Moxibustion combined with <italic style="font-style: italic">Jianpi Wenshen</italic> formula for cancer-related anorexia of spleen-kidney <italic style="font-style: italic">yang</italic> deficiency: a randomized controlled trial

YAN Minze; HE Shengqi; CHEN Dongxiao; WANG Yuechen; NIE Jing; GAO Yebo; MA Yinjie

doi:10.13703/j.0255-2930.20250705-0001

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Moxibustion combined with Jianpi Wenshen formula for cancer-related anorexia of spleen-kidney yang deficiency: a randomized controlled trial

Clinical Research | 更新时间：2026-09-15

- Moxibustion combined with Jianpi Wenshen formula for cancer-related anorexia of spleen-kidney yang deficiency: a randomized controlled trial
- Chinese Acupuncture & Moxibustion Vol. 46, Issue 9, Pages: 1421-1426(2026)
- 作者机构：
  
  中国中医科学院望京医院，肿瘤科，北京　100102
  中国中医科学院望京医院，针灸科，北京　100102
  中国中医科学院望京医院，风湿科，北京　100102
  长春中医药大学
- 作者简介：
- 基金信息：
- DOI：10.13703/j.0255-2930.20250705-0001
  CLC：
- Received：05 July 2025，
  
  Online First：08 July 2026，
  
  Published：12 September 2026
- 稿件说明：
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YAN Minze, HE Shengqi, CHEN Dongxiao, et al. Moxibustion combined with Jianpi Wenshen formula for cancer-related anorexia of spleen-kidney yang deficiency: a randomized controlled trial[J]. Chinese Acupuncture & Moxibustion, 2026, 46(9): 1421-1426. DOI: 10.13703/j.0255-2930.20250705-0001.
DOI：

YAN Minze, HE Shengqi, CHEN Dongxiao, et al. Moxibustion combined with Jianpi Wenshen formula for cancer-related anorexia of spleen-kidney yang deficiency: a randomized controlled trial[J]. Chinese Acupuncture & Moxibustion, 2026, 46(9): 1421-1426. DOI: 10.13703/j.0255-2930.20250705-0001. DOI：

摘要

目的：

观察艾灸联合健脾温肾方治疗脾肾阳虚型癌性厌食的临床疗效。

方法：

将80例脾肾阳虚型癌性厌食患者随机分为观察组和对照组，各40例。对照组给予健脾温肾方治疗；观察组在对照组基础上于双侧足三里、内关和中脘、关元、命门施艾灸治疗，前15 d每日1次，后改为隔日1次。两组均治疗4周。分别于治疗前后观察两组患者食欲、Karnofsky功能状态（KPS）、营养风险筛查2002（NRS-2002）、患者主观整体营养（PG-SGA）评分和血清干扰素-γ（IFN-γ）、C反应蛋白（CRP）含量，并于治疗后评定两组临床疗效。

结果：

治疗后，两组患者食欲、NRS-2002、PG-SGA评分和血清IFN-γ、CRP含量均较治疗前降低（

0.001，

0.05，

0.01），且观察组低于对照组（

0.05，

0.001）；两组患者KPS评分均较治疗前升高（

0.001，

0.05），且观察组高于对照组（

0.001）。观察组显效率为57.5%（23/40），高于对照组的30.0%（12/40，

0.05）。

结论：

艾灸联合健脾温肾方可有效改善脾肾阳虚型癌性厌食患者食欲和整体状态，降低血清IFN-γ、CRP含量。

Abstract

Objective

To observe the clinical efficacy of moxibustion combined with

Jianpi Wenshen

formula in treating cancer-related anorexia of spleen-kidney

yang

deficiency.

Methods

A total of 80 patients with cancer-related anorexia of spleen-kidney

yang

deficiency were randomized into an observation group and a control group

with 40 cases in each group.

Jianpi Wenshen

formula was given orally in the control group. On the basis of the treatment in the control group

moxibustion was applied at bilateral Zusanli (ST36)

Neiguan (PC6) and Zhongwan (CV12)

Guanyuan (CV4)

Mingmen (GV4) in the observation group

once daily for the first 15 days

then once every other day. Both groups were treated for 4 weeks. The scores of appetite

Karnofsky performance status (KPS)

nutritional risk screening 2002 (NRS-2002)

and patient-generated subjective global assessment (PG-SGA)

as well as the serum levels of interferon-γ (IFN-γ) and C-reactive protein (CRP)were observed before and after treatment

and the clinical efficacy was evaluated after treatment in the two groups.

Results

After treatment

the s

cores of appetite

NRS-2002

PG-SGA

and the serum levels of IFN-γ and CRP were decreased compared with those before treatment in the two groups (

0.001

0.05

0.01)

and the above indexes in the observation group were lower than those in the control group (

0.05

0.001); the KPS scores were increased in the two groups compared with those before treatment (

0.001

0.05)

and the KPS score in the observation group was higher than that in the control group (

0.001). The marked response rate was 57.5% (23/40) in the observation group

which was higher than 30.0% (12/40) in the control group (

0.05).

Conclusion

Moxibustion combined with

Jianpi Wenshen

formula can effectively improve appetite and overall status

and reduce the levels of IFN-γ and CRP in patients with cancer-related anorexia of spleen-kidney

yang

deficiency.

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⁰

Moxibustion combined with Jianpi Wenshen formula for cancer-related anorexia of spleen-kidney yang deficiency: a randomized controlled trial

DOI：10.13703/j.0255-2930.20250705-0001

摘要

Abstract

关键词

Keywords

references