益髓养心灸防治女性围绝经期高血压前期的探索性研究

何瑷芯; 赵利华; 邹卓成; 黄瑜; 黄鼎坚

doi:10.13703/j.0255-2930.20240610-k0002

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益髓养心灸防治女性围绝经期高血压前期的探索性研究

临床研究 | 更新时间：2025-08-14

- 益髓养心灸防治女性围绝经期高血压前期的探索性研究
- Exploratory study of Yisui Yangxin moxibustion in prevention and treatment of prehypertension in perimenopausal women
- 中国针灸 2025年45卷第8期页码：1083-1091
- 作者机构：
  
  广西中医药大学研究生院，南宁　530001
  广西中医药大学第一附属医院仁爱分院针灸科，南宁　530000
  广西中医药大学第一附属医院针灸科
- 作者简介：
  
  ✉赵利华，教授。E-mail：zhaolh67@163.com
- 基金信息：
  
  国家自然科学基金资助项目(82160933);广西壮族自治区自然科学基金项目(2023GXNSFAA026094;2022GXNSFAA035577);广西中医药大学“桂派中医药传承创新团队”资助项目(2022V005);广西中医药适宜技术与开发推广项目(GZSY22-20)
- DOI：10.13703/j.0255-2930.20240610-k0002
  中图分类号：
- 收稿：2024-06-10，
  
  网络首发：2025-05-06，
  
  纸质出版：2025-08-12
- 稿件说明：
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何瑷芯, 赵利华, 邹卓成, 等. 益髓养心灸防治女性围绝经期高血压前期的探索性研究[J]. 中国针灸, 2025,45(8):1083-1091.

HE Aixin, ZHAO Lihua, ZOU Zhuocheng, et al. Exploratory study of Yisui Yangxin moxibustion in prevention and treatment of prehypertension in perimenopausal women[J]. Chinese Acupuncture & Moxibustion, 2025, 45(8): 1083-1091. DOI: 10.13703/j.0255-2930.20240610-k0002.
何瑷芯, 赵利华, 邹卓成, 等. 益髓养心灸防治女性围绝经期高血压前期的探索性研究[J]. 中国针灸, 2025,45(8):1083-1091. DOI： 10.13703/j.0255-2930.20240610-k0002.

HE Aixin, ZHAO Lihua, ZOU Zhuocheng, et al. Exploratory study of Yisui Yangxin moxibustion in prevention and treatment of prehypertension in perimenopausal women[J]. Chinese Acupuncture & Moxibustion, 2025, 45(8): 1083-1091. DOI: 10.13703/j.0255-2930.20240610-k0002. DOI：

摘要

目的：

基于序贯试验观察益髓养心灸对女性围绝经期高血压前期患者的血压、围绝经期症状、心血管功能以及心率变异性（HRV）的影响。

方法：

选取符合纳入标准的女性围绝经期高血压前期患者，根据开放型双向质反应序贯试验的要求，不预先设置样本量，采用配对设计分组，随机分为艾灸组和健康教育组，两组逐对进行治疗，每对治疗结束立即分析，并绘制序贯试验线。健康教育组根据《中国高血压防治指南2018年修订版》对患者进行高血压前期健康教育；艾灸组在高血压前期健康教育的基础上，于百会、关元及双侧内关、足三里穴行非化脓灸，隔日1次，每周3次，持续治疗4周。于治疗前，治疗2、4周后及治疗后1个月（随访），测量两组患者血压；于治疗前、治疗4周后，观察两组患者改良Kupperman量表评分、匹兹堡睡眠质量指数（PSQI）评分、心血管功能指标[每搏输出量（SV）、每分心输出量（CO）、心搏指数（SI）、心脏指数（CI）、左心室有效泵力（VPE）、左心能量有效利用率（EWK）、动脉顺应性（AC）、左心室喷血阻抗（VER）、血液黏度（N）、微循环半更新率（MHR）]、心率变异性（HRV）指标[低频功率（LF）、高频功率（HF）、LF/HF、时域指标NN间期的标准差（SDNN）、相邻NN间期差的均方根（RMSSD）]。

结果：

根据序贯试验线，当试验进行至第17对时，试验线触及上边界线

，得出艾灸组优于健康教育组的结论，立即停止试验。治疗2、4周后及随访时，艾灸组患者收缩压（SBP）、舒张压（DBP）低于治疗前（

0.05），艾灸组各时点SBP及治疗2、4周后DBP低于健康教育组（

0.05）。艾灸组患者治疗后改良Kupperman量表评分较治疗前降低（

0.05）；艾灸组患者治疗后改良Kupperman量表评分、PSQI评分均低于健康教育组（

0.05）。治疗后，艾灸组患者SV、CO、SI、CI、EWK较治疗前升高（

0.05），VER、N较治疗前降低（

0.05）；艾灸组患者SV、CO、SI、CI、EWK高于健康教育组（

0.05），VER、N低于健康教育组（

0.05）。艾灸组患者治疗后LF、HF、SDNN、RMSSD较治疗前升高（

0.05），LF/HF较治疗前降低（

0.05），健康教育组患者治疗后LF、HF、SDNN、RMSSD较治疗前降低（

0.05）；治疗后，艾灸组患者LF、HF、SDNN、RMSSD高于健康教育组（

0.05），LF/HF低于健康教育组（

0.05）。艾灸组总有效率为94.1%（16/17），高于健康教育组的41.2%（7/17，

0.05）。

结论：

艾灸可降低女性围绝经期高血压前期患者SBP、DBP水平，缓解患者围绝经期症状，改善心脏功能，调节心脏自主神经总体平衡性。

Abstract

Objective

To observe the effects of

Yisui Yangxin

moxibustion (moxibustion for benefiting the marrow and nourishing the heart) in sequential trial on blood pressure (BP)

perimenopausal symptoms

cardiovascular function and heart rate variability (HRV) in prehypertension in perimenopausal women.

Methods

The eligible female patients of prehypertension of perimenopausal period were collected according to the inclusion criteria. Based on the requirements of open two-way qualitative response sequential trial

the sample size was not set in advance

and the matched pair design was used for random division into a moxibustion group and a health education group. The patients of the two groups were treated in pairs

and the analysis was immediately performed after the end of treatment for each pair

and the sequential trial analysis (STA) was diagrammed. The health education group provided the health education for prehypertension to the patients according to

2018 Revised Chinese Hypertension Prevention and Treatment Guidelines

. In the moxibustion group

beside the health education for prehypertension

the non-suppurative moxibustion was delivered at Baihui (GV20)

Guanyuan (CV4) and bilateral Neiguan (PC6) and Zusanli (ST36)

once every two days

3 treatments per week and for 4 consecutive weeks. Before treatment

in 2 and 4 weeks of treatment

as well as in 1-month follow-up

after treatment

BP was measured in each group

separately. Before treatment and in 4 weeks of treatment

the observation was performed in the score of the modified Kupperman scale

and Pittsburgh sleep quality index (PSQI) score

the indexes of cardiovascular function (stroke volume [SV

]

cardiac output per minute [CO

]

stroke index [SI

]

cardiac index [CI

]

left ventricular effective pumping force [VPE

]

left ventricular energy efficiency [EWK

]

arterial compliance [AC

]

left ventricular ejection resistance [VER

]

blood viscosity (N)

and microcirculation half update rate [MHR

]

)

and heart rate variability (HRV) indexes (low frequency [LF

]

high frequency [HF

]

LF/HF

standard deviation of NN interval [SDNN

]

root mean square of successive differences in adjacent NN intervals [RMSSD

]

Results

Based on sequential test line

when the trial was performed to the 17th pair

and the test line touched the upper limit

meaning the results of the moxibustion group was superior to the health education group

thus

the trial stopped immediately. In 2 and 4 weeks of treatment and in follow-up

the systolic blood pressure (SBP) and diastolic blood pressure (DBP) were lower when compared with those before treatment in the moxibustion group (

0.05); SBP at each time point and DBP in 2 and 4 weeks of treatment in the moxibustion group were lower than those of the health education group (

0.05). After treatment

the score of the modified Kupperman scale was reduced when compared with that before treatment in the moxibustion group (

0.05). The score of the modified Kupperman scale and PSQI in the moxibustion group were lower than those of the health education group after treatment (

0.05). After treatment

CI and EWK were increased in comparison with the indexes before treatment in the moxibustion group (

0.05)

and VER and N were dropped (

0.05). After treatment

CI and EWK in the moxibustion group were higher than those of the health education group (

0.05)

and VER and N were lower (

0.05). After treatment

in the moxibustion group

SDNN and RMSSD were increased in comparison with those before treatment (

0.05)

and LF/HF was declined (

0.05). In the health education group

after treatment

SDNN and RMSSD decreased when compared with those before treatment (

0.05). After treatment

SDNN and RMSSD in the moxibustion group were higher than those of the health education group (

0.05)

and LF/HF was lower (

0.05). The total effective rate was 94.1% (16/17) in the moxibustion group

higher than that (41.2%

7/17) in the health education group (

0.05).

Conclusion

Moxibustion can reduce SBP and DBP in prehypertension of perimenopausal women

alleviate perimenopausal symptoms

improve cardiac function and adjust the overall balance of cardiac autonomic nerves.

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