调枢安神法针刺对慢性失眠症患者睡眠质量及血清神经递质含量的影响

刘恋; 鄢天涯; 陈壮志; 康贞; 李梦瑶; 高琼珏; 覃佐爱; 文业成; 刘未艾; 付中应

doi:10.13703/j.0255-2930.20240613-k0006

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调枢安神法针刺对慢性失眠症患者睡眠质量及血清神经递质含量的影响

临床研究 | 更新时间：2025-02-14

- 调枢安神法针刺对慢性失眠症患者睡眠质量及血清神经递质含量的影响
- Effects of Tiaoshu Anshen acupuncture on sleep quality and serum neurotransmitter levels in patients with chronic insomnia
- 中国针灸 2025年45卷第2期页码：151-155
- 作者机构：
  
  湖南中医药大学第二附属医院针灸推拿康复科，长沙　410005
- 作者简介：
  
  ✉付中应，副主任医师。E-mail：349218201@qq.com
- 基金信息：
  
  湖南省卫生健康委科研项目(D202319017502);湖南省自然科学基金项目(2023JJ40495);湖南中医药大学校级课题项目(Z2023YYJJ11);国家中医药管理局全国名老中医药专家传承工作室建设项目(国中医药人教函〔2022〕75号)
- DOI：10.13703/j.0255-2930.20240613-k0006
  中图分类号：
- 收稿：2024-06-13，
  
  网络首发：2024-11-28，
  
  纸质出版：2025-02-12
- 稿件说明：
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刘恋, 鄢天涯, 陈壮志, 等. 调枢安神法针刺对慢性失眠症患者睡眠质量及血清神经递质含量的影响[J]. 中国针灸, 2025,45(2):151-155.

LIU Lian, YAN Tianya, CHEN Zhuangzhi, et al. Effects of Tiaoshu Anshen acupuncture on sleep quality and serum neurotransmitter levels in patients with chronic insomnia[J]. Chinese Acupuncture & Moxibustion, 2025, 45(2): 151-155. DOI: 10.13703/j.0255-2930.20240613-k0006.
刘恋, 鄢天涯, 陈壮志, 等. 调枢安神法针刺对慢性失眠症患者睡眠质量及血清神经递质含量的影响[J]. 中国针灸, 2025,45(2):151-155. DOI： 10.13703/j.0255-2930.20240613-k0006.

LIU Lian, YAN Tianya, CHEN Zhuangzhi, et al. Effects of Tiaoshu Anshen acupuncture on sleep quality and serum neurotransmitter levels in patients with chronic insomnia[J]. Chinese Acupuncture & Moxibustion, 2025, 45(2): 151-155. DOI: 10.13703/j.0255-2930.20240613-k0006. DOI：

摘要

目的：

观察调枢安神法针刺对慢性失眠症患者睡眠质量及血清神经递质5-羟色胺（5-HT）、多巴胺（DA）含量的影响。

方法：

将58例慢性失眠症患者随机分为针刺组（29例）和西药组（29例）。针刺组采用调枢安神法针刺治疗，穴取百会及双侧神门、三阴交、本神，每日1次，连续治疗6 d后休息1 d；西药组睡前口服艾司唑仑片治疗，每次1 mg，两组均治疗4周。分别于治疗前后运用匹兹堡睡眠质量指数（PSQI）评分和多导睡眠监测（PSG）评估患者睡眠质量，采用ELISA法检测患者血清5-HT、DA含量。

结果：

治疗后，两组患者PSQI各项评分及总分均降低(

0.05)，针刺组患者PSQI睡眠质量、入睡时间、睡眠时间、睡眠效率、睡眠障碍评分及总分低于西药组(

0.05)。治疗后，两组患者总睡眠时间（TST）延长（

0.05），睡眠潜伏期（SL）和入睡后清醒时间（WASO）缩短（

0.05），睡眠效率（SE%）、非快速眼动睡眠第3期百分比（N3%）、快速眼动睡眠百分比（REM%）、血清5-HT含量较治疗前升高（

0.05），非快速眼动睡眠第1期百分比（N1%）、非快速眼动睡眠第2期百分比（N2%）、血清DA含量较治疗前降低（

0.05）；针刺组患者TST长于西药组（

0.05），SL和WASO短于西药组（

0.05），SE%、N3%、REM%、血清5-HT含量高于西药组（

0.05），N1%、N2%、血清DA含量低于西药组（

0.05）。

结论：

调枢安神法针刺可能通过调节血清神经递质5-HT、DA含量，进而改善慢性失眠症患者睡眠质量。

Abstract

Objective

To observe the effects of

Tiaoshu Anshen

(regulating the hinge and calming the mind) acupuncture on sleep quality and serum levels of 5-hydroxytryptamine (5-HT) and dopamine (DA) in patients with chronic insomnia.

Methods

A total of 58 patients with chronic insomnia were randomly divided into an acupuncture group and a medication group

29 cases in each group.

Tiaoshu Anshen

acupuncture was applied at Baihui (GV20) and bilateral Shenmen (HT7)

Sanyinjiao (SP6)

Benshen (GB13) in the acupuncture group

once a day

1-day interval was taken after 6 consecutive days of treatment. Estazolam tablet was given orally before bed in the medication group

1 mg each time. The 4-week treatment was required in both groups. Before and after treatment

the sleep quality was assessed by Pittsburgh sleep quality index (PSQI) and polysomnography (PSG)

the serum levels of 5-HT and DA were detected by ELISA.

Results

After treatment

the item scores and total

scores of PSQI were decreased compared with those before treatment in the two groups (

0.05); in the acupuncture group

the scores of sleep quality

sleep latency

sleep time

sleep efficiency

sleep disorders and total score of PSQI were lower than those in the medication group (

0.05). After treatment

the total sleep time (TST) was prolonged (

0.05)

the sleep latency (SL) and wake after sleep onset (WASO) were shortened (

0.05)

the sleep efficiency (SE%)

percentage of non-rapid eye movement stage 3 (N3%)

percentage of rapid eye movement stage (REM%) and serum levels of 5-HT were increased (

0.05) compared with those before treatment; the percentage of non-rapid eye movement stage 1 (N1%)

percentage of non-rapid eye movement stage 2 (N2%) and serum levels of DA were decreased (

0.05) compared with those before treatment in the two groups. After treatment

in the acupuncture group

TST was longer

while SL and WASO were shorter than those in the medication group (

0.05)

SE%

N3%

REM% and serum level of 5-HT were higher

while N1%

N2% and serum level of DA were lower than those in the medication group (

0.05).

Conclusion

Tiaoshu Anshen

acupuncture may improve the sleep quality by regulating the serum neurotransmitter levels i.e. 5-HT and DA in patients with chronic insomnia.

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