Exploring the mechanism of core acupoints of acupuncture treatment for ovarian function decline-related diseases based on complex network technology

TAN Yanping; YANG Lilin; WU Haiwang; XU Haixia; ZHAI Fengxia

doi:10.13703/j.0255-2930.20241222-k0002

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Exploring the mechanism of core acupoints of acupuncture treatment for ovarian function decline-related diseases based on complex network technology

Literature Research | 更新时间：2026-01-16

- Exploring the mechanism of core acupoints of acupuncture treatment for ovarian function decline-related diseases based on complex network technology
- Chinese Acupuncture & Moxibustion Vol. 46, Issue 1, Pages: 139-148(2026)
- 作者机构：
  
  广州中医药大学第一临床医学院，广东广州　510405
  广州中医药大学第一附属医院妇科，广东广州　510405
- 作者简介：
- 基金信息：
- DOI：10.13703/j.0255-2930.20241222-k0002
  CLC：
- Received：22 December 2024，
  
  Online First：27 March 2025，
  
  Published：12 January 2026
- 稿件说明：
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TAN Yanping, YANG Lilin, WU Haiwang, et al. Exploring the mechanism of core acupoints of acupuncture treatment for ovarian function decline-related diseases based on complex network technology[J]. Chinese Acupuncture & Moxibustion, 2026, 46(1): 139-148.
DOI：

TAN Yanping, YANG Lilin, WU Haiwang, et al. Exploring the mechanism of core acupoints of acupuncture treatment for ovarian function decline-related diseases based on complex network technology[J]. Chinese Acupuncture & Moxibustion, 2026, 46(1): 139-148. DOI： 10.13703/j.0255-2930.20241222-k0002.

摘要

目的：

采用复杂网络技术探讨针灸治疗卵巢功能减退类疾病的腧穴配伍规律，运用网络针灸学方法分析核心腧穴的作用机制。

方法：

检索中国期刊全文数据库（CNKI）、万方数据知识服务平台（Wanfang）、维普网（VIP）、中国生物医学文献服务系统（SinoMed）、PubMed、EMbase、Cochrane Library、Web of Science数据库建库至2024年4月8日收录的针灸治疗卵巢功能减退类疾病的文献，对选用腧穴进行频次分析、关联规则分析及复杂网络分析，筛选出核心腧穴处方。在检索到的文献中进行核心腧穴靶点挖掘，在GeneCards数据库、Therapeutic Target数据库和DisGeNET数据库中挖掘卵巢功能减退类疾病靶点。利用STRING数据库对交集靶点进行蛋白互作网络构建，使用R语言进行基因本体（GO）富集分析和京都百科全书基因与基因组（KEGG）通路富集分析，通过Cytoscape软件构建针灸治疗卵巢功能减退类疾病的“核心腧穴-靶点-通路”网络图。

结果：

最终纳入文献133篇，共提取186条腧穴处方，包括101个腧穴。核心穴方由15个腧穴组成，挖掘得到73个腧穴靶点，涉及13个核心腧穴，包括关元、三阴交、肾俞、中脘、足三里、中极、气海、百会、太冲、太溪、次髎、子宫和归来。核心腧穴与卵巢功能减退类疾病的交集靶点有40个，其中肿瘤蛋白53、蛋白激酶Bα、白细胞介素1beta、白细胞介素6、白细胞介素10、肿瘤坏死因子、核因子kappa B亚基1是关键靶点，涉及辅助性T细胞（Th）17细胞分化、炎症性肠病、乙型肝炎、甲型流感、人类免疫缺陷病毒1感染等多条信号通路，调控细胞凋亡、炎性反应、免疫应答等生物过程。

结论：

针灸干预卵巢功能减退类疾病的核心腧穴通过作用于多靶点、多通路共同发挥延缓卵巢衰老作用，为腧穴处方的机制研究提供理论基础。

Abstract

Objective

To explore the acupoint compatibility patterns of acupuncture for ovarian function decline-related diseases using complex network technology

and to analyze the mechanism of core acupoints through network acupuncture methods.

Methods

Literature regarding acupuncture for ovarian function decline-related diseases was retrieved from CNKI

Wanfang

VIP

SinoMed

PubMed

EMbase

Cochrane Library

and Web of Science databases from their inception to April 8th

2024. Frequency analysis

association rule analysis

and complex network analysis were conducted on the selected acupoints to identify core acupoint prescriptions. Core acupoint targets were analyzed from the retrieved literature

and targets for ovarian function decline-related diseases were identified using GeneCards

Therapeutic Target

and DisGeNET databases. Protein-protein interaction (PPI) networks were constructed for intersecting targets using the STRING database. gene ontology (GO) enrichment analysis and Kyoto encyclopedia of genes and genomes (KEGG) pathway enrichment analysis were performed using R software. A "core acupoint-target-pathway" network diagram of acupuncture for ovarian function decline-related diseases was constructed using Cytoscape software.

Results

A total of 133 studies were included

extracting 186 acupoint prescriptions involving 101 acupoints. The core prescription consisted of 15 acupoints

and 73 acupoint targets were identified

involving 13 core acupoints

including Guanyuan (CV4)

Sanyinjiao (SP6)

Shenshu (BL23)

Zhongwan (CV12)

Zusanli (ST36)

Zhongji (CV3)

Qihai (CV6)

Baihui (GV20)

Taichong (LR3)

Taixi (KI3)

Ciliao (BL32)

Zigong (EX-CA1)

and Guilai (ST29). There were 40 intersecting targets between the core acupoints and ovarian function decline-related diseases

with key targets including tumor protein 53

protein kinase B alpha

interleukin 1 beta

interleukin 6

interleukin 10

tumor necrosis factor

and nuclear factor kappa B subunit 1. These targets were associated with multiple signaling pathways such as T-helper 17 (Th17) cell differentiation

inflammatory bowel disease

hepatitis B

influenza A

and human immunodeficiency virus 1 (HIV-1) infection

regulating biological processes including apoptosis

inflammatory response

and immune response.

Conclusion

The core acupoints of acupuncture for ovarian function decline-related diseases exert therapeutic effects by acting on multiple targets and pathways

thereby delaying ovarian aging. This provides a theoretical basis for the mechanism research of acupoint prescriptions.

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