessed after treatment.

Results

Compared before treatment

MoCA and MMSE scores were increased in both groups after treatment (

0.001)

with higher scores in the experimental group than those in the control group (

0.001

0.05). After treatment

the relative abundance of

Faecalibacterium

Clostridia

and

Ruminococcaceae

was increased in the experimental group compared with that before treatment (

0.05). Moreover

the relative abundance of

Faecalibacterium

in the experimental group was higher than that in the control group (

0.05). The total effective rate was 82.8% (24/29) in the experimental group

which was higher than 61.3% (19/31) in the control group (

0.05).

Conclusion

Acupuncture could improve cognitive dysfunction in patients with MCI

and its mechanism may be related to increasing the relative abundance of butyrate-producing bacteria such as

Faecalibacterium

Clostridia

and

Ruminococcaceae

maintaining the intestinal barrier

and inhibiting related inflammatory responses.

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