<italic style="font-style: italic">Tiaoshen Guben</italic> holistic therapy of acupuncture and moxibustion for 24 cases of comorbidity of depression and insomnia

LI Zhongxian; ZHANG Pan; JI Qiaoyu; PENG Min; JIAO Zitong; ZHOU Yifu; LIANG Junquan; YAN Luda; FU Wenbin; ZHOU Peng

doi:10.13703/j.0255-2930.20241118-k0001

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Tiaoshen Guben holistic therapy of acupuncture and moxibustion for 24 cases of comorbidity of depression and insomnia

Clinical Research | 更新时间：2025-11-20

- Tiaoshen Guben holistic therapy of acupuncture and moxibustion for 24 cases of comorbidity of depression and insomnia
- Chinese Acupuncture & Moxibustion Vol. 45, Issue 11, Pages: 1559-1564(2025)
- 作者机构：
  
  广州中医药大学第七临床医学院，广东深圳　518100
  深圳市宝安区中医院针灸科，广东深圳　518100
  广东省中医院针灸科
- 作者简介：
- 基金信息：
- DOI：10.13703/j.0255-2930.20241118-k0001
  CLC：
- Received：18 November 2024，
  
  Online First：14 May 2025，
  
  Published：12 November 2025
- 稿件说明：
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LI Zhongxian, ZHANG Pan, JI Qiaoyu, et al. Tiaoshen Guben holistic therapy of acupuncture and moxibustion for 24 cases of comorbidity of depression and insomnia[J]. Chinese Acupuncture & Moxibustion, 2025, 45(11): 1559-1564. DOI: 10.13703/j.0255-2930.20241118-k0001.
DOI：

LI Zhongxian, ZHANG Pan, JI Qiaoyu, et al. Tiaoshen Guben holistic therapy of acupuncture and moxibustion for 24 cases of comorbidity of depression and insomnia[J]. Chinese Acupuncture & Moxibustion, 2025, 45(11): 1559-1564. DOI: 10.13703/j.0255-2930.20241118-k0001. DOI：

摘要

目的：

观察调神固本整合针灸治疗抑郁失眠共病的临床疗效。

方法：

纳入24例抑郁失眠共病患者，均接受调神固本整合针灸治疗，针刺穴取百会、关元及双侧内关等，精灸穴取中脘、气海及双侧涌泉等，揿针穴取双侧心俞、脾俞等，均隔日1次，每周3次，共治疗6周。于治疗前后及治疗后1个月采用匹兹堡睡眠质量指数（PSQI）和汉密尔顿抑郁量表（HAMD-17）评估患者睡眠及抑郁情况，于治疗前后采用功能磁共振成像（fMRI）评估患者蓝斑脑区功能连接（FC）状态，检测患者治疗前后血清去甲肾上腺素（NE）、皮质醇（CORT）、促肾上腺皮质激素（ACTH）及促肾上腺皮质激素释放激素（CRH）含量。

结果：

与治疗前比较，患者治疗后及治疗后1个月PSQI、HAMD-17评分均降低（

0.01）。与治疗前比较，患者治疗后右侧蓝斑与左额下回岛盖部及左外侧枕叶区域FC增强。治疗后患者血清NE含量升高（

0.01），血清CORT、ACTH及CRH含量降低（

0.01）。治疗前后右侧蓝斑-左额下回岛盖部FC差值与PSQI评分差值（

＝-0.484，

=0.016）及HAMD-17评分差值（

＝-0.233，

=0.027）均呈负相关。

结论：

调神固本整合针灸可能通过降低血清CORT、ACTH及CRH含量，提高血清NE含量，增强右侧蓝斑与左额下回岛盖部及左外侧枕叶的功能连接，进而有效改善抑郁失眠共病患者的抑郁症状及睡眠质量。

Abstract

Objective

To observe the clinical effect of

Tiaoshen Guben

holistic therapy of acupuncture and moxibustion (holistic treatment with acupuncture and moxibustion by adjusting the mind and consolidating the root) on comorbidity of depression and insomnia.

Methods

Twenty-four patients with comorbidity of depression and insomnia were included and treated with

Tiaoshen Guben

holistic therapy of acupuncture and moxibustion. Acupuncture was applied to Baihui (GV20)

Guanyuan (CV4)

bilateral Neiguan (PC6)

etc. The refined moxibustion therapy was delivered at Zhongwan (CV12)

Qihai (CV6)

bilateral Yongquan (KI1)

etc. Subcutaneous embedding therapy with thumb-tack needle was adopted at bilateral Xinshu (BL15)

bilateral Pishu (BL20)

etc. The intervention was operated once every other day

3 treatments a week

and for 6 consecutive weeks. Before and after treatment completion

and in 1 month after treatment

Pittsburgh sleep quality index (PSQI) and Hamilton's depression scale (HAMD-17) were adopted to assess sleep quality and depression symptoms in the patients

respectively. Before and after treatment completion

using functional magnetic resonance imaging (fMRI)

the functional connectivity (FC) of locus coeruleus (LC) in brain regions was evaluated; and the levels of serum norepinephrine (NE)

cortisol (CORT)

adrenocorticotropic hormone (ACTH) and corticotropin releasing hormone (CRH) were detected.

Results

Compared with the scores before treatment

PSQI and HAMD-17 scores after treatment completion and in 1 month after treatment were reduced (

0.01); and strengthened FC was revealed between the right LC and the pars opercularis of the left inferior frontal gyrus

as well as the lateral occipital lobe r

egion. After treatment completion

serum NE was elevated (

0.01)

the levels of CORT

ACTH and CRH were reduced (

0.01). Before and after treatment completion

the difference in FC between the right LC and the pars opercularis of the left inferior frontal gyrus was negatively correlated with the differences in PSQI score (

= -0.484

= 0.016) and HAMD-17 score (

= -0.233

= 0.027).

Conclusion

Tiaoshen Guben

holistic therapy of acupuncture and moxibustion can effectively alleviate depression symptoms and improve sleep quality in the patients with comorbidity of depression and insomnia

which is obtained probably through reducing the levels of serum CORT

ACTH and CRH

increasing serum NE

strengthening the FC of the right LC with the pars opercularis of the left inferior frontal gyrus and the lateral occipital lobe region.

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⁰

Tiaoshen Guben holistic therapy of acupuncture and moxibustion for 24 cases of comorbidity of depression and insomnia

DOI：10.13703/j.0255-2930.20241118-k0001

摘要

Abstract

关键词

Keywords

references