Study on nonlinear spatiotemporal response characteristics of acupoint electrical signals to multi-mode acupuncture and moxibustion stimulation based on array multichannel data

QI Shiyi; LIN Jinwen; WANG Shihao; CHEN Jianguo; LIN Lili; NI Youcong; DU Xin; LIN Dong

doi:10.13703/j.0255-2930.20250114-k0002

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Study on nonlinear spatiotemporal response characteristics of acupoint electrical signals to multi-mode acupuncture and moxibustion stimulation based on array multichannel data

Acupuncture and Intelligent Medicine | 更新时间：2025-09-12

- Study on nonlinear spatiotemporal response characteristics of acupoint electrical signals to multi-mode acupuncture and moxibustion stimulation based on array multichannel data
- Chinese Acupuncture & Moxibustion Vol. 45, Issue 9, Pages: 1209-1217(2025)
- 作者机构：
  
  福建中医药大学针灸推拿学院，福州　350122
  福州大学电气工程与自动化学院
  福建中医药大学附属第二人民医院
  福建师范大学计算机与网络空间安全学院
  福建中医药大学附属第三人民医院康复二科，福州　350122
- 作者简介：
- 基金信息：
- DOI：10.13703/j.0255-2930.20250114-k0002
  CLC：
- Received：14 January 2025，
  
  Online First：16 June 2025，
  
  Published：12 September 2025
- 稿件说明：
移动端阅览
QI Shiyi, LIN Jinwen, WANG Shihao, et al. Study on nonlinear spatiotemporal response characteristics of acupoint electrical signals to multi-mode acupuncture and moxibustion stimulation based on array multichannel data[J]. Chinese Acupuncture & Moxibustion, 2025, 45(9): 1209-1217.
DOI：

QI Shiyi, LIN Jinwen, WANG Shihao, et al. Study on nonlinear spatiotemporal response characteristics of acupoint electrical signals to multi-mode acupuncture and moxibustion stimulation based on array multichannel data[J]. Chinese Acupuncture & Moxibustion, 2025, 45(9): 1209-1217. DOI： 10.13703/j.0255-2930.20250114-k0002.

摘要

目的

通过提取阵列多通道数据的非线性特征参数，并结合多元统计分析，探索合谷穴不同刺激模式下远端皮肤电位在时空维度的变化规律。

方法

选取7名健康受试者，采用14×9阵列多通道电极采集左侧曲池穴体表电位。以左侧合谷穴作为刺激点，施加静息、点按、艾灸和行针4种模式，各模式采集电信号30 s，操作间隔5 min，采样频率为16 384 Hz。数据经集成经验模态分解（EEMD）降噪后，提取样本熵（SaEn）特征，并通过因子分析和多变量方差分析进行统计。

结果

点按、艾灸和行针模式下多数电极通道的SaEn值较静息状态增高。行针模式下电极通道的SaEn值在首个时间区间内（1－5 s）达到峰值，随后逐渐降低。因子分析显示，激活通道特异性集中于左侧曲池穴（载荷量≥0.90）；方差分析结果表明，激活通道的平均样本熵（

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https://html.publish.founderss.cn/rc-pub/api/common/picture?pictureId=89581327&type=

）值在合谷穴不同刺激模式差异有统计学意义（

0.001），但组别与时间区间的交互效应差异无统计学意义（

0.05）。

结论

通过非线性特征参数提取及多元统计分析，揭示了合谷穴在不同刺激模式下对远端皮肤电位的复杂时空变化规律，并成功识别出曲池穴的特异性激活特征。

Abstract

Objective

To elucidate the rules of temporal and spatial variations in distal skin potential at Hegu (LI4) under different stimulation modes by extracting nonlinear characteristic parameters from array multichannel data and adopting multivariate statistical analysis.

Methods

Seven healthy subjects were selected and the surface potential at the left Quchi (LI11) was collected using 14×9 array multichannel electrodes. Using Hegu (LI4) on the left as the stimulation point

four stimulation modes were applied

i.e. being quiescent

point pressing

moxibustion

and manual needling manipulation. Electrical signals were collected for 30 s in each mode

with a 5-min interval between operations

and a sampling frequency of 16 384 Hz. The data was denoised using ensemble empirical mode decomposition (EEMD)

and sample entropy (SaEn) features were extracted. Statistical analysis was conducted on these data using factor analysis and multivariate analysis of variance.

Results

The SaEn values of most electrode channels were higher under point pressing

moxibustion and manual needling manipulation compared with those under quiescent condition. Under manual needling manipulation

the SaEn value of the electrode channel reached the peak in the first time interval (1-5 s) and it was declining thereafter. Factor analysis showed that the specificity of activation channels was concentrated at the left Quchi (LI11) (loading capacity ≥0.90). Analysis of variance indicated that the significant differences were presented in average sample entropy (

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) values of activation channels among different stimulation modes at Hegu (LI4) (

0.001)

but there was no statistically significant interaction effect between groups and time intervals (

0.05).

Conclusion

Through nonlinear characteristic parameter extraction and multivariate statistical analysis

we have uncovered the complex temporal and spatial dynamical rules of distal skin potential at Hegu (LI4) under various stimulation modes and successfully identified the specific activation characteristics at Quchi (LI11).

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