Objective To assess the effect of Xingnao Kaiqiao（regaining consciousness and opening orifices）acupuncture on the efficacy and safety of intravenous thrombolysis with recombinant tissue plasminogen activator（rt-PA） in patients with cerebral infarction.Methods A total number of 142 patients of cerebral infarction undergoing rt-PA intravenous thrombolysis were randomized into an acupuncture-medication group（71 cases） and a western medication group（71 cases

1 case dropped off）.In the western medication group

rt-PA intravenous thrombolysis was given.In the acupuncture-medication group

besides the intervention as the control group

Xingnao Kaiqiao acupuncture was provided at Shuigou（GV 26）

Neiguan（PC 6）

Sanyinjiao（SP 6）

Jiquan（HT 1）

etc.once daily.One treatment session contained 6treatments and 1 session was required.Before and after treatment

the score of the National Institute of Health stroke scale（NIHSS）

the levels of the relevant indexes of symptomatic intracerebral hemorrhage（sICH）（platelet [PLT]

D-dimer and fibrinogen）

the incidences of sICH and adverse effect were compared between groups.The efficacy was assessed in two groups.Results After treatment

NIHSS scores and the levels of D-dimer were reduced compared with those before treatment in both groups（P<0.05）

and those in the acupuncture-medication group were lower than the western medication group（P<0.05）.The level of fibrinogen in the acupuncture-medication group was increased in comparison with that before treatment（P<0.05）

and also higher than the western medication group（P<0.05）.The incidence of sICH was 0%（0/71） in the acupuncture-medication group

lower than 8.6%（6/70） in the western medication group（P<0.05）.The effective rate was 97.2%（69/71） in the acupuncture-medication group

higher than 87.1%（61/70） in the western medication group（P<0.05）.The incidence of adverse effect was 2.8%（2/71） in the acupuncture-medication group

lower than 12.9%（9/70） in the western medication group（P<0.05）.Conclusion Xingnao Kaiqiao acupuncture may improve the efficacy of rt-PA intravenous thrombolysis in the patients with cerebral infraction and decrease the incidences of s ICH and adverse effect.The mechanism may be related to the regulation of fibrinogen and D-dimer levels.