This paper summarizes professor GUAN Ling’s clinical experience in the treatment of knee osteoarthritis（KOA） with structure-based medical acupuncture（SMA）. Based on anatomy and biomechanics and through accurate physical examination

SMA adjusts the mechanical imbalance of muscles to relieve KOA dysfunction

and releases nerve compression to attenuate pain symptoms of KOA. In reference to traditional acupoint selection

and in association with painful areas and mechanical deduction

ashi points located at the rectus femoris

vastus intermedius

vastus medialis and vastus lateralis muscles

etc. are specially stimulated with acupuncture; and the rehabilitation training and health education are the adjuvant treatment for the patients.