Objective

2

To observe the clinical efficacy of heat-sensitive moxibustion combined with western medication for preconception intervention in prethrombotic state of recurrent spontaneous abortion (RSA) with kidney deficiency and blood stasis.

Methods

2

A total of 100 RSA patients of prethrombotic state with kidney deficiency and blood stasis were randomized into a combination group (50 cases

5 cases were eliminated) and a medication group (50 cases

5 cases were eliminated). In the medication group

the aspirin enteric-coated tablet was given orally at a dose of 75 mg a time

once daily. On the basis of the treatment in the medication group

in the combination group

heat-sensitive moxibustion was applied at the heat-sensitive points selected among the areas of Guanyuan (CV4)

Shenque (CV8)

and bilateral Sanyinjiao (SP6)

Zusanli (ST36)

Qihai (CV6)

Taixi (KI3)

Zigong (EX-CA1)

Luanchao (Extra)

Xuehai (SP10)

and Yinlingquan (SP9)

about 40 min a time

once every two days. Both groups were treated for 3 menstrual cycles continuously. Pregnancy success rate of 12 weeks was recorded in the two groups in follow-up of 3 months after treatment completion

during which conception was tried under the guidance of doctor. The TCM symptom score was observed and the coagulation-fibrinolysis indexes (activated partial thromboplastin time [APTT]

prothrombin time [PT]

platelet count [PLT]

D-dimer [D-D]

fibrinogen [FIB]

protein S [PS]

protein C [PC] and antithrombin Ⅲ [AT-Ⅲ]) were detected before and after treatment in the two groups.

Results

2

The pregnancy success rate of 12 weeks was 80.0% (32/40) in the combination group

which was higher than 54.3% (19/35) in the medication group (

P

<

0.05). After treatment

the TCM symptom scores were decreased compared with those before treatment in the two groups (

P

<

0.05)

and the TCM symptom score in the combination group was lower than that in the medication group (

P

<

0.05). Compared before treatment

the APTT and PT was prolonged (

P

<

0.05)

the levels of PLT

FIB and D-D were reduced (

P

<

0.05)

the activity of AT-Ⅲ

PS and PC was increased (

P

<

0.05) after treatment in the two groups. After treatment

in the combination group

the APTT was longer (

P

<

0.05)

the levels of PLT

FIB and D-D were lower (

P

<

0.05)

the activity of AT-Ⅲ

PS and PC was higher (

P

<

0.05) than those in the medication group.

Conclusion

2

Heat-sensitive moxibustion combined with western medication can effectively improve the prethrombotic state and TCM clinical symptoms in RSA patients with kidney deficiency and blood stasis

enhance pregnancy success rate

its mechanism may be related to ameliorating hypercoagulability.