Heat-sensitive moxibustion alleviates psychological craving in patients with methamphetamine addiction (withdrawal stage): a randomized controlled trial

LI Haiyan; CHEN Rixin; HE Wei; ZOU Chunliang; XIE Dingyi

doi:10.13703/j.0255-2930.20251009-k0001

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Heat-sensitive moxibustion alleviates psychological craving in patients with methamphetamine addiction (withdrawal stage): a randomized controlled trial

Clinical Research | 更新时间：2026-04-16

- Heat-sensitive moxibustion alleviates psychological craving in patients with methamphetamine addiction (withdrawal stage): a randomized controlled trial
- Chinese Acupuncture & Moxibustion Vol. 46, Issue 4, Pages: 507-516(2026)
- 作者机构：
  
  江西中医药大学热敏灸转化医学研究中心，南昌　330004
  江西中医药大学附属医院针灸科，南昌　330025
  江西省戒毒管理局
  江西省女子强制隔离戒毒所
- 作者简介：
- 基金信息：
- DOI：10.13703/j.0255-2930.20251009-k0001
  CLC：
- Received：09 October 2025，
  
  Online First：13 February 2026，
  
  Published：12 April 2026
- 稿件说明：
移动端阅览
LI Haiyan, CHEN Rixin, HE Wei, et al. Heat-sensitive moxibustion alleviates psychological craving in patients with methamphetamine addiction (withdrawal stage): a randomized controlled trial[J]. Chinese Acupuncture & Moxibustion, 2026, 46(4): 507-516.
DOI：

LI Haiyan, CHEN Rixin, HE Wei, et al. Heat-sensitive moxibustion alleviates psychological craving in patients with methamphetamine addiction (withdrawal stage): a randomized controlled trial[J]. Chinese Acupuncture & Moxibustion, 2026, 46(4): 507-516. DOI： 10.13703/j.0255-2930.20251009-k0001.

摘要

目的：

观察热敏灸对甲基苯丙胺成瘾者（戒断期）心理渴求的影响。

方法：

将60例甲基苯丙胺成瘾者（戒断期）随机分为观察组和对照组，各30例。对照组接受戒毒所内常规戒毒矫正教育；观察组在对照组基础上于神阙、膻中进行热敏灸治疗，每次60 min，每天1次，每周4次，两组均治疗4周。于治疗前、治疗4周后及治疗结束后2周（随访）观察两组受试者心理渴求视觉模拟量表（VAS）评分，于治疗前后采用近红外脑功能成像（fNIRS）技术观察两组受试者脑区激活及脑功能连接度变化。

结果：

治疗4周后及随访时，观察组受试者心理渴求VAS评分较治疗前降低（

0.01），且低于对照组（

0.01）。治疗4周后，观察组受试者药物刺激下左侧额下回（L-IFG）、左侧额极区（L-FPA）、左侧背外侧前额叶（L-DLPFC）激活较治疗前及对照组减弱（

0.01，

0.05）。治疗4周后，观察组受试者右侧额下回（R-IFG）与左侧前运动皮层和辅助运动皮层（L-PM

SMA）、左侧体感皮层（L-S1）、右侧韦尼克区（R-Wernicke）脑区，右侧布洛卡区（R-Broca）与右侧体感皮层（R-S1）、L-S1脑区功能连接度增强（

0.05，

0.01），对照组受试者L-FPA与右侧前运动皮层和辅助运动皮层（R-PM

SMA）脑区功能连接度增强（

0.05）；观察组受试者R-IFG与L-PM

SMA、L-S1、R-Wernicke脑区功能连接度较对照组增强（

0.05，

0.01）。

结论：

热敏灸可减轻甲基苯丙胺成瘾者（戒断期）的心理渴求，其机制可能涉及多个脑区的复杂调节。

Abstract

Objective

To observe the effect of heat-sensitive moxibustion on psychological craving in patients with methamphetamine addiction (withdrawal stage).

Methods

Sixty patients with methamphetamine addiction (withdrawal stage) were randomly divided into an observation group and a control group

with 30 cases in each group. The control group received routine drug rehabilitation and correctional education in the rehabilitation center; the observation group received heat-sensitive moxibustion at Shenque (CV8) and Danzhong (CV17) on the basis of the control group regimen

60 min per session

once daily

four times a week. Both groups were treated for 4 weeks. The visual analogue scale (VAS) score for psychological craving was assessed before treatment

4 weeks into treatment

and 2 weeks after treatment completion (follow-up) in the two groups. Functional near-infrared spectroscopy (fNIRS) was used to observe the brain region activation and brain functional connectivity changes before and after treatment in the two groups.

Results

Compared before treatment

the VAS scores for psychological craving were reduced at 4 weeks into treatment and at follow-up in the observation group (

0.01)

which were lower than those in the control group (

0.01). Compared before treatment and the control group

the brain activation in the left inferior frontal gyrus (L-IFG)

left frontopolar area (L-FPA)

and left dorsolateral prefrontal cortex (L-DLPFC) was decreased in the observation group (

0.01

0.05). Compared before treatment

the functional connectivity was enhanced between the right inferio

r frontal gyrus (R-IFG) and left premotor

supplementary motor cortex (L-PM

SMA)

left somatosensory cortex (L-S1)

right Wernicke (R-Wernicke)

as well as the right Brocaʹs area and right somatosensory cortex (R-S1)

L-S1 in the observation group after treatment (

0.05

0.01). Compared before treatment

the functional connectivity was enhanced between L-FPA and right PM

SMA in the control group after treatment (

0.05). Compared with the control group

the observation group showed stronger enhancements in functional connectivity of R-IFG with L-PM

SMA

L-S1

and R-Wernicke after treatment (

0.05

0.01).

Conclusion

Heat-sensitive moxibustion could alleviate psychological craving in patients with methamphetamine addiction (withdrawal stage)

possibly through complex regulatory mechanisms involving multiple brain regions.

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