调经促孕针法对卵巢储备功能减退患者IVF-ET妊娠结局的影响：队列研究

白杨; 陈枝岚; 弓爱东; 李薇; 杨莉; 李佳珊; 房繄恭; 许焕芳

doi:10.13703/j.0255-2930.20230716-k0002

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调经促孕针法对卵巢储备功能减退患者IVF-ET妊娠结局的影响：队列研究

临床研究 | 更新时间：2024-06-14

- 调经促孕针法对卵巢储备功能减退患者IVF-ET妊娠结局的影响：队列研究
- Effect of Tiaojing Cuyun acupuncture therapy on pregnancy outcomes in women with diminished ovarian reserve undergoing IVF-ET: a cohort study
- 中国针灸 2024年44卷第6期页码：653-658
- 作者机构：
  
  1.武汉康健妇婴医院中医科，湖北　武汉　430051
  2.武汉康健妇婴医院生殖中心，湖北　武汉　430051
  3.中国中医科学院针灸研究所，北京　100700
- 作者简介：
  
  ☒许焕芳，副主任医师。E-mail：huanfang_xu@126.com
- 基金信息：
  
  中国中医科学院科技创新工程项目(CI2021A03504;CI2021A03502;CI2021B012)
- DOI：10.13703/j.0255-2930.20230716-k0002
  中图分类号：
- 收稿：2023-07-16，
  
  网络首发：2024-04-02，
  
  纸质出版：2024-06-12
- 稿件说明：
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白杨, 陈枝岚, 弓爱东, 等. 调经促孕针法对卵巢储备功能减退患者IVF-ET妊娠结局的影响：队列研究[J]. 中国针灸, 2024,44(6):653-658.

BAI Yang, CHEN Zhilan, GONG Aidong, et al. Effect of Tiaojing Cuyun acupuncture therapy on pregnancy outcomes in women with diminished ovarian reserve undergoing IVF-ET: a cohort study[J]. Chinese Acupuncture & Moxibustion, 2024, 44(6): 653-658. DOI: 10.13703/j.0255-2930.20230716-k0002.
白杨, 陈枝岚, 弓爱东, 等. 调经促孕针法对卵巢储备功能减退患者IVF-ET妊娠结局的影响：队列研究[J]. 中国针灸, 2024,44(6):653-658. DOI： 10.13703/j.0255-2930.20230716-k0002.

BAI Yang, CHEN Zhilan, GONG Aidong, et al. Effect of Tiaojing Cuyun acupuncture therapy on pregnancy outcomes in women with diminished ovarian reserve undergoing IVF-ET: a cohort study[J]. Chinese Acupuncture & Moxibustion, 2024, 44(6): 653-658. DOI: 10.13703/j.0255-2930.20230716-k0002. DOI：

摘要

目的：

评价调经促孕针法对卵巢储备功能减退（DOR）患者体外受精-胚胎移植（IVF-ET）妊娠结局的影响。

方法：

将80例DOR患者按照是否接受调经促孕针法治疗分为观察组（40例，脱落1例）和对照组（40例，脱落1例）。对照组予IVF-ET，观察组在IVF-ET前采用调经促孕针法治疗，取百会、神庭、本神、中脘、关元及双侧天枢、肾俞、次髎等两组穴位，交替使用，隔日1次，每周3次，共治疗12周。以临床妊娠率为主要结局指标，以促性腺激素（Gn）使用天数及总量、获卵数、第2次减数分裂中期（MⅡ）卵数、可移植胚胎数、优质胚胎数、周期取消率、人体绒膜促性腺激素（HCG）阳性率、胚胎种植率、活产率及血清基础性激素水平[卵泡刺激素（FSH）、雌二醇（E2）、FSH/黄体生成素（LH）]、窦卵泡计数（AFC）为次要结局指标。

结果：

观察组临床妊娠率[53.8%（21/39）

]

高于对照组[17.9%（7/39），

0.05

]

。观察组获卵数、MⅡ卵数、可移植胚胎数、优质胚胎数、HCG阳性率、胚胎种植率及活产率均高于对照组（

0.05），血清FSH水平、FSH/LH均低于对照组（

0.05）；两组Gn使用天数及总量、周期取消率和血清E2水平、AFC比较，差异无统计学意义（

0.05）。逻辑回归分析显示，与对照组比较，观察组患者临床妊娠率升高（

=5.33

95%

: 1.90~14.97，

=0.001）。

结论：

针刺可以改善DOR患者IVF-ET的妊娠结局。

Abstract

Objective

To assess the effect of

Tiaojing Cuyun

acupuncture therapy (acupuncture for regulating menstruation and promoting pregnancy) on pregnancy outcomes in patients with diminished ovarian reserve (DOR) undergoing in vitro fertilization-embryo transfer (IVF-ET).

Methods

Eighty women with DOR were divided into an observation group (40 cases

1 case dropped out) and a control group (40 cases

1 case dropped out) according to whether

Tiaojing Cuyun

acupuncture therapy was given or not. In the control group

IVF-ET was delivered. In the observation group

before IVF-ET

Tiaojing Cuyun

acupuncture therapy was given. Two groups of acupoints were used alternatively

including Baihui (GV 20)

Shenting (GV 24)

Benshen (GB 13)

Zho

ngwan (CV 12)

Guanyuan (CV 4)

and bilateral Tianshu (ST 25)

Shenshu (BL 23)

Ciliao (BL 32)

etc. Acupuncture was operated once every other day

three interventions a week

for 12 weeks. The primary outcome was clinical pregnancy rate (CPR). Secondary outcomes included the total days and amount of gonadotropin (Gn) used

the number of oocytes retrieved

the number of oocytes in metaphase of second meiosis (MⅡ)

the number of transferable embryos

the number of high-quality embryos

the cycle cancellation rate

the positive rate of human choriogonadotropin (HCG)

the embryo implantation rate

live birth rate (LBR)

the basal serum levels of sex hormones (follicular stimulating hormone [FSH

]

estradiol (E2)

FSH/luteinizing hormone [LH

]

) and antral follicle count (AFC).

Results

CPR in the observation group was higher than that in the control group (53.8% [21/39

]

. 17.9% [7/39

]

0.05). The results of the number of oocytes retrieved

the number of oocytes in MⅡ

the number of transferable embryos

the number of high-quality embryos

the positive rate of HCG

the embryo implantation rate

and LBR in the observation group were higher than those in the control group (

0.05). The serum level of FSH and FSH/LH in the observation group were lower thau those in the control group (

0.05). The differences were not significant statistically in the total days and amount of Gn used

the cycle cancellation rate

serum level of E2 and AFC between the two groups (

0.05). Logic regression analysis showed that CPR increased in the observation group when compared with that of the control group (

= 5.33

95%

: 1.90-14.97

= 0.001).

Conclusion

Acupuncture can improve the pregnancy outcomes of DOR women undergoing IVF-ET.

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