This paper discusses the mechanism of acupuncture for diabetes mellitus from the perspective of molecular biology

aiming to reveal the potential rules of restoring the balance in the body and fighting against diabetes mellitus (DM). By searching the basic research literature of acupuncture treatment for DM

it is found that the molecular biological mechanism of acupuncture treatment for DM is closely related to the regulation of insulin signaling pathway

the modulation of inflammatory response

the protection and regeneration of islet β-cells

fat metabolism and energy balance. It points out that there are few studies of acupuncture on the type 1 diabetes mellitus and the large-scale randomized controlled trials

as well as the studies on the upstream regulation mechanism

the specific cellular molecules and the interaction mechanism of various molecules. It needs to deepen the multi-level

multi-target and multi-dimensional exploration on the molecular biological mechanism of acupuncture for diabetes mellitus.