Objective To observe the clinical effect of Panlong（dragon-like） acupuncture combined with Xingnao Kaiqiao（regaining consciousness and opening orifice） acupuncture on post-stroke fatigue. Methods Sixty patients with post-stroke fatigue were randomly divided into an observation group（30 cases

1 case dropped off） and a control group（30 cases

2 cases dropped off）. The patients in the control group were treated with Xingnao Kaiqiao acupuncture at Neiguan（PC 6）

Shuigou（GV 26）

etc. for 30 min; based on the treatment of the control group

the patients in the observation group were treated with Panlong acupuncture at Jiaji（EX-B 2） of T1 to L5 for 15 min. The two groups were treated once a day

6 times a week

for a total of 4 weeks. The scores of fatigue assessment instrument（FAI）

energy of stroke-specific quality of life（SS-QOL）

and modified Barthel index（MBI） in the two groups were compared before and after treatment

and the clinical efficacy was evaluated. Results Compared before treatment

the total score and each item score of FAI in the observation group were reduced after treatment（P<0.05）

while the total score and FAI-1 and FAI-4 scores in the control group were reduced after treatment（P<0.05）. The total score of FAI and FAI-1

FAI-2 and FAI-4 scores in the observation group were lower than those in the control group（P<0.05）. After treatment

the SS-QOL energy scores and MBI scores of the two groups were increased compared before treatment（P<0.05）

and the SS-QOL energy score in the observation group was higher than that in the control group（P<0.01）. The total effective rate was 72.4%（21/29） in the observation group

which was better than 46.4%（13/28） in the control group（P<0.05）. Conclusion The Panlong acupuncture combined with Xingnao Kaiqiao acupuncture could effectively alleviate the fatigue symptoms and improve quality of life in patients with post-stroke fatigue.