Multidimensional effect of acupuncture bloodletting technique at hand twelve <italic style="font-style: italic">jing</italic>-well points on the functions of thalamus and related cortical regions

ZHAO Jiayue; CHAI Chao; YAO Ganglin; GUO Yi; ZHAO Yadan; ZHANG Zichen; YANG Yuanzhen; LUO Yu; MIAO Shiyu; ZHANG Chaoyang; HUANG Jing; XU Zhifang

doi:10.13703/j.0255-2930.20250924-k0003

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Multidimensional effect of acupuncture bloodletting technique at hand twelve jing-well points on the functions of thalamus and related cortical regions

Clinical Research | 更新时间：2026-04-16

- Multidimensional effect of acupuncture bloodletting technique at hand twelve jing-well points on the functions of thalamus and related cortical regions
- Chinese Acupuncture & Moxibustion Vol. 46, Issue 4, Pages: 500-506(2026)
- 作者机构：
  
  天津中医药大学实验针灸学研究中心，天津　301617
  天津中医药大学针灸推拿学院，天津　301617
  天津市第一中心医院放射科
  大连市中医医院
  国家中医针灸临床医学研究中心，天津　300193
  天津市现代中医理论创新转化重点实验室，天津　301617
  青岛市中医医院/青岛大学附属青岛市海慈医院
- 作者简介：
- 基金信息：
- DOI：10.13703/j.0255-2930.20250924-k0003
  CLC：
- Received：24 September 2025，
  
  Online First：29 January 2026，
  
  Published：12 April 2026
- 稿件说明：
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ZHAO Jiayue, CHAI Chao, YAO Ganglin, et al. Multidimensional effect of acupuncture bloodletting technique at hand twelve jing-well points on the functions of thalamus and related cortical regions[J]. Chinese Acupuncture & Moxibustion, 2026, 46(4): 500-506. DOI: 10.13703/j.0255-2930.20250924-k0003.
DOI：

ZHAO Jiayue, CHAI Chao, YAO Ganglin, et al. Multidimensional effect of acupuncture bloodletting technique at hand twelve jing-well points on the functions of thalamus and related cortical regions[J]. Chinese Acupuncture & Moxibustion, 2026, 46(4): 500-506. DOI: 10.13703/j.0255-2930.20250924-k0003. DOI：

摘要

目的：

基于静息态功能性磁共振成像（rs-fMRI）技术，探讨手井穴刺络放血对健康受试者丘脑-皮层网络功能的调控作用，从多维度脑功能指标分析其改善脑功能状态、促进脑保护的潜在神经机制。

方法：

采用自身前后对照设计，纳入30名健康受试者，完成rs-fMRI扫描后在操作床上接受手井穴刺络放血（按右手→左手、拇指→小指顺序依次对少商、商阳、中冲、关冲、少冲、少泽刺络放血），干预完成后继续进行rs-fMRI扫描。分析干预前后健康受试者大脑低频波动振幅（ALFF）和局部一致性（ReHo）、以丘脑为种子点的全脑功能连接（FC）、脑血流量。

结果：

与干预前比较，健康受试者干预后双侧颞上回、双侧颞中回、双侧楔前叶及双侧丘脑ALFF降低（

0.05），双侧颞上回、双侧颞中回、双侧丘脑ReHo降低（

0.05）。与干预前比较，健康受试者干预后左侧丘脑与双侧舌回、双侧距状裂周围皮层、左侧枕上回、左侧梭状回、双侧中央前回、右侧中央沟盖以及双侧颞中回的FC增强（

0.05），与左侧楔前叶的FC减弱（

0.05）；右侧丘脑与双侧舌回、双侧距状裂周围皮层、双侧枕中回、双侧梭状回、双侧枕上回、双侧颞下回、双侧楔叶、双侧中央前回、双侧中央沟盖、左侧颞上回、左侧三角部额下回的FC增强（

0.05）。健康受试者脑血流量干预前后比较差异无统计学意义（

0.05）。

结论：

手井穴刺络放血可调节大脑功能状态，一方面抑制丘脑及高阶皮层节点的过度活跃与异常同步放电，另一方面重塑丘脑功能连接网络。

Abstract

Objective

To investigate the regulatory effect of acupuncture bloodletting technique at hand twelve

jing

-well points on the thalamus-cortex network function in healthy subjects using resting-state functional magnetic resonance imaging (rs-fMRI)

so as to analyze the underlying neural mechanism for improving brain functions and promoting brain protection based on multi-dimensional brain function indexes.

Methods

A within-subject controlled design was employed

involving 30 healthy subjects. After rs-fMRI scanning

the subjects received acupuncture bloodletting technique at hand twelve

jing

-well points

stimulated from the right hands to the left hands

from the thumb to the small finger

sequentially at Shaoshang(LU11)

Shangyang (LI1)

Zhongchong (PC9)

Guanchong (TE1)

Shaochong (HT9) and Shaoze (SI1). After intervention completion

the rs-fMRI scanning was operated again. The amplitude of low-frequency fluctuations (ALFF)

regional homogeneity (ReHo)

and whole-brain functional connectivity (FC) with the thalamus as the region of interest

as well as cerebral blood flow (CBF) were analyzed before and after intervention in healthy subjects.

Results

In comparison with the indexes before intervention

ALFF decreased in the bilateral superior temporal gyrus

middle temporal gyrus

precuneus and thalamus after intervention (

0.05); and ReHo was reduced in the bilateral superior temporal gyrus

middle temporal gyrus and thalamus (

0.05). In comparison with the indexes before intervention

after intervention

FC of the left thalamus was enhanced with bilateral lingual gyrus

bilateral pericalcarine cortex

left superior occipital gy

rus

left fusiform gyrus

bilateral central anterior gyrus

right central sulcus

and bilateral middle temporal gyrus (

0.05)

and it was weakened with the left precuneus (

0.05); and the enhanced FC of the right thalamus was observed with the bilateral lingual gyrus

bilateral pericalcarine cortex

bilateral middle occipital gyrus

bilateral fusiform gyrus

bilateral superior occipital gyrus

bilateral inferior temporal gyrus

bilateral cuneus

bilateral precentral gyrus

bilateral central sulcus

left superior temporal gyrus

and left inferior frontal triangular gyrus (

0.05). There was no statistical significance of difference in CBF before and after intervention (

0.05).

Conclusion

Acupuncture bloodletting technique at hand twelve

jing

-well points may regulate the functional state of the brain by means of inhibiting the excessive activity and abnormal synchronous discharges in the thalamus and higher-order cortical nodes and through reconstructing the functional connection network of the thalamus.

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Related Institution

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Multidimensional effect of acupuncture bloodletting technique at hand twelve jing-well points on the functions of thalamus and related cortical regions

DOI：10.13703/j.0255-2930.20250924-k0003

摘要

Abstract

关键词

Keywords

references