Effects of <italic style="font-style: italic">Tiaoshu Anshen</italic> acupuncture on sleep quality and serum neurotransmitter levels in patients with chronic insomnia

LIU Lian; YAN Tianya; CHEN Zhuangzhi; KANG Zhen; LI Mengyao; GAO Qiongjue; QIN Zuoai; WEN Yecheng; LIU Weiai; FU Zhongying

doi:10.13703/j.0255-2930.20240613-k0006

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Effects of Tiaoshu Anshen acupuncture on sleep quality and serum neurotransmitter levels in patients with chronic insomnia

Clinical Research | 更新时间：2025-02-14

- Effects of Tiaoshu Anshen acupuncture on sleep quality and serum neurotransmitter levels in patients with chronic insomnia
- Chinese Acupuncture & Moxibustion Vol. 45, Issue 2, Pages: 151-155(2025)
- 作者机构：
  
  湖南中医药大学第二附属医院针灸推拿康复科，长沙　410005
- 作者简介：
- 基金信息：
- DOI：10.13703/j.0255-2930.20240613-k0006
  CLC：
- Received：13 June 2024，
  
  Online First：28 November 2024，
  
  Published：12 February 2025
- 稿件说明：
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LIU Lian, YAN Tianya, CHEN Zhuangzhi, et al. Effects of Tiaoshu Anshen acupuncture on sleep quality and serum neurotransmitter levels in patients with chronic insomnia[J]. Chinese Acupuncture & Moxibustion, 2025, 45(2): 151-155. DOI: 10.13703/j.0255-2930.20240613-k0006.
DOI：

LIU Lian, YAN Tianya, CHEN Zhuangzhi, et al. Effects of Tiaoshu Anshen acupuncture on sleep quality and serum neurotransmitter levels in patients with chronic insomnia[J]. Chinese Acupuncture & Moxibustion, 2025, 45(2): 151-155. DOI: 10.13703/j.0255-2930.20240613-k0006. DOI：

摘要

目的：

观察调枢安神法针刺对慢性失眠症患者睡眠质量及血清神经递质5-羟色胺（5-HT）、多巴胺（DA）含量的影响。

方法：

将58例慢性失眠症患者随机分为针刺组（29例）和西药组（29例）。针刺组采用调枢安神法针刺治疗，穴取百会及双侧神门、三阴交、本神，每日1次，连续治疗6 d后休息1 d；西药组睡前口服艾司唑仑片治疗，每次1 mg，两组均治疗4周。分别于治疗前后运用匹兹堡睡眠质量指数（PSQI）评分和多导睡眠监测（PSG）评估患者睡眠质量，采用ELISA法检测患者血清5-HT、DA含量。

结果：

治疗后，两组患者PSQI各项评分及总分均降低(

0.05)，针刺组患者PSQI睡眠质量、入睡时间、睡眠时间、睡眠效率、睡眠障碍评分及总分低于西药组(

0.05)。治疗后，两组患者总睡眠时间（TST）延长（

0.05），睡眠潜伏期（SL）和入睡后清醒时间（WASO）缩短（

0.05），睡眠效率（SE%）、非快速眼动睡眠第3期百分比（N3%）、快速眼动睡眠百分比（REM%）、血清5-HT含量较治疗前升高（

0.05），非快速眼动睡眠第1期百分比（N1%）、非快速眼动睡眠第2期百分比（N2%）、血清DA含量较治疗前降低（

0.05）；针刺组患者TST长于西药组（

0.05），SL和WASO短于西药组（

0.05），SE%、N3%、REM%、血清5-HT含量高于西药组（

0.05），N1%、N2%、血清DA含量低于西药组（

0.05）。

结论：

调枢安神法针刺可能通过调节血清神经递质5-HT、DA含量，进而改善慢性失眠症患者睡眠质量。

Abstract

Objective

To observe the effects of

Tiaoshu Anshen

(regulating the hinge and calming the mind) acupuncture on sleep quality and serum levels of 5-hydroxytryptamine (5-HT) and dopamine (DA) in patients with chronic insomnia.

Methods

A total of 58 patients with chronic insomnia were randomly divided into an acupuncture group and a medication group

29 cases in each group.

Tiaoshu Anshen

acupuncture was applied at Baihui (GV20) and bilateral Shenmen (HT7)

Sanyinjiao (SP6)

Benshen (GB13) in the acupuncture group

once a day

1-day interval was taken after 6 consecutive days of treatment. Estazolam tablet was given orally before bed in the medication group

1 mg each time. The 4-week treatment was required in both groups. Before and after treatment

the sleep quality was assessed by Pittsburgh sleep quality index (PSQI) and polysomnography (PSG)

the serum levels of 5-HT and DA were detected by ELISA.

Results

After treatment

the item scores and total

scores of PSQI were decreased compared with those before treatment in the two groups (

0.05); in the acupuncture group

the scores of sleep quality

sleep latency

sleep time

sleep efficiency

sleep disorders and total score of PSQI were lower than those in the medication group (

0.05). After treatment

the total sleep time (TST) was prolonged (

0.05)

the sleep latency (SL) and wake after sleep onset (WASO) were shortened (

0.05)

the sleep efficiency (SE%)

percentage of non-rapid eye movement stage 3 (N3%)

percentage of rapid eye movement stage (REM%) and serum levels of 5-HT were increased (

0.05) compared with those before treatment; the percentage of non-rapid eye movement stage 1 (N1%)

percentage of non-rapid eye movement stage 2 (N2%) and serum levels of DA were decreased (

0.05) compared with those before treatment in the two groups. After treatment

in the acupuncture group

TST was longer

while SL and WASO were shorter than those in the medication group (

0.05)

SE%

N3%

REM% and serum level of 5-HT were higher

while N1%

N2% and serum level of DA were lower than those in the medication group (

0.05).

Conclusion

Tiaoshu Anshen

acupuncture may improve the sleep quality by regulating the serum neurotransmitter levels i.e. 5-HT and DA in patients with chronic insomnia.

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⁰

Effects of Tiaoshu Anshen acupuncture on sleep quality and serum neurotransmitter levels in patients with chronic insomnia

DOI：10.13703/j.0255-2930.20240613-k0006

摘要

Abstract

关键词

Keywords

references