Electroacupuncture combined with western medication for non-erosive reflux disease: a randomized controlled trial

GU Xiyan; CHEN Guisheng; SHI Dazhong; FENG Yulu; MA Yitong; CHEN Zhaoming; LU Wen; XIA Xiaofang; ZHOU Zhi; ZHANG Jianbin

doi:10.13703/j.0255-2930.20250915-k0003

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Electroacupuncture combined with western medication for non-erosive reflux disease: a randomized controlled trial

Clinical Research | 更新时间：2026-05-12

- Electroacupuncture combined with western medication for non-erosive reflux disease: a randomized controlled trial
- Chinese Acupuncture & Moxibustion Vol. 46, Issue 5, Pages: 725-731(2026)
- 作者机构：
  
  南京中医药大学，江苏　南京　210023
  南通市第三人民医院针灸科
  黑龙江中医药大学
  南京市中医院针灸科，江苏　南京　210006
  连云港市第一人民医院针灸科
  南京市高淳中医院针灸康复科
  南京市鼓楼区江东社区卫生服务中心针灸推拿科
  江苏省第二中医院针灸科
- 作者简介：
- 基金信息：
- DOI：10.13703/j.0255-2930.20250915-k0003
  CLC：
- Received：15 September 2025，
  
  Online First：06 February 2026，
  
  Published：12 May 2026
- 稿件说明：
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GU Xiyan, CHEN Guisheng, SHI Dazhong, et al. Electroacupuncture combined with western medication for non-erosive reflux disease: a randomized controlled trial[J]. Chinese Acupuncture & Moxibustion, 2026, 46(5): 725-731.
DOI：

GU Xiyan, CHEN Guisheng, SHI Dazhong, et al. Electroacupuncture combined with western medication for non-erosive reflux disease: a randomized controlled trial[J]. Chinese Acupuncture & Moxibustion, 2026, 46(5): 725-731. DOI： 10.13703/j.0255-2930.20250915-k0003.

摘要

目的：

比较电针联合雷贝拉唑钠肠溶胶囊、假电针联合雷贝拉唑钠肠溶胶囊与单纯雷贝拉唑钠肠溶胶囊治疗非糜烂性反流病（NERD）的临床疗效。

方法：

将156例NERD患者按1∶1∶1的比例随机分为电针组（52例，脱落2例）、假电针组（52例，脱落2例）、西药组（52例，脱落2例）。西药组予雷贝拉唑钠肠溶胶囊口服，每次20 mg，每日1次，共治疗8周。电针组在西药组治疗基础上加电针治疗，穴取督脉阳性反应点、大椎和百会等，使用频率为10 Hz的连续波，电流2~5 mA，留针30 min，隔日1次，每周3次，共治疗8周。假电针组取穴、操作与电针组相同，但不予电流刺激。观察各组患者治疗前后及治疗结束后3个月随访时反流性疾病问卷（RDQ）评分、焦虑自评量表（SAS）评分及抑郁自评量表（SDS）评分，并评定各组临床疗效。

结果：

治疗后及随访时，各组患者RDQ评分、SDS评分均较治疗前降低（

0.05）；电针组患者RDQ评分、SDS评分均低于假电针组和西药组（

0.05），假电针组患者RDQ评分、SDS评分均低于西药组（

0.05）。各组患者治疗后SAS评分均较治疗前降低（

0.05），电针组和假电针组患者随访时SAS评分均较治疗前降低（

0.05）；电针组患者治疗后及随访时SAS评分均低于假电针组和西药组（

0.05），假电针组患者治疗后及随访时SAS评分均低于西药组（

0.05）。电针组总有效率为96.0%（48/50），高于假电针组（92.0%，46/50）和西药组（86.0%，43/50，

0.05）；假电针组总有效率高于西药组（

0.05）。

结论：

电针联合雷贝拉唑钠肠溶胶囊可有效改善NERD患者的临床症状及情绪障碍，并具有持续效应，疗效优于假电针联合雷贝拉唑钠肠溶胶囊及单纯雷贝拉唑钠肠溶胶囊。

Abstract

Objective

To compare the clinical efficacy on non-erosive reflux disease (NERD) among electroacupuncture (EA) combined with rabeprazole sodium enteric-coated capsules

sham-EA combined with rabeprazole sodium enteric-coated capsules

and rabeprazole sodium enteric-coated capsules alone.

Methods

A total of 156 patients with NERD were randomly assigned

at 1∶1∶1

into an EA group (52 cases

2 cases dropped out)

a sham-EA group (52 cases

2 cases dropped out)

and a western medication group (52 cases

2 cases dropped out). In the western medication group

rabeprazole sodium enteric-coated capsules were administered orally

20 mg

once daily and for 8 weeks. In the EA group

besides the medication as the western medication group

EA was operated at the positive reaction points along the governor vessel

Dazhui (GV14) and Baihui (GV20)

etc.

with continuous wave and at the frequency of 10 Hz and an electric intensity of 2-5 mA. EA was delivered once every 2 days

3 sessions a week and for 8 weeks. In the sham-EA group

the stimulating point selection and EA operation were the same as the EA group

but without electric stimulation exerted. The scores of reflux disease questionnaire (RDQ)

self-rating anxiety scale (SAS)

and self-rating depression scale (SDS) were assessed before and after treatment

as well as in the 3-month follow-up; and the clinical efficacy was evaluated in each group.

Results

After treatment and in the 3-month follow-up

the scores of RDQ and SDS were reduced in each group (

0.05); the EA group showed the lower scores of RDQ and SDS when compared with those in the sham-EA group and the western medication group (

0.05)

and the scores of RDQ and SDS in the sham-EA group were lower than those of the western medication group (

0.05). The SAS score was lower after treatment in comparison with that before treatment in each group (

0.05)

and the score in both the EA group and the sham-EA group was reduced in follow-up (

0.05). After treatment and in follow-up

SAS scores in the EA group were lower than those in the sham-EA group and the western medication group

respectively (

0.05)

and the scores in the sham-EA group were lower when compared with those in the western medication group (

0.05). The total effective rate in the EA group was 96.0% (48/50)

higher than that in the sham-EA group (92.0%

46/50) and the western medication group (86.0%

43/50

0.05); and the total effective rate in the sham-EA group was higher than that in the western medication group (

0.05).

Conclusion

Electroacupuncture combined with rabeprazole sodium enteric-coated capsules effectively alleviates clinical symptoms and emotional disorders in patients with NERD

presenting sustained therapeutic effect; and its efficacy is superior to the combined regimen of sham-EA and rabeprazole sodium enteric-coated capsules or the administration with rabeprazole sodium enteric-coated capsules alone.

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