Effects of <italic style="font-style: italic">ZHU Lian</italic>'s excitation-type acupuncture manipulation on limb function and serum oxidative stress indexes, angiogenic factors in patients with ischemic stroke during the recovery period

ZHAI Yang; GAO Yang; LI Fang; MO Zhizhen; HUANG Guike; WEI Yulu; CHI Tengfei; ZOU Min; PANG Yan; MEI Xiaoping; SHU Jianlong; WANG Han

doi:10.13703/j.0255-2930.20250718-0002

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Effects of ZHU Lian's excitation-type acupuncture manipulation on limb function and serum oxidative stress indexes, angiogenic factors in patients with ischemic stroke during the recovery period

Clinical Research | 更新时间：2026-06-24

- Effects of ZHU Lian's excitation-type acupuncture manipulation on limb function and serum oxidative stress indexes, angiogenic factors in patients with ischemic stroke during the recovery period
- Chinese Acupuncture & Moxibustion Vol. 46, Issue 6, Pages: 861-867(2026)
- 作者机构：
  
  南宁市第七人民医院/南宁市针灸研究所，脑病科，广西　南宁　530012
  南宁市第七人民医院/南宁市针灸研究所，针灸康复一区，广西　南宁　530012
  广西国际壮医医院/广西中医药大学附属国际壮医医院，儿科，
  广西国际壮医医院/广西中医药大学附属国际壮医医院，脑病科
  广西中医药大学第一附属医院仁爱分院
- 作者简介：
- 基金信息：
- DOI：10.13703/j.0255-2930.20250718-0002
  CLC：
- Received：18 July 2025，
  
  Online First：17 April 2026，
  
  Published：12 June 2026
- 稿件说明：
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ZHAI Yang, GAO Yang, LI Fang, et al. Effects of ZHU Lian's excitation-type acupuncture manipulation on limb function and serum oxidative stress indexes, angiogenic factors in patients with ischemic stroke during the recovery period[J]. Chinese Acupuncture & Moxibustion, 2026, 46(6): 861-867. DOI: 10.13703/j.0255-2930.20250718-0002.
DOI：

ZHAI Yang, GAO Yang, LI Fang, et al. Effects of ZHU Lian's excitation-type acupuncture manipulation on limb function and serum oxidative stress indexes, angiogenic factors in patients with ischemic stroke during the recovery period[J]. Chinese Acupuncture & Moxibustion, 2026, 46(6): 861-867. DOI: 10.13703/j.0255-2930.20250718-0002. DOI：

摘要

目的：

观察朱琏针灸兴奋法对缺血性脑卒中恢复期患者肢体功能及血清氧化应激指标、血管生成因子的影响。

方法：

将84例缺血性脑卒中恢复期患者随机分为朱琏针灸组（42例，脱落5例）和常规针刺组（42例，脱落8例）。在常规治疗基础上，朱琏针灸组予朱琏针灸兴奋法治疗，常规针刺组予常规针刺治疗，均穴取患侧风池、肩髃、曲池、外关、新设、肩髎、新义、合谷等。均每日1次，共治疗3周。观察两组患者治疗前后Fugl-Meyer运动功能评定量表（FMA）、Berg平衡量表（BBS）、改良Barthel指数（MBI）评分和血清超氧化物歧化酶（SOD）、丙二醛（MDA）、还原型谷胱甘肽（GSH）、血管内皮生长因子（VEGF）、碱性成纤维细胞生长因子（bFGF）、内皮素-1（ET-1）含量。

结果：

与治疗前比较，两组患者治疗后FMA、BBS、MBI评分及血清SOD、GSH、VEGF、bFGF含量均升高（

0.001，

0.05，

0.01），血清MDA、ET-1含量降低（

0.001）；治疗后，朱琏针灸组患者FMA、BBS、MBI 评分及血清SOD、GSH、VEGF、bFGF含量均高于常规针刺组（

0.05，

0.001），血清MDA、ET-1含量低于常规针刺组（

0.001，

0.01）。

结论：

朱琏针灸兴奋法可能通过调节缺血性脑卒中恢复期患者抗氧化能力和血管生成发挥神经保护效应，从而改善患者肢体功能。

Abstract

Objective

To observe the effects of

ZHU Lian

's excitation-type acupuncture manipulation on limb function and serum oxidative stress indexes

and angiogenic factors in patients with ischemic stroke during the recovery period.

Methods

A total of 84 patients with ischemic stroke during the recovery period were randomly divided into a ZHU Lian acupuncture group (42 cases

5 cases dropped out) and a conventional acupuncture group (42 cases

8 cases dropped out). On the basis of routine treatment

the ZHU Lian acupuncture group received

ZHU Lian

's excitation-type acupuncture manipulation

while the conventional acupuncture group received conventional acupuncture treatment. Acupoints on the affected side were selected

including Fengchi (GB20)

Jianyu (LI15)

Quchi (LI11)

Waiguan (TE5)

Xinshe (Extra)

Jianliao(TE14)

Xinyi (Extra)

Hegu (LI4)

etc. Treatments were administered once daily for 3 weeks in both groups. The Fu

gl-Meyer assessment (FMA)

Berg balance scale (BBS)

modified Barthel index (MBI) scores and serum levels of superoxide dismutase(SOD)

malondialdehyde (MDA)

reduced glutathione (GSH)

vascular endothelial growth factor (VEGF)

basic fibroblast growth factor (bFGF)

endothelin-1 (ET-1) were observed before and after treatment in both groups.

Results

Compared with before treatment

the FMA

BBS

MBI scores and serum levels of SOD

GSH

VEGF

bFGF after treatment were increased in both groups (

0.001

0.05

0.01)

and serum levels of MDA and ET-1 were decreased (

0.001); after treatment

the FMA

BBS

MBI scores and serum levels of SOD

GSH

VEGF

bFGF in the ZHU Lian acupuncture group were higher than those in the conventional acupuncture group (

0.05

0.001)

and serum levels of MDA and ET-1 in the ZHU Lian acupuncture group were lower than those in the conventional acupuncture group (

0.001

0.01).

Conclusion

ZHU Lian

's excitation-type acupuncture manipulation may exert neuroprotective effects in patients with ischemic stroke during the recovery period by modulating antioxidant capacity and angiogenesis

thereby improving limb function.

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Effects of ZHU Lian's excitation-type acupuncture manipulation on limb function and serum oxidative stress indexes, angiogenic factors in patients with ischemic stroke during the recovery period

DOI：10.13703/j.0255-2930.20250718-0002

摘要

Abstract

关键词

Keywords

references