Effect of medicated-thread moxibustion of Zhuang medicine on amnestic mild cognitive impairment with sleep disorder and its influence on event-related potential P300

ZHAO Lihua; HUANG Nan; ZHOU Yanying; ZHOU Lu; HUANG Dingjian; HUANG Xinge

doi:10.13703/j.0255-2930.20250113-k0008

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Effect of medicated-thread moxibustion of Zhuang medicine on amnestic mild cognitive impairment with sleep disorder and its influence on event-related potential P300

Clinical Research | 更新时间：2026-05-12

- Effect of medicated-thread moxibustion of Zhuang medicine on amnestic mild cognitive impairment with sleep disorder and its influence on event-related potential P300
- Chinese Acupuncture & Moxibustion Vol. 46, Issue 5, Pages: 704-712(2026)
- 作者机构：
  
  广西中医药大学第一附属医院，针灸科，南宁　530023
  广西中医药大学第一附属医院，脑电图科，南宁　530023
  广西中医药大学研究生院
  广西中医药大学第一附属医院仁爱分院，南宁　530000
- 作者简介：
- 基金信息：
- DOI：10.13703/j.0255-2930.20250113-k0008
  CLC：
- Received：13 January 2025，
  
  Online First：26 February 2026，
  
  Published：12 May 2026
- 稿件说明：
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ZHAO Lihua, HUANG Nan, ZHOU Yanying, et al. Effect of medicated-thread moxibustion of Zhuang medicine on amnestic mild cognitive impairment with sleep disorder and its influence on event-related potential P300[J]. Chinese Acupuncture & Moxibustion, 2026, 46(5): 704-712.
DOI：

ZHAO Lihua, HUANG Nan, ZHOU Yanying, et al. Effect of medicated-thread moxibustion of Zhuang medicine on amnestic mild cognitive impairment with sleep disorder and its influence on event-related potential P300[J]. Chinese Acupuncture & Moxibustion, 2026, 46(5): 704-712. DOI： 10.13703/j.0255-2930.20250113-k0008.

摘要

目的：

观察壮医药线点灸治疗遗忘型轻度认知障碍（aMCI）伴睡眠障碍的临床疗效。

方法：

将64例aMCI伴睡眠障碍患者随机分为观察组（32例，剔除1例）和对照组（32例，脱落1例）。对照组予健康教育。观察组在对照组基础上，予药线点灸治疗，穴取百会、关元及双侧足三里、三阴交，第1个月隔日治疗1次，第2、3个月每周治疗2次，共治疗30次。观察两组患者治疗前后蒙特利尔认知评估量表（MoCA）、匹兹堡睡眠质量指数（PSQI）、世界卫生组织生存质量测定量表简表（WHOQOL-BREF）评分，检测两组患者事件相关电位P300的潜伏期及振幅，并评定两组认知功能、睡眠质量方面的临床疗效。对MoCA、PSQI总分及分项评分与事件相关电位P300进行相关分析及线性回归分析。

结果：

治疗后，观察组患者MoCA注意力、抽象思维、延迟回忆分项评分与总分，以及WHOQOL-BREF评分均较治疗前升高（

0.05）；观察组患者MoCA语言能力、抽象思维、延迟回忆分项评分与总分，以及WHOQOL-BREF评分均高于对照组（

0.05）。观察组患者事件相关电位P300潜伏期较治疗前缩短（

0.05），振幅较治疗前增大（

0.05）；观察组患者事件相关电位P300潜伏期短于对照组（

0.05），振幅大于对照组（

0.05）。治疗后，观察组患者PSQI主观睡眠质量、睡眠潜伏期、睡眠效率、使用睡眠药物及白天功能紊乱分项评分与总分较治疗前降低（

0.05），对照组患者睡眠持续时间评分较治疗前降低（

0.05）；观察组患者主观睡眠质量、使用睡眠药物分项评分及总分低于对照组（

0.05）。观察组在认知功能、睡眠质量方面的总有效率均高于对照组[61.3%（19/31）

19.4%（6/31），80.6%（25/31）

19.4%（6/31)，

0.05

]

。MoCA总分与事件相关电位P300潜伏期呈负相关（

=-0.843，

0.001），与P300振幅呈正相关（

= 0.722，

0.001）；PSQI总分与事件相关电位P300潜伏期呈正相关（

=0.552，

0.001），与P300振幅呈负相关（

=-0.471，

0.001）。多元线性回归分析显示，P300潜伏期与抽象思维、延迟回忆、语言能力、命名、注意力、定向力呈线性关系，P300振幅与命名、抽象思维，延迟回忆、定向力呈线性关系；P300潜伏期、振幅与主观睡眠质量、使用睡眠药物呈线性关系。

结论：

壮医药线点灸疗法可以改善aMCI伴睡眠障碍患者认知功能，提升其睡眠及生活质量。

Abstract

Objective

To observe the clinical effect of medicated-thread moxibustion of Zhuang medicine on amnestic mild cognitive impairment (aMCI) with sleep disorder.

Methods

Sixty-four aMCI patients with sleep disorder were randomly divided into an observation group (32 cases

1 case withdrawn) and a control group (32 cases

1 case dropped out). Health education was performed in the control group. Besides the intervention as the control group

in the observation group

the medicated-thread moxibustion was delivered at Baihui (GV20) and Guanyuan (CV4)

as well as bilateral Zusanli (ST36) and Sanyinjiao (SP6). The treatment was given once every 2 days in the 1st month and twice a week in the 2nd and 3rd months; and the duration of treatment was composed of 30 sessions. Montreal cognitive assessment (MoCA)

Pittsburgh sleep quality index (PSQI)

and World Health Organization quality of life-BREF (WHOQOL-BREF) were scored before and after treatment in the two groups; and the latency and amplitude of event-related potential P300 were detected. The clinical therapeutic effects for the cognitive function and sleep quality were evaluated in the two groups. Correlation analysis and linear regression analysis were conducted on the event-related potential P300 related to the total scores of MoCA and PSQI as well as the scores of each subscale.

Results

After treatment

in the observation group

the scores on attention

abstraction

delayed recall and the total score of MoCA

as well as the score of WHOQOL-BREF were higher in comparison with those before treatment (

0.05). After treatment

the observation group showed the higher scores on language

abstraction

delayed recall

and the total score of MoCA

as well as the score of WHOQOL-BREF when compared with those in the control group (

0.05). After treatment

the latency of the event-related potential P300 was shortened (

0.05) and the amplitude was increased (

0.05) compared to those before treatment in the observation group; and the latency was shorter (

0.05)

and the amplitude was larger when compared with those in the control group (

0.05). After treatment

the score on subjective sleep quality

sleep latency

sleep efficiency

use of sleep medication and daytime dysfunction

and the total score of PSQI were lower than those before treatment in the observation group (

0.05); and the score on sleep duration was reduced in the control group (

0.05). After treatment

the scores on subjective sleep quality

use of sleep me

dication

and the total PSQI score in the observation group were lower when compared with those in the control group (

0.05). The total effective rates for the improvement in cognitive function and sleep quality in the observation group were higher than those in the control group

respectively (61.3% [19/31

]

19.4% [6/31

]

80.6% [25/31

]

19.4% [6/31

]

0.05). The total score of MoCA was negatively correlated with P300 latency (

=-0.843

0.001) and was positively correlated with P300 amplitude (

=0.722

0.001). The total score of PSQI was positively correlated with P300 latency (

=0.552

0.001) and was negatively correlated with P300 amplitude (

=-0.471

0.001). Multiple linear regression analysis indicated that P300 latency was linearly related to abstraction

delayed recall

language

naming

attention and orientation; P300 amplitude showed a linear relationship with naming

abstraction

delayed recall and orientation; and both latency and amplitude of P300 were linearly related to subjective sleep quality and use of sleep medication.

Conclusion

The medicated-thread moxibustion of Zhuang medicine ameliorates cognitive function and improves sleep and quality of life in aMCI patients combined with sleep disorder.

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