Mechanism research progress on acupuncture-moxibustion therapy for functional gastrointestinal disorders: review and prospects

FANG Yucheng; ZHU Jingwei; WANG Ziye; LI Kuiwu; DING Xuechun; WANG Ning; CHU Haoran

doi:10.13703/j.0255-2930.20240603-k0002

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Mechanism research progress on acupuncture-moxibustion therapy for functional gastrointestinal disorders: review and prospects

Review | 更新时间：2025-04-11

- Mechanism research progress on acupuncture-moxibustion therapy for functional gastrointestinal disorders: review and prospects
- Chinese Acupuncture & Moxibustion Vol. 45, Issue 4, Pages: 551-558(2025)
- 作者机构：
  
  安徽中医药大学，合肥　230031
  安徽中医药大学第二临床医学院，合肥　230061
  深圳市罗湖区中医院
  安徽省中医药科学院针灸临床研究所，合肥　230061
  安徽省针灸临床医学研究中心，合肥　230061
  安徽中医药大学新安医学与中医药现代化研究所，合肥　230012
- 作者简介：
- 基金信息：
- DOI：10.13703/j.0255-2930.20240603-k0002
  CLC：
- Received：03 June 2024，
  
  Online First：08 February 2025，
  
  Published：12 April 2025
- 稿件说明：
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FANG Yucheng, ZHU Jingwei, WANG Ziye, et al. Mechanism research progress on acupuncture-moxibustion therapy for functional gastrointestinal disorders: review and prospects[J]. Chinese Acupuncture & Moxibustion, 2025, 45(4): 551-558.
DOI：

FANG Yucheng, ZHU Jingwei, WANG Ziye, et al. Mechanism research progress on acupuncture-moxibustion therapy for functional gastrointestinal disorders: review and prospects[J]. Chinese Acupuncture & Moxibustion, 2025, 45(4): 551-558. DOI： 10.13703/j.0255-2930.20240603-k0002.

摘要

针灸被认为可以改善功能性胃肠病（FGIDs）症状，然而其具体作用机制至今仍不明确。本文梳理近5年关于针灸治疗FGIDs的文献，发现针灸可通过调节胃肠动力、调节内脏高敏感、改善胃-十二指肠黏膜屏障功能受损及炎性反应、调节肠道菌群失衡、调控脑-肠轴来改善FGIDs相关症状。目前，针灸治疗FGIDs的分子机制仍不清晰，其具体的疾病靶点不甚明确，对各分子间相互作用机制的阐述欠完备，未来仍需要利用更先进的研究技术及手段进行深入、全面的探究，以阐明针灸治疗FGIDs的起效机制。

Abstract

Acupuncture-moxibustion therapy has been known to ameliorate the symptoms of functional gastrointestinal disorders (FGIDs)

although its mechanism remains unclear. The paper reviews the articles on acupuncture-moxibustion therapy for FGIDs in recent 5 years

and it is revealed that acupuncture-moxibustion therapy can alleviate FGIDs symptoms through regulating gastrointestinal motility

modulating visceral hypersensitivity

improving the impaired gastric-duodenal mucosal barrier and inflammation

balancing intestinal microbiota

and adjusting the gut-brain axis. Currently

the molecular mechanism of acupuncture-moxibustion therapy remains unknown for FGIDs

the specific disease target is not identified

and the interaction among various molecules is not elucidated adequately. The researches in the future should employ advanced technologies and methodologies to comprehensively and deeply explore and clarify the mechanism of acupuncture- moxibustion therapy for FGIDs.

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