Objective

2

To observe the clinical efficacy and safety of fire dragon cupping in prevention and treatment of chemotherapy-induced nausea and vomiting (CINV) in breast cancer.

Methods

2

Sixty breast cancer patients receiving medium-high emetogenic chemotherapy regimen were randomly divided into an observation group (30 cases

3 cases dropped out) and a control group (30 cases

3 cases dropped out). In both groups

5 mg tropisetron hydrochloride was given intravenously on the day of chemotherapy and 1st to 3rd days after chemotherapy. In the observation group

fire dragon cupping on the abdomen was applied on 1st

3rd and 5th days after chemotherapy. The incidence of nausea

vomiting

loss of appetite

abdominal pain

abdominal distension

the severity of nausea

vomiting on 1st to 6th days after chemotherapy

and the duration of nausea

vomiting

loss of appetite were observed in the two groups. The self-rating anxiety scale (SAS) score

general comfort questionnaire scale (GCQ) score before and after treatment and remedy antiemetic medication were observed in the two groups

and the safety was evaluated.

Results

2

On 2nd to 6th days after chemotherapy

the number of patients with nausea

loss of appetite and abdominal distension and nausea scores in the observation group were lower than those in the control group (

P

<

0.05). On 1st to 3rd days after chemotherapy

the number of patients with vomiting and vomiting scores in the observation group were lower than those in the control group (

P

<

0.05). The duration of nausea

vomiting and loss of appetite in the observation group were shorter than those in the control group (

P

<

0.05). In the observation group

there was no significant difference in SAS and GCQ scores before and after treatment (

P

>

0.05). After treatment

the GCQ score in the control group was decreased compared with that before treatment (

P

<

0.05). After treatment

there was no significant difference in SAS and GCQ scores between the two groups (

P

>

0.05).

There

was no significant difference in the number of patients using remedy medication between the two groups (

P

>

0.05).

No adverse reaction occurred during treatment in both groups.

Conclusion

2

Fire dragon cupping can effectively reduce the incidence of nausea

vomiting

loss of appetite and the severity of nausea

vomiting related to chemotherapy in breast cancer

and improve patient comfort

and have good safety.