<italic style="font-style: italic">Longsha Kaihe Liuqi</italic> acupuncture in treatment of primary open angle glaucoma: a randomized controlled trial

SUN Wenying; ZHANG Lixia; YANG Wei; CHEN Xi; YANG Xiaonan; LI Xuefei; SHI Yipeng; ZHANG Feng; BAO Yuyan; XIE Xiaobin

doi:10.13703/j.0255-2930.20250109-k0004

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Longsha Kaihe Liuqi acupuncture in treatment of primary open angle glaucoma: a randomized controlled trial

Clinical Research | 更新时间：2026-03-16

- Longsha Kaihe Liuqi acupuncture in treatment of primary open angle glaucoma: a randomized controlled trial
- Chinese Acupuncture & Moxibustion Vol. 46, Issue 3, Pages: 353-360(2026)
- 作者机构：
  
  中国中医科学院眼科医院目系眼病科，北京　100040
  首都医科大学附属北京世纪坛医院眼科，北京　100038
- 作者简介：
- 基金信息：
- DOI：10.13703/j.0255-2930.20250109-k0004
  CLC：
- Received：09 January 2025，
  
  Online First：25 December 2025，
  
  Published：12 March 2026
- 稿件说明：
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SUN Wenying, ZHANG Lixia, YANG Wei, et al. Longsha Kaihe Liuqi acupuncture in treatment of primary open angle glaucoma: a randomized controlled trial[J]. Chinese Acupuncture & Moxibustion, 2026, 46(3): 353-360. DOI: 10.13703/j.0255-2930.20250109-k0004.
DOI：

SUN Wenying, ZHANG Lixia, YANG Wei, et al. Longsha Kaihe Liuqi acupuncture in treatment of primary open angle glaucoma: a randomized controlled trial[J]. Chinese Acupuncture & Moxibustion, 2026, 46(3): 353-360. DOI: 10.13703/j.0255-2930.20250109-k0004. DOI：

摘要

目的：

观察龙砂开阖六气针法治疗原发性开角型青光眼（POAG）的临床疗效。

方法：

将78例POAG患者随机分为观察组（39例，剔除4例）和对照组（39例，脱落1例，剔除3例）。对照组予降眼压滴眼液治疗；观察组在对照组治疗基础上，联合龙砂开阖六气针法，根据患者24 h眼压曲线峰值结合辨证，选取2～3个病变经别，以百会穴为中心画一直径为5～8 cm的圆，依据顾氏三阴三阳开阖枢图，在所选之经区域找到压痛点进行针刺，留针1 h，每周1次。两组均治疗4周。观察两组治疗前后24 h眼压及观察组针刺前后即刻眼压，比较两组治疗前后最佳矫正视力（BCVA）、视野相关指标[视野指数（VFI）、平均偏差（MD）、模式标准差（PSD）]、视盘区血流密度、中医证候评分。

结果：

观察组治疗后24 h眼压平均值、峰值、谷值、波动值及MD绝对值均较治疗前降低（

0.05），VFI较治疗前升高（

0.05），治疗后0：00、2：00、5：00、22：00时间点眼压均较治疗前同时点降低（

0.05）；观察组每次针刺后即刻眼压均较针刺前降低（

0.05）。治疗后，观察组中医证候分项评分（眼胀眼痛、目睛干涩、头痛、烦躁易怒、睡眠不安）及总分较治疗前降低（

0.05），且低于对照组（

0.05）。治疗后，两组BCVA、PSD、视盘区血流密度比较，差异无统计学意义（

0.05）。

结论：

龙砂开阖六气针法联合降眼压滴眼液治疗能降低POAG患者眼压及干预24 h眼压节律，改善视野及中医证候。

Abstract

Objective

To observe the clinical effect of

Longsha Kaihe Liuqi

acupuncture on primary open angle glaucoma (POAG).

Methods

A total of 78 POAG patients were randomized into an observation group (39 cases

4 cases eliminated) and a control group (39 cases

1 case dropped out

3 cases eliminated). In the control group

the eye drops for lowering intraocular pressure (IOP) were administered. In the observation group

besides the intervention as the control group

Longsha Kaihe Liuqi

acup

uncture was delivered. According to the 24 h intraocular pressure curve peak and in association with syndrome differentiation

2 or 3 lesion grades were determined. Centered at Baihui (GV20)

a circle with a diameter of 5 cm to 8 cm was drawn. Based on

's "three-

yin

three-

yang

open

close and pivot" diagram

the tender points were detected along the distribution of the affected meridians and stimulated with acupuncture. The needles were retained for 1 h and the intervention was operated once weekly. The duration of treatment was 4 weeks in the two groups. The 24 h IOP before and after treatment in the two groups

and the immediate IOP before and after acupuncture in the observation group were observed. The best corrected visual acuity (BCVA)

visual field-related indexes such as visual field index (VFI)

mean deviation (MD)

and pattern standard deviation (PSD)

optic disc blood flow density and TCM syndrome score were compared between the two groups before and after treatment.

Results

In the observation group

the mean

peak

valley

fluctuation value of 24 h IOP

and absolute MD were all reduced after treatment when compared with those before treatment (

0.05)

while VFI increased (

0.05). At the time points of 0: 00

2: 00

5: 00

and 22: 00 after treatment

IOP was lower than that at each corresponding time point before treatment (

0.05) in the observation group

and the immediate IOP after each acupuncture session was lower than that before acupuncture (

0.05). After treatment

the score of each TCM syndrome (eye swelling and pain

dry eyes

headache

irritability and sleep disturbance) and the total score were reduced when compared with those before treatment in the observation group (

0.05)

and lower than those in the control group (

0.05). After treatment

the differences in BCVA

PSD and optic

disc blood flow density were not statistically significant between the two groups (

0.05).

Conclusion

Longsha Kaihe Liuqi

acupuncture combined with intraocular pressure-lowering eye drops can reduce IOP and regulate 24 h intraocular pressure rhythm

improve visual field and ameliorate TCM syndromes of POAG patients.

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⁰

Longsha Kaihe Liuqi acupuncture in treatment of primary open angle glaucoma: a randomized controlled trial

DOI：10.13703/j.0255-2930.20250109-k0004

摘要

Abstract

关键词

Keywords

references