Effects of electroacupuncture on gastrointestinal dysfunction and serum metabolites in postoperative patients with gastric cancer

LI Li; SUN Jianhua; GUO Jing; YU Zhongxu; MIAO Qingyun; HU Linyan; WANG Kesha; CHEN Lu

doi:10.13703/j.0255-2930.20250805-0002

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Effects of electroacupuncture on gastrointestinal dysfunction and serum metabolites in postoperative patients with gastric cancer

Clinical Research | 更新时间：2026-04-16

- Effects of electroacupuncture on gastrointestinal dysfunction and serum metabolites in postoperative patients with gastric cancer
- Chinese Acupuncture & Moxibustion Vol. 46, Issue 4, Pages: 537-546(2026)
- 作者机构：
  
  南京中医药大学附属医院针灸康复科，江苏南京　210029
  江苏省中医院针灸康复科，南京　210029
  南京中医药大学针灸推拿学院·养生康复学院
- 作者简介：
- 基金信息：
- DOI：10.13703/j.0255-2930.20250805-0002
  CLC：
- Received：05 August 2025，
  
  Online First：13 February 2026，
  
  Published：12 April 2026
- 稿件说明：
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LI Li, SUN Jianhua, GUO Jing, et al. Effects of electroacupuncture on gastrointestinal dysfunction and serum metabolites in postoperative patients with gastric cancer[J]. Chinese Acupuncture & Moxibustion, 2026, 46(4): 537-546.
DOI：

LI Li, SUN Jianhua, GUO Jing, et al. Effects of electroacupuncture on gastrointestinal dysfunction and serum metabolites in postoperative patients with gastric cancer[J]. Chinese Acupuncture & Moxibustion, 2026, 46(4): 537-546. DOI： 10.13703/j.0255-2930.20250805-0002.

摘要

目的：

观察电针对胃癌术后患者胃肠功能恢复的促进作用，采用代谢组学技术探讨电针调节胃肠动力的可能生物学机制。

方法：

将60例接受腹腔镜胃癌根治术的患者随机分为试验组和对照组，各30例；同时招募20例健康受试者作为健康组。对照组患者接受规范化围手术期管理方案；在对照组基础上，试验组于术后麻醉苏醒后2、24、48、72 h予针刺双侧足三里、上巨虚及内关，同侧足三里与上巨虚连接电针，连续波，频率50 Hz，电流0.1~1 mA，每次30 min。治疗后观察两组患者术后胃肠功能相关指标（首次肛门排气时间、首次肛门排便时间、首次经口进水时间及首次行走时间）；于术前、术后2 h及术后72 h观察两组患者疼痛视觉模拟量表（VAS）评分；采用血清代谢组学分析筛选与电针促进胃肠功能恢复相关的特征性代谢标志物。

结果：

试验组患者术后首次肛门排气时间、首次肛门排便时间、首次经口进水时间及首次行走时间均早于对照组（

0.05），术后72 h疼痛VAS评分低于对照组（

0.05）。通过血清代谢组学分析，共确定1-甲基鸟嘌呤（1-Methylguanine）、（2-氨基乙氧基）乙酸[2-（2-Aminoethoxy）acetic acid

]

等10个电针缓解胃癌术后胃肠功能障碍的特征代谢标志物。

结论：

电针可促进胃癌术后胃肠功能恢复，其内在机制可能与减轻炎症反应、改善肠道微生物群落结构和稳定肠道屏障功能相关。

Abstract

Objective

To observe the promoting effect of electroacupuncture (EA) on gastrointestinal function recovery in patients after gastric cancer operation

and to explore the possible biological mechanisms by which EA regulates gastrointestinal motility using metabolomics.

Methods

A total of 60 patients who underwent laparoscopic radical gastrectomy were randomly divided into a treatment group and a control group

30 cases in each group. An additional 20 healthy individuals were recruited as the healthy group. The patients in the control group received standardized perioperative care. In addition

the patients in the treatment group received acupuncture at bilateral Zusanli (ST36)

Shangjuxu (ST37)

and Neiguan (PC6) at 2

and 72 hours post-anesthesia recovery. EA was applied between ipsilateral Zusanli (ST36) and Shangjuxu (ST37) using continuous waves at 50 Hz of frequency and 0.1-1 mA intensity for 30 minutes per session. Postoperative gastrointestinal function indexes were observed

including time to first anal exhaust

time to first anal defecation

time to first oral fluid intake

and time to first ambulation. Pain visual analogue scale (VAS) scores were recorded at pre-operation

2 hours post-operation

and 72 hours post-operation. Serum metabolomics analysis was conducted to identify characteristic metabolites associated with the EA-induced promotion of gastrointestinal recovery.

Results

Compared with the control group

the treatment group showed significantly earlier time to first anal exhaust

time to first anal defecation

time to first oral fluid intake

and time to first ambulation (

0.05). Compared with the control group

the pain VAS score at 72 hours post-operation was significantly lower in the treatment group (

0.05). Through serum metabolomics analysis

a total of 10 characteristic metabolic biomarkers associated with EA in alleviating postoperative gastrointestinal dysfunction after gastric cancer operation were identified

including 1-Methylguanine and (2-Aminoethoxy) acetic acid.

Conclusion

EA can promote postoperative gastrointestinal function recovery in postoperative patients with gastric cancer. The underlying mechanism may be related to alleviation of inflammatory responses

improvement of gut microbiota composition

and stabilization of intestinal barrier function.

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