Acupoint is the initial response site of acupuncture stimulus and also the source link of the effect onset of acupuncture. Acupuncture is a mechanical physical stimulus. How is the mechanical force of acupuncture transduced into neuroelectrical and biochemical signals at acupoint? How does the physiochemical information of acupoint launch acupuncture effect? All of these remain the common and crucial questions in the study of acupuncture effect mechanism.Physical changes are induced in the local tissue of acupoint by needling techniques

such as the deformation and displacement of muscle fibers

which may act on the nerve ending receptors and produce electroneurographic signals.Besides

these changes may activate the mechanosensitive ion channels of the cytomembrane in acupoint site. Through cellular signal transduction

the physical signals may be transformed into chemical ones to trigger the physiochemical coupling response of acupoint microenvironment. Eventually

acupuncture effect is generated via nerves and body fluids. "The mechanical force of acupuncture"

through "the physiochemical transduction"

promotes the body’s perception and transmits acupuncture signals. It suggests that acupoint is the "transducer" in the physiochemical information coupling response of acupuncture.