功能磁共振研究元分析方法介绍及其在针刺领域的应用探析

葛文逸; 刘巍; 樊小农; 李仪丙; 贾鸿博; 雷康辰; 李宋姣; 常颖慧

doi:10.13703/j.0255-2930.20230627-k0003

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功能磁共振研究元分析方法介绍及其在针刺领域的应用探析

针灸影像临床与基础 | 更新时间：2024-06-03

- 功能磁共振研究元分析方法介绍及其在针刺领域的应用探析
- Introduction to the Meta-analysis method of functional magnetic resonance imaging research and the exploration of its application in the field of acupuncture
- 中国针灸 2024年44卷第1期页码：25-33
- 作者机构：
  
  1.天津中医药大学第一附属医院，天津300193
  2.国家中医针灸临床医学研究中心，天津300193
  3.天津市针灸研究所，天津300193
  4.天津市针灸学重点实验室，天津300193
  5.国家中医药管理局针刺量效关系实验室（三级），天津300193
- 作者简介：
  
  葛文逸，天津中医药大学博士研究生。E-mail： gewenyi@yeah.net
  樊小农，主任医师。E-mail：fanxiaonong@163.com
- 基金信息：
  
  国家自然科学基金资助项目(82374578);国家重点研发计划项目(2018YFC1705004);天津市科技计划项目(21JCZDJC00890);天津市教委科研计划项目(2021ZD011)
- DOI：10.13703/j.0255-2930.20230627-k0003
  中图分类号：
- 收稿：2023-06-27，
  
  网络首发：2023-11-24，
  
  纸质出版：2024-01-12
- 稿件说明：
移动端阅览
葛文逸,刘巍,樊小农等.功能磁共振研究元分析方法介绍及其在针刺领域的应用探析[J].中国针灸,2024,44(01):25-33.

GE Wenyi,LIU Wei,FAN Xiaonong,et al.Introduction to the Meta-analysis method of functional magnetic resonance imaging research and the exploration of its application in the field of acupuncture[J].Chinese Acupuncture & Moxibustion,2024,44(01):25-33.
葛文逸,刘巍,樊小农等.功能磁共振研究元分析方法介绍及其在针刺领域的应用探析[J].中国针灸,2024,44(01):25-33. DOI： 10.13703/j.0255-2930.20230627-k0003.

GE Wenyi,LIU Wei,FAN Xiaonong,et al.Introduction to the Meta-analysis method of functional magnetic resonance imaging research and the exploration of its application in the field of acupuncture[J].Chinese Acupuncture & Moxibustion,2024,44(01):25-33. DOI： 10.13703/j.0255-2930.20230627-k0003.

摘要

近年来针刺领域功能磁共振成像（fMRI）研究数量不断增加，但由于腧穴选择、针刺手法以及样本量等差异，致使研究间结果分散、针刺共性规律不明的问题越发凸显。笔者以针刺治疗中风后运动障碍（PSMD）相关fMRI研究为例，引出并介绍了整合相关研究结果、提取共性规律的fMRI元分析技术：基于图像的元分析（IBMA）和基于坐标的元分析（CBMA）。鉴于CBMA的可实施性更高，故重点说明了3种可用的CBMA方法，即激活似然估计（ALE）、核密度分析（KDA）和基于种子的

映射（SDM）；并以开展CBMA的注意事项、操作流程为切入点，对研究的fMRI类型、任务设计、分析方法以及开展fMRI元分析的整体思维考量过程进行了系统梳理，整理成图表，旨在帮助读者能够快速、方便、相对系统地对其中抽象复杂的理论和实战信息进行了解和理解，为其今后更深入地学习和应用起到抛砖引玉的作用。

Abstract

In recent years

the number of functional magnetic resonance imaging (fMRI) research in acupuncture grows increasingly. However

due to the differences in acupoint selection

acupuncture technique and sample size

the problems get more prominent in terms of the diverse results and the lack of common rules of acupuncture among researches. By taking the fMRI research for post-stroke motor dysfunction (PSMD) treated with acupuncture as the example

this paper introduces the fMRI Meta-analysis technology for integrating the relevant research results and extracting the common rules

namely image-based Meta-analysis (IBMA) and coordinate-based Meta-analysis (CBMA). Considering the higher feasibility of CBMA

three available CBMA methods are explained specially

including activation likelihood estimation (ALE)

kernel density analysis (KDA)

and seed-based

mapping (SDM). Focusing on the precautions and operation procedure of CBMA

the review is conducted systematically on the type of fMRI research

task design

analytical method

and the thinking

integrity of fMRI Meta-analysis

and the review findings are collated in charts. It aims to assist readers to understand the abstract and complex theories and practical information of this technology efficiently

conveniently and systematically

and hopes to provide the references for the future learning and the application.

关键词

Keywords

references

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